公开(公告)号：WO2007056221A2

公开(公告)日：2007-05-18

申请号：PCT/US2006043096

申请日：2006-11-03

Applicant: VERTEX PHARMA ,  BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: A61K31/513

CPC classification number: C07D403/12 ,  C07D239/38 ,  C07D401/14 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：EP1954277A4

公开(公告)日：2011-11-09

申请号：EP06836938

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: A61K31/505 ,  C07D239/02 ,  C07D401/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D403/12 ,  C07D239/38 ,  C07D401/14 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

公开(公告)号：AU2013201630A1

公开(公告)日：2013-04-18

申请号：AU2013201630

申请日：2013-03-19

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: C07D239/02 ,  A61K31/505

Abstract: Abstract Disclosed are aminopyrimidine compounds useful as inhibitors of protein kinases. Also disclosed are pharmaceutically acceptable compositions comprising the compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions and disorders. Processes for preparing the compounds are also disclosed.

公开(公告)号：AU2013201630B2

公开(公告)日：2016-12-01

申请号：AU2013201630

申请日：2013-03-19

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: C07D239/02 ,  A61K31/505

Abstract: Abstract Disclosed are aminopyrimidine compounds useful as inhibitors of protein kinases. Also disclosed are pharmaceutically acceptable compositions comprising the compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions and disorders. Processes for preparing the compounds are also disclosed.

公开(公告)号：AU2016203378A1

公开(公告)日：2016-06-23

申请号：AU2016203378

申请日：2016-05-24

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: C07D239/02 ,  A61K31/505

Abstract: Compounds and pharmaceutically acceptable compositions thereof that are useful as inhibitors of protein kinases. These compounds are represented by formula I: RY N Q,,RI or a pharmaceutically acceptable salt thereof, wherein R', RX, R , Q, and Ht are as defined herein. These compounds and pharmaceutically acceptable compositions thereof are useful for inhibiting kinases in vitro, in vivo, and ex vivo. Such uses include treating or preventing a variety of diseases, disorders or conditions, including, but not limited to, autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies and asthma, Alzheimer's disease, and hormone-related diseases. Other uses include the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

公开(公告)号：NO20082508A

公开(公告)日：2008-07-31

申请号：NO20082508

申请日：2008-05-30

Applicant: VERTEX PHARMA

Inventor： MORTIMORE MICHAEL PAUL ,  STUDLEY JOHN ,  BOYALL DEAN ,  FRAYSSE DAMIEN ,  ROBINSON DANIEL ,  BINCH HAYLEY ,  EVERITT SIMON ,  DAVIS CHRIS ,  RAMAYA SHARN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAR ,  PINDER JOANNE

IPC: C07D403/12 ,  A61K31/506 ,  A61P35/00 ,  C07D403/14 ,  C07D417/12

CPC classification number: C07D403/12 ,  C07D239/38 ,  C07D401/14 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

公开(公告)号：AU2006311797A1

公开(公告)日：2007-05-18

申请号：AU2006311797

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： ROBINSON DANIEL ,  O'DONNELL MICHAEL ,  STUDLEY JOHN ,  DAVIS CHRIS ,  RUTHERFORD ALISTAIR ,  MORTIMORE MICHAEL ,  BINCH HAYLEY ,  PINDER JOANNE ,  EVERITT SIMON ,  RAMAYA SHARN ,  MILIER ANDREW ,  FRAYSSE DAMIEN ,  BOYALL DEAN

IPC: A61K31/505 ,  C07D239/02

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

公开(公告)号：NZ594383A

公开(公告)日：2013-05-31

申请号：NZ59438306

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: C07D239/02 ,  A61K31/505

Abstract: ABSTRACT - 594383 Disclosed are aminopyrimidine compounds of formula (I), wherein the variables are as defined in the specification. These compounds are used for inhibiting Aurora protein kinase activity and are suitable for the treatment of a proliferative disorder selected from melanoma, myeloma, leukemia, lymphoma, neuroblastoma, or a cancer selected from colon, breast, gastric, ovarian, cervical, lung, central nervous system, renal, prostate, bladder, pancreatic, brain, head and neck, kidney, liver, melanoma, sarcoma, and thyroid cancer.

公开(公告)号：BRPI0619704A2

公开(公告)日：2011-10-11

申请号：BRPI0619704

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  DAVIS CHRIS ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  FRAYSSE DAMIEN ,  STUDLEY JOHN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: A61K31/505 ,  C07D239/02

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

公开(公告)号：NO20082508L

公开(公告)日：2008-07-31

申请号：NO20082508

申请日：2008-05-30

Applicant: VERTEX PHARMA

Inventor： MORTIMORE MICHAEL PAUL ,  STUDLEY JOHN ,  BOYALL DEAN ,  FRAYSSE DAMIEN ,  ROBINSON DANIEL ,  BINCH HAYLEY ,  EVERITT SIMON ,  DAVIS CHRIS ,  RAMAYA SHARN ,  MILIER ANDREW ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAR ,  PINDER JOANNE

IPC: A61K31/506 ,  C07D403/12 ,  A61P35/00 ,  C07D403/14 ,  C07D417/12

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.