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公开(公告)号：NZ719729A
公开(公告)日：2022-04-29
申请号：NZ71972914
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： ASMAL MOHAMMED , LEDEBOER MARK , MEDEK ALES , MUDUNURI PRAVEEN , WALDO MICHAEL , O’NEIL SIMON , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME , MACIKENAS DAINIUS , SHI YI , JURKAUSKAS VALDAS , JONES STEVEN , BYRN RANDAL , ROBERTSON SARAH , TSAI WANJUNG
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2Η20, Form F of HCl salt of Compound (1)·3Η20, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.
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公开(公告)号：HRP20191525T1
公开(公告)日：2019-11-29
申请号：HRP20191525
申请日：2019-08-26
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
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公开(公告)号：HUE044667T2
公开(公告)日：2019-11-28
申请号：HUE14802787
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , WALDO MICHAEL , O'NEIL SIMON , VAN ALSTEN JOHN , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH , TSAI WANJUNG
IPC: A61P31/16
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公开(公告)号：AU2014348840A1
公开(公告)日：2016-05-26
申请号：AU2014348840
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2&EEgr;
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公开(公告)号：SI3068776T1
公开(公告)日：2019-09-30
申请号：SI201431295
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
IPC: C07D403/00 , A61K31/00 , A61P31/00 , C07D471/00
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Patent Agency Ranking
公开(公告)号：RS59144B1
公开(公告)日：2019-09-30
申请号：RSP20191054
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
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公开(公告)号：DK3068776T3
公开(公告)日：2019-07-29
申请号：DK14802787
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： WALDO MICHAEL , O'NEIL SIMON ADAM , MACIKENAS DAINIUS , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG , NTI-ADDAE KWAME W , VAN ALSTEN JOHN GREGG , MUDUNURI PRAVEEN
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
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公开(公告)号：ES2741444T3
公开(公告)日：2020-02-11
申请号：ES14802787
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , WALDO MICHAEL , O'NEIL SIMON , VAN ALSTEN JOHN , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH , TSAI WANJUNG
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
Abstract: Una forma polimórfica del compuesto (1), en donde el compuesto (1) está representado por la siguiente fórmula estructural:**Fórmula** y donde la forma polimórfica es una sal cristalina de HCl del semihidrato del compuesto (1), estando dicha forma polimórfica caracterizada además por uno o más picos que corresponden a valores de 2-theta medidos en grados de 10,5 ± 0 10 ,2, 5,2 ± 0,2, 7,4 ± 0,2 y 18,9 ± 0,2 en un patrón de difracción de rayos X en polvo.
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公开(公告)号：PL3068776T3
公开(公告)日：2019-10-31
申请号：PL14802787
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
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公开(公告)号：AU2014348840B2
公开(公告)日：2019-06-06
申请号：AU2014348840
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2Η
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