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公开(公告)号：BR112022019792A2
公开(公告)日：2022-12-06
申请号：BR112022019792
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： SIMON GIROUX , MICHAEL PHILIP CLARK , MICHAEL AARON BRODNEY , PHILIPPE MARCEL NUHANT , EMILY ELIZABETH ALLEN , ROBERT FRANCIS FIMOGNARI JR , MARIAM ZAKY , MICHAEL JOHN BOYD , DAVID D DEININGER , HU ZHANG , HONGBO DENG , PHILIP NOEL COLLIER , BRAD MAXWELL , NATHAN D WAAL , STEVEN M RONKIN , QING TANG , JIAN WANG , PETER JONES , GABRIELLE SIMONE FLEMING , LEV T D FANNING , DIANE MARIE BOUCHER , DENNIS JAMES HURLEY , AMY B HALL , JOHN PATRICK MAXWELL , MAC ARTHUR JOHNSON JR , TIMOTHY LEWIS TAPLEY , REBECCA JANE SWETT , VERONIQUE DAMAGNEZ , STEPHEN A THOMSON , UPUL KEERTHI BANDARAGE , KEVIN MICHAEL COTTRELL
IPC: C07D209/08 , A61K31/35 , A61K31/381 , A61K31/404 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D209/18 , C07D209/20 , C07D209/30 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D493/08
Abstract: DERIVADOS DE INDOL COMO MODULADORES DE ALFA-1-ANTITRIPSINA PARA TRATAMENTO DA DEFICIÊNCIA DE ALFA-1-ANTITRIPSINA (AATD). Derivados de indol como moduladores de alfa-1-antitripsina para tratar a deficiência de alfa-1-antitripsina (AATD).
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公开(公告)号：HK1252425A1
公开(公告)日：2019-05-24
申请号：HK18111726
申请日：2018-09-12
Applicant: VERTEX PHARMA
Inventor： ROBERT J DAVIES , JINGRONG CAO , MEGHAN ELISE COCKERILL , PHILIP NOEL COLLIER , MICHAEL PAUL DENINNO , ELISABETH DOYLE , JAMES DANIEL FRANTZ , HUAI GAO , BRIAN ANTHONY GOLDMAN , RONALD LEE GREY , ANNE-LAURE GRILLOT , WENXIN GU , JAMES A HENDERSON , RAUL EDUARDO KRAUSS , ADRIANNE LYNN KOLPAK , YUSHENG LIAO , SANJAY SHIVAYOGI MAGAVI , FRANCOIS MALTAIS , DAVID MESSERSMITH , ALBERT CHARLES PIERCE , EMANUELE PEROLA , ELIZABETH JIN-SUN RYU , JOSHUA SYKEN , JIAN WANG
IPC: A61K20060101 , A61P20060101 , C07D20060101
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