公开(公告)号：CA2869847A1

公开(公告)日：2013-10-24

申请号：CA2869847

申请日：2012-04-20

Applicant: VERTEX PHARMA

Inventor： LUISI BRIAN ,  AREKAR SNEHA GHANSHYAM ,  COSTACHE ADRIANA ,  DINEHART KIRK RAYMOND ,  JOHNSTON STEVEN C ,  NEUBERT-LANGILLE BOBBIANNA J

IPC: C07D215/56 ,  A61K31/47 ,  A61P25/00

Abstract: The present invention relates to crystalline solvate forms of N-[2,4-bis(1,1- dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods for their preparation. The present invention further relates to pharmaceutical compositions comprising the crystalline solvate forms, as well as methods of treatment therewith.

公开(公告)号：AU2018351533A8

公开(公告)日：2020-05-07

申请号：AU2018351533

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI ,  CHEN WEICHAO GEORGE ,  HASELTINE ERIC L ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：AU2018351533B2

公开(公告)日：2023-02-02

申请号：AU2018351533

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI ,  CHEN WEICHAO GEORGE ,  HASELTINE ERIC L ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：AU2012377446A1

公开(公告)日：2014-10-23

申请号：AU2012377446

申请日：2012-04-20

Applicant: VERTEX PHARMA

Inventor： LUISI BRIAN ,  AREKAR SNEHA GHANSHYAM ,  COSTACHE ADRIANA ,  DINEHART KIRK RAYMOND ,  JOHNSTON STEVEN C ,  NEUBERT-LANGILLE BOBBIANNA J

IPC: C07D215/56 ,  A61K31/47 ,  A61P25/00

Abstract: The present invention relates to crystalline solvate forms of N-[2,4-bis(1,1- dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods for their preparation. The present invention further relates to pharmaceutical compositions comprising the crystalline solvate forms, as well as methods of treatment therewith.

公开(公告)号：MA50400A

公开(公告)日：2020-08-26

申请号：MA50400

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： CHEN WELCHAO GEORGE ,  DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  HASELTINE ERIC L ,  MCCARTY KATIE ,  METZLER CATHERINE ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID ,  ZHANG BEILI

IPC: A61K31/4439 ,  A61P11/00 ,  C07D401/14

公开(公告)号：AU2018351533A1

公开(公告)日：2020-04-30

申请号：AU2018351533

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：CA3078893A1

公开(公告)日：2019-04-25

申请号：CA3078893

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI ,  CHEN WEICHAO GEORGE ,  HASELTINE ERIC L ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.