公开(公告)号：AU2021213758A1

公开(公告)日：2022-09-01

申请号：AU2021213758

申请日：2021-01-28

Applicant: VERTEX PHARMA

Inventor： CAO JINGRONG ,  COME JON H ,  DAKIN LESLIE A ,  DENIS FRANCOIS ,  DORSCH WARREN A ,  FORTIER ANNE ,  HAMEL MARTINE ,  KRUEGER ELAINE B ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  NANTHAKUMAR SUGANTHINI S ,  NICOLAS OLIVIER ,  SAYEGH CAMIL E ,  SENTER TIMOTHY J ,  WANG TIANSHENG

IPC: C07D209/12 ,  A61K31/404 ,  A61P13/12 ,  C07D209/18 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D413/12

Abstract: The disclosure provides at least one entity chosen from compounds of Formula (I) pharmaceutically acceptable salts thereof, solvates of any of the foregoing, and deuterated derivatives of any of the foregoing, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease.