公开(公告)号：AP813A

公开(公告)日：2000-02-28

申请号：AP9700973

申请日：1997-04-23

Applicant: VERTEX PHARMA

Inventor： ARMISTEAD DAVID ,  BADIA MICHAEL C ,  BEMIS GUY ,  BETHIEL RANDY S ,  FRANK CATHRINE A ,  NOVAK PERRY M ,  RONKIN STEVEN M ,  SAUNDERS JEFFREY

IPC: A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12 ,  C07C275/00 ,  A61

Abstract: A class of compounds which are IMPDH inhibitors, and pharmaceutical compositions comprising these compounds, of the formula: A is selected from (Ci-C6) alkyl, or (C2-C6)- alkenyl or alkynyl; B is a monocyclic or bicyclic ring system, D is selected from C(O), C(S), or S(0)2.