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公开(公告)号：WO2014143242A8
公开(公告)日：2015-03-05
申请号：PCT/US2013073477
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRIS , DURRANT STEVEN , FRAYSSE DAMIEN , JIMENEZ JUAN-MIGUEL , KAY DAVE , KNEGTEL RONALD , O'DONNELL MICHAEL , PIERARD FRANCOISE , PINDER JOANNE , STORCK PIERRE-HENRI , TWIN HEATHER
IPC: C07D487/04 , A61K31/437 , A61P35/00
CPC classification number: C07D487/04 , A61K31/437 , C07D491/107 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I); or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.
Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明化合物具有式（I）; 或其药学上可接受的盐，其中变量R1，R2，R3和R4如本文所定义。
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公开(公告)号：WO2008115973A3
公开(公告)日：2008-12-04
申请号：PCT/US2008057465
申请日：2008-03-19
Applicant: VERTEX PHARMA , BINCH HAYLEY , YOUNG STEPHEN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , GOLEC JULIAN , STUDLEY JOHN , ROBINSON DANIEL , O'DONNELL MICHAEL , BOYALL DEAN , PINDER JOANNE , EVERITT SIMON
Inventor： BINCH HAYLEY , YOUNG STEPHEN , DAVIS CHRISTOPHER , MORTIMORE MICHAEL , GOLEC JULIAN , STUDLEY JOHN , ROBINSON DANIEL , O'DONNELL MICHAEL , BOYALL DEAN , PINDER JOANNE , EVERITT SIMON
IPC: C07D403/14 , A61K31/33 , A61K35/00 , C07D413/14 , C07D417/14 , C07D471/04
CPC classification number: C07D471/04 , C07D403/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
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公开(公告)号：WO2007056164A3
公开(公告)日：2007-12-13
申请号：PCT/US2006042994
申请日：2006-11-03
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物以及使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2007056221A2
公开(公告)日：2007-05-18
申请号：PCT/US2006043096
申请日：2006-11-03
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
IPC: A61K31/513
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2005085236A3
公开(公告)日：2005-10-20
申请号：PCT/US2005006540
申请日：2005-02-28
Applicant: VERTEX PHARMA , CHARRIER JEAN-DAMIEN , DURRANT STEVEN , MORTIMORE MICHAEL , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , RAMAYA SHARN , STUDLEY JOHN R , TRUDEAU MARTIN , LOOKER ADAM
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , MORTIMORE MICHAEL , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , RAMAYA SHARN , STUDLEY JOHN R , TRUDEAU MARTIN , LOOKER ADAM
IPC: A61K38/04 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04 , A61K31/401 , A61K31/4025 , A61K31/403 , A61K31/443 , A61P37/00
CPC classification number: C07D405/12 , A61K38/06 , C07D207/16 , C07D209/52 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/12 , C07K5/0202
Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
Abstract translation: 本发明提供式（I）的化合物：其中变量如本文所定义。 本发明还提供制备式（I）化合物及其中间体，包含那些化合物的药物组合物的方法，以及使用该化合物和组合物的方法。
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Patent Agency Ranking
公开(公告)号：WO2004087699A3
公开(公告)日：2004-12-09
申请号：PCT/US2004009166
申请日：2004-03-25
Applicant: VERTEX PHARMA , BRENCHLEY GUY , FARMER LUC J , HARRINGTON EDMUND MARTIN , KNEGTEL RONALD , O'DONNELL MICHAEL , SALITURO FRANCESCO G , STUDLEY JOHN R , WANG JIAN
Inventor： BRENCHLEY GUY , FARMER LUC J , HARRINGTON EDMUND MARTIN , KNEGTEL RONALD , O'DONNELL MICHAEL , SALITURO FRANCESCO G , STUDLEY JOHN R , WANG JIAN
IPC: A61K31/506 , A61P29/00 , A61P35/00 , A61P37/00 , C07D417/00 , C07D417/04 , C07D417/14
CPC classification number: C07D417/14 , C07D417/04
Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. These compounds have the general formula I: Or a pharmaceutically acceptable salt thereof, wherein R , R , R , R , and Ar are as defined in the present claims.
Abstract translation: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 这些化合物具有通式I：或其药学上可接受的盐，其中R 1，R 2，R 3，R 4和Ar 1如本权利要求中所定义。
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公开(公告)号：EP1954277A4
公开(公告)日：2011-11-09
申请号：EP06836938
申请日：2006-11-03
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
IPC: A61K31/505 , C07D239/02 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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公开(公告)号：EP1948193A4
公开(公告)日：2011-11-09
申请号：EP06836890
申请日：2006-11-03
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
IPC: C07D401/14 , A61K31/505 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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公开(公告)号：SI3354650T1
公开(公告)日：2022-06-30
申请号：SI200932162
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： KAY DAVID , CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/00 , A61K31/00 , A61P35/00 , C07D401/00 , C07D403/00 , C07D409/00 , C07D417/00 , C07D471/00
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公开(公告)号：AU2018201363C1
公开(公告)日：2020-06-18
申请号：AU2018201363
申请日：2018-02-26
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , YOUNG STEPHEN , REAPER PHILIP MICHAEL , VIRANI ANISA NIZARALI
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; me thods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermedia tes fo r the prepara tion of the com pound s of this inve ntion; an d method s of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (I):whereir the variables are as defined herein
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