公开(公告)号：WO2008116139A3

公开(公告)日：2008-12-18

申请号：PCT/US2008057797

申请日：2008-03-21

Applicant: VERTEX PHARMA ,  WANNAMAKER MARION ,  SALITURO FRANCESCO ,  PIERCE ALBERT ,  ARONOV ALEXANDER ,  MARTINEZ-BOTELLA GABRIEL ,  WANG JIAN ,  FARMER LUC ,  LEDEBOER MARK ,  WANG TIANSHENG ,  BETHIEL RANDY ,  LEDFORD BRIAN ,  PORTER EMILIE

Inventor： WANNAMAKER MARION ,  SALITURO FRANCESCO ,  PIERCE ALBERT ,  ARONOV ALEXANDER ,  MARTINEZ-BOTELLA GABRIEL ,  WANG JIAN ,  FARMER LUC ,  LEDEBOER MARK ,  WANG TIANSHENG ,  BETHIEL RANDY ,  LEDFORD BRIAN ,  PORTER EMILIE

IPC: C07D213/74 ,  A61K31/506 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D401/14 ,  C07D213/74 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

公开(公告)号：WO2007041130A3

公开(公告)日：2010-01-21

申请号：PCT/US2006037593

申请日：2006-09-28

Applicant: VERTEX PHARMA ,  SALITURO FRANCESCO ,  FARMER LUC ,  WANG TIANSHENG ,  WANG JIAN ,  BETHIEL RANDY ,  WANNAMAKER MARION ,  MARTINEZ-BOTELLA GABRIEL ,  DUFFY JOHN ,  ARONOV ALEXANDER ,  LAUFFER DAVID ,  PIERCE ALBERT

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  WANG TIANSHENG ,  WANG JIAN ,  BETHIEL RANDY ,  WANNAMAKER MARION ,  MARTINEZ-BOTELLA GABRIEL ,  DUFFY JOHN ,  ARONOV ALEXANDER ,  LAUFFER DAVID ,  PIERCE ALBERT

IPC: C07D487/04 ,  A61K31/495 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D519/00

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及用作蛋白激酶抑制剂，特别是JAK家族激酶的抑制剂的式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

公开(公告)号：WO2007111904A3

公开(公告)日：2007-12-13

申请号：PCT/US2007007016

申请日：2007-03-21

Applicant: VERTEX PHARMA ,  LAUFFER DAVID J ,  DAVIES ROBERT J ,  STAMOS DEAN ,  ARONOV ALEXANDER ,  DEININGER DAVID D ,  GREY RONALD JR ,  XU JINWANG ,  LI PAN ,  LEDFORD BRIAN ,  FARMER LUC ,  BETHIEL RANDY SCOTT ,  JACOBS DYLAN ,  MCGINTY KIRA

Inventor： LAUFFER DAVID J ,  DAVIES ROBERT J ,  STAMOS DEAN ,  ARONOV ALEXANDER ,  DEININGER DAVID D ,  GREY RONALD JR ,  XU JINWANG ,  LI PAN ,  LEDFORD BRIAN ,  FARMER LUC ,  BETHIEL RANDY SCOTT ,  JACOBS DYLAN ,  MCGINTY KIRA

IPC: C07D401/04 ,  A61K31/4439 ,  A61K31/497 ,  A61K35/00 ,  A61P35/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/04

CPC classification number: C07D417/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D407/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D495/04 ,  C07D498/08 ,  C07D513/04 ,  C12N9/99

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。

公开(公告)号：WO2007064797A3

公开(公告)日：2007-12-13

申请号：PCT/US2006045847

申请日：2006-11-30

Applicant: VERTEX PHARMA ,  LAUFFER DAVID ,  ARONOV ALEXANDER ,  LI PAN ,  DEININGER DAVID ,  MCGINTY KIRA ,  STAMOS DEAN ,  COME JON ,  STEWART MICHELLE

Inventor： LAUFFER DAVID ,  ARONOV ALEXANDER ,  LI PAN ,  DEININGER DAVID ,  MCGINTY KIRA ,  STAMOS DEAN ,  COME JON ,  STEWART MICHELLE

IPC: C07D487/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D498/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.

Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。

公开(公告)号：EP3250562A4

公开(公告)日：2018-07-11

申请号：EP16744240

申请日：2016-01-29

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA ,  ALARGOVA ROSSITZA GUEORGUIEVA

IPC: C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

CPC classification number: C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：NZ772411A

公开(公告)日：2022-05-27

申请号：NZ77241116

申请日：2016-01-29

Applicant: VERTEX PHARMA ,  BIOMED VALLEY DISCOVERIES INC

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA ,  ALARGOVA ROSSITZA GUEORGUIEVA

IPC: C07D401/04

Abstract: The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：AU2016211246A1

公开(公告)日：2017-08-10

申请号：AU2016211246

申请日：2016-01-29

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA ,  ALARGOVA ROSSITZA GUEORGUIEVA

IPC: C07D401/04

Abstract: The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer. It has been discovered that crystalline forms of 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1 H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyl]amide can be prepared which exhibit improved properties, e.g. surprisingly improved stability and improved solubility characteristics. Thus, the present invention provides crystalline 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyljamide.

公开(公告)号：ES2401192T8

公开(公告)日：2013-05-10

申请号：ES06815526

申请日：2006-09-28

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  WANG TIANSHENG ,  WANG JIAN ,  BETHIEL RANDY ,  WANNAMAKER MARION ,  MARTINEZ-BOTELLA GABRIEL ,  DUFFY JOHN ,  ARONOV ALEXANDER ,  LAUFFER DAVID ,  PIERCE ALBERT

IPC: C07D487/04 ,  A61K31/495 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D519/00

公开(公告)号：NZ588700A

公开(公告)日：2012-07-27

申请号：NZ58870009

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  ARONOV ALEXANDER ,  CORNEBISE MARK ,  MALTAIS FRANCOIS ,  LEDOBOER MARK ,  LE TIRAN ARNAUD ,  MARONE VALERIE ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  COME JON H

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: Provided are inhibitors of phosphatidylinositol 3-kinases with formula (I) as depicted, with defined substituents. The compounds are useful for lessening the severity of a disease or condition selected from an autoimmune disease or an inflammatory disease of the brain or spinal cord.

公开(公告)号：AU2007297754B2

公开(公告)日：2012-05-17

申请号：AU2007297754

申请日：2007-09-18

Applicant: VERTEX PHARMA

Inventor： MCGINTY KIRA ,  NANTHAKUMAR SUGANTHINI ,  COURT JOHN ,  STAMOS DEAN ,  TANNER KIRK ,  LI PAN ,  ARONOV ALEXANDER ,  COME JON ,  LAUFFER DAVID ,  DEININGER DAVID

IPC: C07D497/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04

Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.