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公开(公告)号：NO20031192L
公开(公告)日：2003-05-13
申请号：NO20031192
申请日：2003-03-14
Applicant: VERTEX PHARMA
Inventor： HALE MICHAEL , JANETKA JAMES , MALTAIS FRANCOIS , CAO JINGRONG , MASHAL ROBERT
IPC: A61K31/42 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/14
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公开(公告)号：NO20031192A
公开(公告)日：2003-05-13
申请号：NO20031192
申请日：2003-03-14
Applicant: VERTEX PHARMA
Inventor： HALE MICHAEL , JANETKA JAMES , MALTAIS FRANCOIS , CAO JINGRONG , MASHAL ROBERT
IPC: A61K31/42 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/14
CPC classification number: C07D413/14 , C07D413/04 , C07D417/14
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公开(公告)号：HK1052934A1
公开(公告)日：2003-10-03
申请号：HK03105158
申请日：2003-07-16
Applicant: VERTEX PHARMA
Inventor： HALE MICHAEL , JANETKA JAMES , MALTAIS FRANCOIS , CAO JINGRONG , MASHAL ROBERT
IPC: C07D20060101 , A61K20060101 , A61K31/42 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P20060101 , A61P1/00 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/14
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公开(公告)号：CA2422376A1
公开(公告)日：2002-03-21
申请号：CA2422376
申请日：2001-09-14
Applicant: VERTEX PHARMA
Inventor： HALE MICHAEL , JANETKA JAMES , MASHAL ROBERT , MALTAIS FRANCOIS , CAO JINGRONG
IPC: A61K31/42 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/439 , A61K31/497
Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula (I) wherein Ht is an optionally substituted heteroaryl ring selected from pyrrol-3-yl, pyrazol-3- yl, [1,2,3]triazol-4-yl, or tetrazol-5-yl, and A-B is N-O or O-N. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
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公开(公告)号：AU2006201392B2
公开(公告)日：2008-05-15
申请号：AU2006201392
申请日：2006-04-04
Applicant: VERTEX PHARMA
Inventor： JANETKA JAMES , CAO JINGRONG , MALTAIS FRANCOIS , HALE MICHAEL , MASHAL ROBERT
IPC: C07D413/04 , A61K31/422 , A61K31/433 , A61K31/439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61P35/00 , C07D413/14 , C07D417/14
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Patent Agency Ranking
公开(公告)号：HK1052934B
公开(公告)日：2007-01-12
申请号：HK03105158
申请日：2003-07-16
Applicant: VERTEX PHARMA
Inventor： HALE MICHAEL , JANETKA JAMES , MALTAIS FRANCOIS , CAO JINGRONG , MASHAL ROBERT
IPC: C07D20060101 , A61K20060101 , A61K31/42 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P20060101 , A61P1/00 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/14
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公开(公告)号：AU2006201392A1
公开(公告)日：2006-04-27
申请号：AU2006201392
申请日：2006-04-04
Applicant: VERTEX PHARMA
Inventor： JANETKA JAMES , CAO JINGRONG , MALTAIS FRANCOIS , HALE MICHAEL , MASHAL ROBERT
IPC: C07D413/04 , A61K31/422 , A61K31/433 , A61K31/439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61P35/00 , C07D413/14 , C07D417/14
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公开(公告)号：NZ525016A
公开(公告)日：2004-10-29
申请号：NZ52501601
申请日：2001-09-14
Applicant: VERTEX PHARMA
Inventor： HALE MICHAEL , JANETKA JAMES , MALTAIS FRANCOIS , CAO JINGRONG , MASHAL ROBERT
IPC: A61K31/42 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/439 , A61K31/497
Abstract: Disclosed herein are compounds of formula (I) that are useful as protein kinase inhibitors, especially inhibitors of ERK, wherein Ht is an optionally substituted heteroaryl ring selected from pyrrol-3-yl, pyrazol-3-yl, [1,2,3]triazol-4-yl, [1,2,4]triazol-3-yl, or tetrazol-5-yl, and A-B is N-O or O-N, and wherein R1, R2 and T are as defined in the specification. These compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
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公开(公告)号：DE60122176T2
公开(公告)日：2007-07-05
申请号：DE60122176
申请日：2001-09-14
Applicant: VERTEX PHARMA
Inventor： HALE MICHAEL , JANETKA JAMES , MALTAIS FRANCOIS , CAO JINGRONG , MASHAL ROBERT
IPC: C07D413/04 , A61K31/42 , A61K31/422 , A61K31/433 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07D413/14 , C07D417/14
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公开(公告)号：NO322745B1
公开(公告)日：2006-12-04
申请号：NO20014837
申请日：2001-10-04
Applicant: VERTEX PHARMA
Inventor： BEMIS GUY W , GREEN JEREMY , CAO JINGRONG , HALE MICHAEL , BAKER CHRISTOPHER , MALTAIS FRANCOIS , JAMES JANETKA , MULLICAN MICHAEL , XIE XIAOLING , STRAUB JUDITH , TANG QING , MASHAL ROBERT
IPC: A61B17/00 , C07D403/04 , A61F2/02 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/00 , A61L27/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P13/00 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P21/00 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D231/38 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R 1-4 , Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
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