公开(公告)号：ZA200808646B

公开(公告)日：2009-07-29

申请号：ZA200808646

申请日：2008-10-09

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  MINZHANG CHEN ,  CHUN JUNG YOUNG ,  FORSLUND RAYMOND E

IPC: C07C20090101 ,  C07D20090101

公开(公告)号：AU2005223767B2

公开(公告)日：2011-12-01

申请号：AU2005223767

申请日：2005-03-11

Applicant: VERTEX PHARMA

Inventor： MINZHANG CHEN ,  JONES ANDREW D ,  TANOURY GERALD J ,  SNOONIAN JOHN R ,  NYCE PHILIP L ,  MARTIN TRUDEAU ,  GUERIN DAVID J

IPC: C07B43/04 ,  C07B57/00 ,  C07D405/12

Abstract: The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.

公开(公告)号：BRPI0508609B8

公开(公告)日：2021-05-25

申请号：BRPI0508609

申请日：2005-03-11

Applicant: VERTEX PHARMA

Inventor： ANDREW D JONES ,  DAVID J GUERIN ,  GERALD J TANOURY ,  JOHN R SNOONIAN ,  MARTIN TRUDEAU ,  MINZHANG CHEN ,  PHILIP L NYCE

IPC: C07B43/04 ,  C07B57/00 ,  C07D405/12

Abstract: processos e intermediários. a invenção se refere a processos e a compostos úteis para produzir derivados do ácido aspártico modificados, tais como porções aldeídicas do ácido aspártico. derivados do ácido aspártico são úteis para preparar inibidores da caspase e/ou seus pró medicamentos.

公开(公告)号：BRPI0508609B1

公开(公告)日：2021-03-30

申请号：BRPI0508609

申请日：2005-03-11

Applicant: VERTEX PHARMA

Inventor： ANDREW D JONES ,  DAVID J GUERIN ,  GERALD J TANOURY ,  JOHN R SNOONIAN ,  MARTIN TRUDEAU ,  MINZHANG CHEN ,  PHILIP L NYCE

IPC: C07B43/04 ,  C07B57/00 ,  C07D405/12

Abstract: processos e intermediários. a invenção se refere a processos e a compostos úteis para produzir derivados do ácido aspártico modificados, tais como porções aldeídicas do ácido aspártico. derivados do ácido aspártico são úteis para preparar inibidores da caspase e/ou seus pró medicamentos.

公开(公告)号：ZA200607605B

公开(公告)日：2009-04-29

申请号：ZA200607605

申请日：2006-09-11

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  JONES ANDREW D ,  MARTIN TRUDEAU ,  SNOONIAN JOHN R ,  MINZHANG CHEN ,  NYCE PHILIP L ,  GUERIN DAVID J

IPC: C07B20090101 ,  C07B43/04 ,  C07B57/00 ,  C07D20090101 ,  C07D405/12

Abstract: The invention relates to a process of producing a compound of comprising purifying a mixture of wherein R 8 is a protecting group, and purifying includes chromatographing, selectively crystallizing, or dynamically crystallizing the mixture.

公开(公告)号：PT1934179E

公开(公告)日：2010-07-12

申请号：PT06813568

申请日：2006-08-18

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  MINZHANG CHEN ,  COCHRAN JOHN E

IPC: C07D209/52

公开(公告)号：ZA200808645B

公开(公告)日：2009-07-29

申请号：ZA200808645

申请日：2008-10-09

Applicant: VERTEX PHARMA

Inventor： PERNI ROBERT B ,  MINZHANG CHEN ,  CHUN JUNG YOUNG ,  FORSLUND RAYMOND E ,  TANOURY GERALD J ,  YOUSSEF BENNANI ,  GREGOR ZLOKARNIK ,  FRANCOIS MALTAIS

IPC: A61K20090101 ,  A61P20090101 ,  C07C20090101 ,  C07D20090101

公开(公告)号：ZA200801791B

公开(公告)日：2008-12-31

申请号：ZA200801791

申请日：2008-02-25

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  COCHRAN JOHN E ,  MINZHANG CHEN

IPC: A61K20090101 ,  C07D20090101

Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.