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公开(公告)号：UY39456A
公开(公告)日：2022-05-31
申请号：UY39456
申请日：2021-10-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , SARA SABINA HADIDA RUAH , CLEVELAND THOMAS , BRYAN A FRIEMAN , ZHOU JINGLAN , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , MCCARTNEY JASON , ABRAHAM SUNNY , COREY DON ANDERSON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , TIMOTHY A DWIGHT , ISHIHARA YOSHIHIRO , SILINA ALINA
IPC: A61K31/36 , A61K31/404 , A61K31/443 , A61K31/47 , A61K31/519 , A61P11/00 , C07D515/04 , C07D515/14
Abstract: Esta descripción proporciona moduladores del regulador de conductancia transmembranario de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística mediante el uso de tales moduladores y composiciones farmacéuticas, y procesos para producir tales moduladores
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2.发明专利
公开(公告)号：CO2021014204A2
公开(公告)日：2021-10-29
申请号：CO2021014204
申请日：2021-10-25
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , ANDERSON COREY DON , CLEVELAND THOMAS , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , ABRAHAM SUNNY , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , DWIGHT TIMOTHY A , FRIEMAN BRYAN A , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MELILLO VITO , SILINA ALINA , UY JOHNNY
IPC: A61P11/00 , C07D239/69 , C07D515/08
Abstract: Se describen el compuesto I, derivados deuterados y sales farmacéuticamente aceptables de cualquiera de los precedentes. También se describen métodos para tratar la fibrosis cística utilizando dichos compuestos.
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公开(公告)号：CA3019380A1
公开(公告)日：2017-10-05
申请号：CA3019380
申请日：2017-03-31
Applicant: VERTEX PHARMA
Inventor： BEAR BRIAN , CLEMENS JEREMY , CLEVELAND THOMAS , COON TIMOTHY RICHARD , GROOTENHUIS PETER DIEDERIK JAN , FRIEMAN BRYAN A , HADIDA RUAH SARA S , KHATUYA HARIPADA , KRENITSKY PAUL J , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/44 , A61P11/00 , C07D213/82
Abstract: The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：AU2021358063A9
公开(公告)日：2025-03-13
申请号：AU2021358063
申请日：2021-10-06
Applicant: VERTEX PHARMA
Inventor： MCCARTNEY JASON , ABELA ALEXANDER RUSSELL , ABRAHAM SUNNY , ANDERSON COREY DON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , CLEVELAND THOMAS , COON TIMOTHY RICHARD , DWIGHT TIMOTHY A , FANNING LEV TYLER DEWEY , FRIEMAN BRYAN A , GROOTENHUIS PETER (DECEASED) , GULEVICH ANTON V , HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KHATUYA HARIPADA , KRENITSKY PAUL , MELILLO VITO , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SILINA ALINA , TRAN JOE A , UY JOHNNY , VALDEZ LINO , ZHOU JINGLAN
IPC: C07D515/04 , A61K31/519 , A61P43/00
Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
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5.发明专利
公开(公告)号：ECSP21077043A
公开(公告)日：2021-12-30
申请号：ECDI202177043
申请日：2021-10-20
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY DON , VITO MELILLO , SILINA ALINA , HADIDA RUAH SARA SABINA , KRENITSKY PAUL , CLEMENS JEREMY , ABELA ALEXANDER RUSSELL , MCCARTNEY JASON , MILLER MARK THOMAS , GROOTENHUIS PETER (FALLECIDO) , ABRAHAM SUNNY , CLEVELAND THOMAS , UY JOHNNY , ISHIHARA YOSHIHIRO , ZHOU JINGLAN , CHAU JACLYN , DWIGHT TIMOTHY A , ARUMUGAM VIJAYALAKSMI , FRIEMAN BRYAN A
IPC: A61P11/00 , C07D239/69 , C07D515/08
Abstract: Se describen el compuesto I, derivados deuterados y sales farmacéuticamente aceptables de cualquiera de los precedentes. También se describen métodos para tratar la fibrosis cística utilizando dichos compuestos. (LA FORMULA SE APRECIA EN LA DESCRIPCION TECNICA)
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Patent Agency Ranking
公开(公告)号：AU2017240685B2
公开(公告)日：2021-08-12
申请号：AU2017240685
申请日：2017-03-31
Applicant: VERTEX PHARMA
Inventor： BEAR BRIAN , CLEMENS JEREMY , CLEVELAND THOMAS , COON TIMOTHY RICHARD , GROOTENHUIS PETER DIEDERIK JAN , FRIEMAN BRYAN A , HADIDA RUAH SARA S , KHATUYA HARIPADA , KRENITSKY PAUL J , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/44 , A61P11/00 , C07D213/82
Abstract: The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R
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公开(公告)号：ES2837431T3
公开(公告)日：2021-06-30
申请号：ES17826629
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL , BAEK MINSON , CLEMENS JEREMY , CLEVELAND THOMAS , FERRIS LORI , GROOTENHUIS PETER DIEDERIK , GROSS RAYMOND , GULEVICH ANTON , HADIDA RUAH SARA , HSIA CLARA , HUGHES ROBERT , JOSHI PRAMOD , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL , MCCARTNEY JASON , MILLER MARK , PARASELLI PRASUNA , PIERRE FABRICE JEAN , SHI YI , SHRESTHA MUNA , SIESEL DAVID , STAVROPOULOS KATHY , TERMIN ANDREAS , UY JOHNNY , VAN GOOR FREDRICK , YOUNG TOMOTHY , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Un compuesto que tiene la fórmula siguiente: **(Ver fórmula)** una sal farmacéuticamente aceptable del mismo, o un derivado deuterado de cualquiera de los anteriores.
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公开(公告)号：CA3135842A1
公开(公告)日：2020-10-08
申请号：CA3135842
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ABRAHAM SUNNY , ANDERSON COREY DON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , CLEVELAND THOMAS , DWIGHT TIMOTHY A , FRIEMAN BRYAN A , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: A61P11/00 , C07D239/69 , C07D515/08
Abstract: Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
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公开(公告)号：AU2020252367B2
公开(公告)日：2025-04-17
申请号：AU2020252367
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ABRAHAM SUNNY , ANDERSON COREY DON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , CLEVELAND THOMAS , DWIGHT TIMOTHY A , FRIEMAN BRYAN A , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: C07D239/69 , A61P11/00 , C07D515/08
Abstract: Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
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公开(公告)号：UY39458A
公开(公告)日：2022-05-31
申请号：UY39458
申请日：2021-10-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , SARA SABINA HADIDA RUAH , CLEVELAND THOMAS , BRYAN A FRIEMAN , KHATUYA HARIPADA , ZHOU JINGLAN , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , MCCARTNEY JASON , ABRAHAM SUNNY , COREY DON ANDERSON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , TIMOTHY A DWIGHT , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , PIERRE FABRICE , SILINA ALINA , TIMOTHY RICHARD COON , JOE A TRAN , PARASELLI PRASUNA
IPC: A61K31/36 , A61K31/404 , A61K31/443 , A61K31/47 , A61K31/519 , A61P11/00 , C07D515/04 , C07D515/14
Abstract: Esta descripción proporciona moduladores del regulador de conductancia transmembranario de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística mediante el uso de tales moduladores y composiciones farmacéuticas, y procesos para producir tales moduladores
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