公开(公告)号：AU2021358063A9

公开(公告)日：2025-03-13

申请号：AU2021358063

申请日：2021-10-06

Applicant: VERTEX PHARMA

Inventor： MCCARTNEY JASON ,  ABELA ALEXANDER RUSSELL ,  ABRAHAM SUNNY ,  ANDERSON COREY DON ,  ARUMUGAM VIJAYALAKSMI ,  CHAU JACLYN ,  CLEMENS JEREMY ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  DWIGHT TIMOTHY A ,  FANNING LEV TYLER DEWEY ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER (DECEASED) ,  GULEVICH ANTON V ,  HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KHATUYA HARIPADA ,  KRENITSKY PAUL ,  MELILLO VITO ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SILINA ALINA ,  TRAN JOE A ,  UY JOHNNY ,  VALDEZ LINO ,  ZHOU JINGLAN

IPC: C07D515/04 ,  A61K31/519 ,  A61P43/00

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：SI3946595T1

公开(公告)日：2024-02-29

申请号：SI202030331

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/00 ,  C07D515/00

公开(公告)号：RS65132B1

公开(公告)日：2024-02-29

申请号：RSP20240085

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

公开(公告)号：DK3946595T3

公开(公告)日：2024-01-22

申请号：DK20722087

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

公开(公告)号：AU2020328568A1

公开(公告)日：2022-03-03

申请号：AU2020328568

申请日：2020-08-13

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER RUSSELL ,  ANDERSON COREY DON ,  BOOKSER BRETT C ,  BUSCH BRETT B ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN ,  GHIRMAI SENAIT G ,  GULEVICH ANTON V ,  HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KHATUYA HARIPADA ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  TERMIN ANDREAS ,  SWIFT SARA E ,  ZHOU JINGLAN ,  UY JOHNNY ,  VOGEL CARL V

IPC: C07D513/22 ,  A61K31/435 ,  A61P11/00

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

公开(公告)号：ECSP21077043A

公开(公告)日：2021-12-30

申请号：ECDI202177043

申请日：2021-10-20

Applicant: VERTEX PHARMA

Inventor： ANDERSON COREY DON ,  VITO MELILLO ,  SILINA ALINA ,  HADIDA RUAH SARA SABINA ,  KRENITSKY PAUL ,  CLEMENS JEREMY ,  ABELA ALEXANDER RUSSELL ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  GROOTENHUIS PETER (FALLECIDO) ,  ABRAHAM SUNNY ,  CLEVELAND THOMAS ,  UY JOHNNY ,  ISHIHARA YOSHIHIRO ,  ZHOU JINGLAN ,  CHAU JACLYN ,  DWIGHT TIMOTHY A ,  ARUMUGAM VIJAYALAKSMI ,  FRIEMAN BRYAN A

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

Abstract: Se describen el compuesto I, derivados deuterados y sales farmacéuticamente aceptables de cualquiera de los precedentes. También se describen métodos para tratar la fibrosis cística utilizando dichos compuestos. (LA FORMULA SE APRECIA EN LA DESCRIPCION TECNICA)

公开(公告)号：CA3135842A1

公开(公告)日：2020-10-08

申请号：CA3135842

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER RUSSELL ,  ABRAHAM SUNNY ,  ANDERSON COREY DON ,  ARUMUGAM VIJAYALAKSMI ,  CHAU JACLYN ,  CLEMENS JEREMY ,  CLEVELAND THOMAS ,  DWIGHT TIMOTHY A ,  FRIEMAN BRYAN A ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

Abstract: Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

公开(公告)号：AU2020252367B2

公开(公告)日：2025-04-17

申请号：AU2020252367

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER RUSSELL ,  ABRAHAM SUNNY ,  ANDERSON COREY DON ,  ARUMUGAM VIJAYALAKSMI ,  CHAU JACLYN ,  CLEMENS JEREMY ,  CLEVELAND THOMAS ,  DWIGHT TIMOTHY A ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER ,  HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: C07D239/69 ,  A61P11/00 ,  C07D515/08

Abstract: Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

公开(公告)号：IL316422A

公开(公告)日：2024-12-01

申请号：IL31642224

申请日：2024-10-16

Applicant: VERTEX PHARMA ,  MILLER MARK THOMAS ,  HURLEY DENNIS JAMES ,  NEUBERT TIMOTHY DONALD ,  NESAN SAVARIAR ELAMPRAKASH ,  PATEL URVI ,  HADIDA RUAH SARA SABINA ,  MCCARTNEY JASON ,  ZHOU JINGLAN ,  DEMORET ROBERT MARTIN ,  VALIULIN ROMAN ASKATOVICH ,  KINTZER ALEXANDER FREDERIK ,  WEBB PETER ,  SLOCHOWER DAVID ROBERT ,  AERTGEERTS KATHLEEN ,  BECK ELIZABETH MARY ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  CHUDYK EWA IWONA ,  PINDER JOANNE LOUISE ,  GULEVICH ANTON V ,  ISHIHARA YOSHIHIRO ,  TRAN JOE A ,  SCHARF ADAM

Inventor： MILLER MARK THOMAS ,  HURLEY DENNIS JAMES ,  NEUBERT TIMOTHY DONALD ,  NESAN SAVARIAR ELAMPRAKASH ,  PATEL URVI ,  HADIDA RUAH SARA SABINA ,  MCCARTNEY JASON ,  ZHOU JINGLAN ,  DEMORET ROBERT MARTIN ,  VALIULIN ROMAN ASKATOVICH ,  KINTZER ALEXANDER FREDERIK ,  WEBB PETER ,  SLOCHOWER DAVID ROBERT ,  AERTGEERTS KATHLEEN ,  BECK ELIZABETH MARY ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  CHUDYK EWA IWONA ,  PINDER JOANNE LOUISE ,  GULEVICH ANTON V ,  ISHIHARA YOSHIHIRO ,  TRAN JOE A ,  SCHARF ADAM

IPC: A61P25/02 ,  A61P29/00

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：HUE064849T2

公开(公告)日：2024-04-28

申请号：HUE20722087

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08