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公开(公告)号：WO2006023852A3
公开(公告)日：2006-08-31
申请号：PCT/US2005029780
申请日：2005-08-19
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
IPC: A61K31/435 , A61K31/438 , A61P25/00 , A61P43/00 , C07D471/00
CPC classification number: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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2.发明申请MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 审中-公开CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂
公开(公告)号：WO2010048526A3
公开(公告)日：2010-09-16
申请号：PCT/US2009061882
申请日：2009-10-23
Applicant: VERTEX PHARMA , BINCH HAYLEY , FANNING LEV T D , HURLEY DENNIS , SHETH URVI , SILINA ALINA , YANG XIAOQING , BOTFIELD MARTYN , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL
Inventor： BINCH HAYLEY , FANNING LEV T D , HURLEY DENNIS , SHETH URVI , SILINA ALINA , YANG XIAOQING , BOTFIELD MARTYN , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL
IPC: C07D451/02 , A61K31/439 , A61P11/00
CPC classification number: A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1856 , G01N33/5041 , G01N33/6872 , G01N2800/382
Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. (l); or pharmaceutically acceptable salts thereof, wherein: ring A is selected from:
Abstract translation: 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR的调节剂治疗疾病的方法。 （升）; 或其药学上可接受的盐，其中：环A选自：
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3.发明申请4-OXO-1H-QUINOLINE-3-CARBOXAMIDES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 审中-公开作为ATP结合蛋白转运蛋白的调节剂的4-OXO-1H-喹啉-3-羧酰胺
公开(公告)号：WO2011072241A9
公开(公告)日：2012-06-14
申请号：PCT/US2010059920
申请日：2010-12-10
Applicant: VERTEX PHARMA , SHETH URVI , FANNING LEV T D , NUMA MEHDI , BINCH HAYLEY , HURLEY DENNIS JAMES , ZHOU JINGLAN , HADIDA RUAH SARA S , HAZLEWOOD ANNA R , SILINA ALINA , VAIRAGOUNDAR RAJENDRAN , VAN GOOR FREDRICK F , GROOTENHUIS PETER DIEDERIK JAN , BOTFIELD MARTYN C
Inventor： SHETH URVI , FANNING LEV T D , NUMA MEHDI , BINCH HAYLEY , HURLEY DENNIS JAMES , ZHOU JINGLAN , HADIDA RUAH SARA S , HAZLEWOOD ANNA R , SILINA ALINA , VAIRAGOUNDAR RAJENDRAN , VAN GOOR FREDRICK F , GROOTENHUIS PETER DIEDERIK JAN , BOTFIELD MARTYN C
IPC: C07D215/56 , A61K31/4709 , A61P11/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/08
CPC classification number: C07C215/76 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/42 , C07D209/94 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/38 , C07D215/56 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/10
Abstract: The present invention relates to 4-oxo-1H-quinoline-3-carboxamides as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Abstract translation: 本发明涉及作为ATP结合盒（“ABC”）转运体或其片段的调节剂的4-氧代-1H-喹啉-3-甲酰胺，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：WO2007076070A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049141
申请日：2006-12-22
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
CPC classification number: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2006058294A2
公开(公告)日：2006-06-01
申请号：PCT/US2005042931
申请日：2005-11-29
Applicant: VERTEX PHARMA , HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
Inventor： HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
CPC classification number: C07D211/10 , A61K31/4439 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/52 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12 , C07D451/02 , C07D493/08
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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Patent Agency Ranking
公开(公告)号：FI3946595T3
公开(公告)日：2024-01-18
申请号：FI20722087
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA SABINA , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: A61P11/00 , C07D239/69 , C07D515/08
Abstract: Compound I, deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
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公开(公告)号：JOP20210268A1
公开(公告)日：2023-01-30
申请号：JOP20210268
申请日：2020-04-02
Applicant: VERTEX PHARMA
Inventor： FRIEMAN BRYAN A , MELILLO VITO , UY JOHNNY , ANDERSON COREY DON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , ABRAHAM SUNNY , ABELA ALEXANDER RUSSELL , ARUMUGAM VIJAYALAKSMI , ISHIHARA YOSHIHIRO , CHAU JACLYN , ZHOU JINGLAN , DWIGHT TIMOTHY A , SILINA ALINA , KRENITSKY PAUL , CLEVELAND THOMAS , CLEMENS JEREMY , MCCARTNEY JASON , MILLER MARK THOMAS
Abstract: غيرمتوفر
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公开(公告)号：UY39460A
公开(公告)日：2022-05-31
申请号：UY39460
申请日：2021-10-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , SARA SABINA HADIDA RUAH , CLEVELAND THOMAS , BRYAN A FRIEMAN , KHATUYA HARIPADA , MELILLO VITO , ZHOU JINGLAN , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , UY JOHNNY , MCCARTNEY JASON , ABRAHAM SUNNY , COREY DON ANDERSON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , TIMOTHY A DWIGHT , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , PIERRE FABRICE , SILINA ALINA , TIMOTHY RICHARD COON , LEV TYLER DEWEY FANNING , ANTON V GULEVICH , JOE A TRAN , VALDEZ LINO , PARASELLI PRASUNA
IPC: A61K31/36 , A61K31/404 , A61K31/443 , A61K31/47 , A61K31/519 , A61P11/00 , C07D515/04
Abstract: Esta descripción proporciona moduladores del regulador de conductancia transmembranario de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística mediante el uso de tales moduladores y composiciones farmacéuticas, y procesos para producir tales moduladores
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公开(公告)号：UY39459A
公开(公告)日：2022-05-31
申请号：UY39459
申请日：2021-10-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , SARA SABINA HADIDA RUAH , CLEVELAND THOMAS , BRYAN A FRIEMAN , ZHOU JINGLAN , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , MCCARTNEY JASON , ABRAHAM SUNNY , COREY DON ANDERSON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , TIMOTHY A DWIGHT , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , PIERRE FABRICE , SILINA ALINA , TIMOTHY RICHARD COON , LEV TYLER DEWEY FANNING , JOE A TRAN , VALDEZ LINO , DINH ANDREW
IPC: A61K31/36 , A61K31/404 , A61K31/443 , A61K31/47 , A61K31/519 , A61K31/55 , A61P11/00 , C07D515/14
Abstract: Esta descripción proporciona moduladores del regulador de conductancia transmembranario de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística mediante el uso de tales moduladores y composiciones farmacéuticas, y procesos para producir tales moduladores
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公开(公告)号：UY39457A
公开(公告)日：2022-05-31
申请号：UY39457
申请日：2021-10-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , SARA SABINA HADIDA RUAH , CLEVELAND THOMAS , BRYAN A FRIEMAN , KHATUYA HARIPADA , MELILLO VITO , ZHOU JINGLAN , ALEXANDER RUSSELL ABELA , MARK THOMAS MILLER , UY JOHNNY , MCCARTNEY JASON , ABRAHAM SUNNY , COREY DON ANDERSON , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , TIMOTHY A DWIGHT , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , PIERRE FABRICE , SILINA ALINA , TIMOTHY RICHARD COON , LEV TYLER DEWEY FANNING , ANTON V GULEVICH , JOE A TRAN , VALDEZ LINO , VICKERS TROY , PARASELLI PRASUNA
IPC: A61K31/36 , A61K31/404 , A61K31/443 , A61K31/47 , A61K31/519 , A61P11/00 , C07D515/04
Abstract: Esta descripción proporciona moduladores del regulador de conductancia transmembranario de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística mediante el uso de tales moduladores y composiciones farmacéuticas, y procesos para producir tales moduladores
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