Patent search ap:("VERTEX PHARMA") AND inv:"BYRN RANDAL" Page 1

1.

发明申请
COMPOSITIONA AND METHODS USEFUL FOR HCV INFECTION 审中-公开
Title translation: 用于HCV感染的组合物和方法

公开(公告)号：WO02077206A9

公开(公告)日：2004-02-19

申请号：PCT/US0209685

申请日：2002-03-27

Applicant: VERTEX PHARMA , KWONG ANN , BYRN RANDAL , REID LOLA M

Inventor： KWONG ANN , BYRN RANDAL , REID LOLA M

IPC: G01N33/50 , C12N5/071 , C12N7/00 , C12N15/09 , C12Q1/68 , G01N33/15 , C12N5/00 , C12N15/85 , C12N15/86 , C12Q1/70

CPC classification number: C12Q1/70 , C12N5/0031 , C12N5/0037 , C12N5/067 , C12N7/00 , C12N2500/20 , C12N2500/25 , C12N2500/36 , C12N2500/46 , C12N2500/90 , C12N2501/11 , C12N2501/12 , C12N2501/18 , C12N2501/335 , C12N2501/375 , C12N2501/39 , C12N2502/11 , C12N2770/24011

Abstract: The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for injecting the cells in the composition with HCV. The present invention also provides methods for assaying HCV production and methods for evaluating compounds that affect the production of HCV.

Abstract translation: 本发明提供了包含能够在HCV感染后有效产生HCV的细胞的组合物，用于培养细胞的组合物，用于制备组合物的方法和用HCV注射组合物中的细胞的方法。本发明还提供了用于测定HCV产生的方法以及评价影响HCV产生的化合物的方法。

2.

发明公开
COMPOSITIONA AND METHODS USEFUL FOR HCV INFECTION 有权
Title translation: HIV感染的合适的组合物和方法

公开(公告)号：EP1381673A4

公开(公告)日：2004-11-10

申请号：EP02753872

申请日：2002-03-27

Applicant: VERTEX PHARMA

Inventor： KWONG ANN , BYRN RANDAL , REID LOLA M

IPC: G01N33/50 , C12N5/071 , C12N7/00 , C12N15/09 , C12Q1/68 , G01N33/15 , C12N5/00 , C12N15/85 , C12N15/86 , C12Q1/70

CPC classification number: C12Q1/70 , C12N5/0031 , C12N5/0037 , C12N5/067 , C12N7/00 , C12N2500/20 , C12N2500/25 , C12N2500/36 , C12N2500/46 , C12N2500/90 , C12N2501/11 , C12N2501/12 , C12N2501/18 , C12N2501/335 , C12N2501/375 , C12N2501/39 , C12N2502/11 , C12N2770/24011

3.

发明专利
Inhibitors of influenza viruses replication 未知

公开(公告)号：NZ719729A

公开(公告)日：2022-04-29

申请号：NZ71972914

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： ASMAL MOHAMMED , LEDEBOER MARK , MEDEK ALES , MUDUNURI PRAVEEN , WALDO MICHAEL , O’NEIL SIMON , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME , MACIKENAS DAINIUS , SHI YI , JURKAUSKAS VALDAS , JONES STEVEN , BYRN RANDAL , ROBERTSON SARAH , TSAI WANJUNG

IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04

Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2Η20, Form F of HCl salt of Compound (1)·3Η20, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.