公开(公告)号：AU2007297754B2

公开(公告)日：2012-05-17

申请号：AU2007297754

申请日：2007-09-18

Applicant: VERTEX PHARMA

Inventor： MCGINTY KIRA ,  NANTHAKUMAR SUGANTHINI ,  COURT JOHN ,  STAMOS DEAN ,  TANNER KIRK ,  LI PAN ,  ARONOV ALEXANDER ,  COME JON ,  LAUFFER DAVID ,  DEININGER DAVID

IPC: C07D497/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04

Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.

公开(公告)号：CA2663528A1

公开(公告)日：2008-03-27

申请号：CA2663528

申请日：2007-09-18

Applicant: VERTEX PHARMA

Inventor： TANNER KIRK ,  NANTHAKUMAR SUGANTHINI ,  COME JON ,  ARONOV ALEXANDER ,  MCGINTY KIRA ,  LI PAN ,  COURT JOHN ,  DEININGER DAVID ,  STAMOS DEAN ,  LAUFFER DAVID

IPC: C07D497/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04

Abstract: The present invention provides compounds useful as inhibitors of c-Met ty rosine kinase. The invention also provides pharmaceutically acceptable compo sitions comprising the compounds of the invention and methods of using the c ompositions in the treatment of various proliferative disorders.

公开(公告)号：AU2007297754A1

公开(公告)日：2008-03-27

申请号：AU2007297754

申请日：2007-09-18

Applicant: VERTEX PHARMA

Inventor： MCGINTY KIRA ,  NANTHAKUMAR SUGANTHINI ,  COURT JOHN ,  STAMOS DEAN ,  TANNER KIRK ,  LI PAN ,  ARONOV ALEXANDER ,  COME JON ,  LAUFFER DAVID ,  DEININGER DAVID

IPC: C07D497/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04

Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.

公开(公告)号：NZ575548A

公开(公告)日：2011-09-30

申请号：NZ57554807

申请日：2007-09-18

Applicant: VERTEX PHARMA

Inventor： ARONOV ALEXANDER ,  COME JON ,  COURT JOHN ,  DEININGER DAVID ,  LAUFFER DAVID ,  LI PAN ,  MCGINTY KIRA ,  NANTHAKUMAR SUGANTHINI ,  STAMOS DEAN ,  TANNER KIRK

IPC: C07D497/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04

Abstract: Disclosed is a 5-mercapto-4-amino-4H-1,2,4-triazol-3-yl)ethylcarbamate of formula (I) or a salt, prodrug thereof, wherein LA, Y1 or Y2, Z, R1, R2, R3 and X is defined in the specification for treating colon cancer, gastric adenocarcinoma, bladder cancer, breast cancer, kidney cancer, liver cancer, lung cancer, thyroid cancer, cancer of the head and neck, prostate cancer, pancreatic cancer, cancer of the CNS, gliobastoma, or atherosclerosis.

公开(公告)号：MX2009002842A

公开(公告)日：2009-05-27

申请号：MX2009002842

申请日：2007-09-18

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  STAMOS DEAN ,  ARONOV ALEXANDER ,  LI PAN ,  MCGINTY KIRA ,  COME JON ,  COURT JOHN ,  DEININGER DAVID ,  NANTHAKUMAR SUGANTHINI ,  TANNER KIRK

IPC: C07D497/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04

Abstract: La presente invención provee compuestos de utilidad as inhibidores tirosina quinasa c-Met. La invención también provee composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos para usar las composiciones en el tratamiento de diversos trastornos proliferativos.