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公开(公告)号：MX2025000710A
公开(公告)日：2025-03-07
申请号：MX2025000710
申请日：2025-01-17
Applicant: VERTEX PHARMA
Inventor： DINEHART KIRK , TIPS LAUREN BAILEY , METZLER CATHERINE , MCCARTY KATIE
IPC: A61K9/16 , A61K9/14 , A61K9/20 , A61K31/404 , A61K31/4439 , A61K31/47 , A61P11/00
Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen N-(1,3-dimetilpirazol-4-il)sulfonil-6-[3-(3,3,3-trifluoro-2,2-dimetil-propoxi)pirazol-1-il]-2-[(4S)-2,2,4-trimetilpirrolidin-1-il]piridin-3-carboxamida, una dispersión sólida de (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1H-indol-5-il)ciclopropanocarboxamida, y una dispersión sólida de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida que incluyen formulaciones de las dispersiones sólidas en polvos, gránulos y minitabletas, métodos para fabricar y procesar los polvos, gránulos y minitabletas, y métodos para tratar la fibrosis quística mediante el empleo de las composiciones farmacéuticas.
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公开(公告)号：AU2018351533B2
公开(公告)日：2023-02-02
申请号：AU2018351533
申请日：2018-10-19
Applicant: VERTEX PHARMA
Inventor： DHAMANKAR VARSHA , DINEHART KIRK RAYMOND , DOKOU ELENI , FERRIS LORI ANN , GOPINATHAN NISHANTH , MCCARTY KATIE , METZLER CATHERINE , ZHANG BEILI , CHEN WEICHAO GEORGE , HASELTINE ERIC L , MOSKOWITZ SAMUEL , ROBERTSON SARAH , WALTZ DAVID
IPC: C07D401/14 , A61K31/4439 , A61P11/00
Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：AR113783A1
公开(公告)日：2020-06-10
申请号：ARP180103067
申请日：2018-10-19
Applicant: VERTEX PHARMA
Inventor： ZHANG BEILI , METZLER CATHERINE , MCARTY KATIE , GOPINATHAN NISHANTH , FERRIS LORI A , DOKOU ELENI , DINEHART KIRK R , DHAMANKAR VARSHA
IPC: C07D401/14 , A61K31/4439 , A61P11/00
Abstract: Una sal de potasio del compuesto de fórmula (1). También se describen composiciones farmacéuticas que comprenden la misma, y métodos para preparar formas cristalinas.
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公开(公告)号：CO2025001274A2
公开(公告)日：2025-02-13
申请号：CO2025001274
申请日：2025-02-04
Applicant: VERTEX PHARMA
Inventor： DINEHART KIRK , TIPS LAUREN BAILEY , METZLER CATHERINE , MCCARTY KATIE
IPC: A61K9/16 , A61K9/14 , A61K9/20 , A61K31/404 , A61K31/4439 , A61K31/47 , A61P11/00
Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen N-(1,3-dimetilpirazol-4-il)sulfonil-6-[3-(3,3,3-trifluoro-2,2-dimetil-propoxi)pirazol-1-il]-2-[(4S)-2,2,4-trimetilpirrolidin-1-il]piridin-3-carboxamida, una dispersión sólida de (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1H-indol-5-il)ciclopropanocarboxamida, y una dispersión sólida de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida que incluyen formulaciones de las dispersiones sólidas en polvos, gránulos y minitabletas, métodos para fabricar y procesar los polvos, gránulos y minitabletas, y métodos para tratar la fibrosis quística mediante el empleo de las composiciones farmacéuticas.
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Patent Agency Ranking
公开(公告)号：AU2018351533A8
公开(公告)日：2020-05-07
申请号：AU2018351533
申请日：2018-10-19
Applicant: VERTEX PHARMA
Inventor： DHAMANKAR VARSHA , DINEHART KIRK RAYMOND , DOKOU ELENI , FERRIS LORI ANN , GOPINATHAN NISHANTH , MCCARTY KATIE , METZLER CATHERINE , ZHANG BEILI , CHEN WEICHAO GEORGE , HASELTINE ERIC L , MOSKOWITZ SAMUEL , ROBERTSON SARAH , WALTZ DAVID
IPC: C07D401/14 , A61K31/4439 , A61P11/00
Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：AU2023320558A1
公开(公告)日：2025-01-23
申请号：AU2023320558
申请日：2023-08-04
Applicant: VERTEX PHARMA
Inventor： DINEHART KIRK , TIPS LAUREN , METZLER CATHERINE , MCCARTY KATIE
IPC: A61K9/16 , A61K9/14 , A61K9/20 , A61K31/404 , A61K31/4439 , A61K31/47 , A61P11/00
Abstract: The present invention relates to pharmaceutical compositions containing N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3, 3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, a solid dispersion of (
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公开(公告)号：MA50400A
公开(公告)日：2020-08-26
申请号：MA50400
申请日：2018-10-19
Applicant: VERTEX PHARMA
Inventor： CHEN WELCHAO GEORGE , DHAMANKAR VARSHA , DINEHART KIRK RAYMOND , DOKOU ELENI , FERRIS LORI ANN , GOPINATHAN NISHANTH , HASELTINE ERIC L , MCCARTY KATIE , METZLER CATHERINE , MOSKOWITZ SAMUEL , ROBERTSON SARAH , WALTZ DAVID , ZHANG BEILI
IPC: A61K31/4439 , A61P11/00 , C07D401/14
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公开(公告)号：AU2018351533A1
公开(公告)日：2020-04-30
申请号：AU2018351533
申请日：2018-10-19
Applicant: VERTEX PHARMA
Inventor： DHAMANKAR VARSHA , DINEHART KIRK RAYMOND , DOKOU ELENI , FERRIS LORI ANN , GOPINATHAN NISHANTH , MCCARTY KATIE , METZLER CATHERINE , ZHANG BEILI
IPC: C07D401/14 , A61K31/4439 , A61P11/00
Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：CA3078893A1
公开(公告)日：2019-04-25
申请号：CA3078893
申请日：2018-10-19
Applicant: VERTEX PHARMA
Inventor： DHAMANKAR VARSHA , DINEHART KIRK RAYMOND , DOKOU ELENI , FERRIS LORI ANN , GOPINATHAN NISHANTH , MCCARTY KATIE , METZLER CATHERINE , ZHANG BEILI , CHEN WEICHAO GEORGE , HASELTINE ERIC L , MOSKOWITZ SAMUEL , ROBERTSON SARAH , WALTZ DAVID
IPC: C07D401/14 , A61K31/4439 , A61P11/00
Abstract: Crystalline Forms of Compound (I): (Formula (I)) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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