公开(公告)号：MX2025000710A

公开(公告)日：2025-03-07

申请号：MX2025000710

申请日：2025-01-17

Applicant: VERTEX PHARMA

Inventor： DINEHART KIRK ,  TIPS LAUREN BAILEY ,  METZLER CATHERINE ,  MCCARTY KATIE

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/20 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61P11/00

Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen N-(1,3-dimetilpirazol-4-il)sulfonil-6-[3-(3,3,3-trifluoro-2,2-dimetil-propoxi)pirazol-1-il]-2-[(4S)-2,2,4-trimetilpirrolidin-1-il]piridin-3-carboxamida, una dispersión sólida de (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1H-indol-5-il)ciclopropanocarboxamida, y una dispersión sólida de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida que incluyen formulaciones de las dispersiones sólidas en polvos, gránulos y minitabletas, métodos para fabricar y procesar los polvos, gránulos y minitabletas, y métodos para tratar la fibrosis quística mediante el empleo de las composiciones farmacéuticas.

公开(公告)号：AU2018351533B2

公开(公告)日：2023-02-02

申请号：AU2018351533

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI ,  CHEN WEICHAO GEORGE ,  HASELTINE ERIC L ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：CO2025001274A2

公开(公告)日：2025-02-13

申请号：CO2025001274

申请日：2025-02-04

Applicant: VERTEX PHARMA

Inventor： DINEHART KIRK ,  TIPS LAUREN BAILEY ,  METZLER CATHERINE ,  MCCARTY KATIE

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/20 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61P11/00

Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen N-(1,3-dimetilpirazol-4-il)sulfonil-6-[3-(3,3,3-trifluoro-2,2-dimetil-propoxi)pirazol-1-il]-2-[(4S)-2,2,4-trimetilpirrolidin-1-il]piridin-3-carboxamida, una dispersión sólida de (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1H-indol-5-il)ciclopropanocarboxamida, y una dispersión sólida de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida que incluyen formulaciones de las dispersiones sólidas en polvos, gránulos y minitabletas, métodos para fabricar y procesar los polvos, gránulos y minitabletas, y métodos para tratar la fibrosis quística mediante el empleo de las composiciones farmacéuticas.

公开(公告)号：AU2018351533A8

公开(公告)日：2020-05-07

申请号：AU2018351533

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI ,  CHEN WEICHAO GEORGE ,  HASELTINE ERIC L ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：SG10201913575VA

公开(公告)日：2020-02-27

申请号：SG10201913575V

申请日：2015-04-14

Applicant: VERTEX PHARMA

Inventor： PHENIX BRIAN ,  BAGNOL LAURENT ,  BRODEUR GEOFFREY ,  CHANDRAN SACHIN ,  DOKOU ELENI ,  FERRIS LORI ,  KNEZIC DRAGUTIN ,  MCCARTY KATIE ,  MEDEK ALES ,  WAGGENER SARA

Abstract: PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MEDIATED DISEASES The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed. Fig: None

公开(公告)号：AU2023320558A1

公开(公告)日：2025-01-23

申请号：AU2023320558

申请日：2023-08-04

Applicant: VERTEX PHARMA

Inventor： DINEHART KIRK ,  TIPS LAUREN ,  METZLER CATHERINE ,  MCCARTY KATIE

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/20 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61P11/00

Abstract: The present invention relates to pharmaceutical compositions containing N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3, 3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, a solid dispersion of (

公开(公告)号：MA50400A

公开(公告)日：2020-08-26

申请号：MA50400

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： CHEN WELCHAO GEORGE ,  DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  HASELTINE ERIC L ,  MCCARTY KATIE ,  METZLER CATHERINE ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID ,  ZHANG BEILI

IPC: A61K31/4439 ,  A61P11/00 ,  C07D401/14

公开(公告)号：AU2018351533A1

公开(公告)日：2020-04-30

申请号：AU2018351533

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：CA3078893A1

公开(公告)日：2019-04-25

申请号：CA3078893

申请日：2018-10-19

Applicant: VERTEX PHARMA

Inventor： DHAMANKAR VARSHA ,  DINEHART KIRK RAYMOND ,  DOKOU ELENI ,  FERRIS LORI ANN ,  GOPINATHAN NISHANTH ,  MCCARTY KATIE ,  METZLER CATHERINE ,  ZHANG BEILI ,  CHEN WEICHAO GEORGE ,  HASELTINE ERIC L ,  MOSKOWITZ SAMUEL ,  ROBERTSON SARAH ,  WALTZ DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/00

Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.