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    SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG
    1.
    发明申请
    SOLID FORMS OF A THIOPHOSPHORAMIDATE NUCLEOTIDE PRODRUG 审中-公开
    硫代磷酸酯核苷酸固体形式

    公开(公告)号：WO2013142124A1

    公开(公告)日：2013-09-26

    申请号：PCT/US2013030267

    申请日：2013-03-11

    Applicant: VERTEX PHARMA

    Inventor： KULDIPKUMAR ANUJ K ,  MEDEK ALES ,  FERRIS LORI ANN ,  MUDUNURI PRAVEEN ,  JUNG YOUNG CHUN ,  WILLCOX DAVID RICHARD ,  WALDO MICHAEL ,  NUGENT WILLIAM ALOYSIUS

    IPC: C07H19/06 ,  A61K31/7072 ,  A61P31/14

    CPC classification number: C07H19/10 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  C07B2200/13 ,  C07H19/06 ,  A61K2300/00

    Abstract: The present application relates to solid state forms, for example, crystalline forms of 2'- C-methyluridine-5 '-(O-phenyl-N-(S)- 1 -(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2'-C-methyluridine-5'- (0-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2'-C-methyluridine-5'- (O-phenyl-N-(S)- 1 -(isopropoxy carbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2'-C- methyluridine-5 '-(O-phenyl-N-(S)- 1 -(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.

    Abstract translation: 本申请涉及固体形式，例如2'-C-甲基尿苷-5' - （O-苯基-N-（S）-1-（异丙氧基羰基）乙基）硫代磷酰胺的结晶形式，可以包括 一种或多种固体形式的2'-C-甲基尿苷-5'-（O-苯基-N-（S）-1-（异丙氧基羰基）乙基）硫代氨基磷酸酯，以及用一种或多种硫代磷酸酰胺酯治疗或改善疾病和/或病症的方法 更多固体形式的2'-C-甲基尿苷-5'-（O-苯基-N-（S）-1-（异丙氧基羰基）乙基）硫代磷酰胺。 本文还公开的是使用一种或多种固体形式的2'-C-甲基尿苷-5' - （O-苯基-N-（S）-1-（异丙氧基羰基）乙基）硫代磷酰胺的组合治疗疾病和/或病症的方法 与一个或多个其他代理。

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