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公开(公告)号：WO2018158730A1
公开(公告)日：2018-09-07
申请号：PCT/IB2018/051324
申请日：2018-03-01
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , JARRELL, Joseph A. , MICHIENZI, Joseph D. , MCDONALD, Thomas S.
CPC classification number: G01N30/32 , B01D15/163 , B01D15/40 , G01N30/34 , G01N30/36 , G01N30/62 , G01N30/7233 , G01N2030/326 , G01N2030/347 , G01N2030/623
Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO 2 -based chromatography system. A first CO 2 pump operates in constant flow mode and delivers CO 2 to a chromatography column, and liquid modifier is introduced to the chromatography column according to a gradient. A second CO 2 pump is disposed downstream of the column and operates in constant pressure mode to introduce CO 2 into a flow stream at an output of the column. Liquid modifier is also introduced into the flow stream at the output of the column according to a reverse gradient compared to the gradient entering the chromatography column.
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公开(公告)号：WO2019229673A1
公开(公告)日：2019-12-05
申请号：PCT/IB2019/054452
申请日：2019-05-29
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , MCDONALD, Thomas S. , SHREVE, Joshua A.
Abstract: The present disclosure relates to methodologies, systems, apparatus, and kits for controlling fluid flow within a chromatography system. A makeup pump is configured to pump a makeup fluid into the chromatography system downstream of the column. A first restrictor is located upstream of a detector and downstream of both the makeup pump and the column. Decreasing an output volume of the makeup pump can direct an output from the column through the first restrictor to the detector. Increasing an output volume of the makeup pump can direct the output from the column to a second restrictor located downstream of the makeup pump and the column and in parallel with the first restrictor and the detector.
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公开(公告)号：WO2019224702A3
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054162
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
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4.发明申请
公开(公告)号：WO2019224701A1
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054161
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.
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5.发明申请
公开(公告)号：WO2019186469A1
公开(公告)日：2019-10-03
申请号：PCT/IB2019/052566
申请日：2019-03-28
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GRITTI, Fabrice , MCDONALD, Thomas S. , LEAL, Mike
Abstract: The technology relates to a recycling chromatography method. A sampled is injected into a mobile phase flow stream of a liquid chromatography system creating a combined flow stream. The liquid chromatography system includes at least two columns positioned in series, a valve in fluid communication with the at least two columns, and a detection cell positioned between the at least two columns. The combined flow stream is flowed through the at least two columns and chromatographic peaks of the sample are monitored by the detection cell. The detection cell is configured to measure resolution and width of the chromatographic peaks and automatically switch the valve from a first position to a second position when the measured resolution is less than a desired resolution, the measured width is less than a maximum combined peak width, and a switch count is less than a predetermined maximum number of switches.
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Patent Agency Ranking
公开(公告)号：WO2022079645A1
公开(公告)日：2022-04-21
申请号：PCT/IB2021/059426
申请日：2021-10-13
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： MCDONALD, Thomas S. , WYNDHAM, Kevin , VISSERS, Johannes
IPC: G01N33/569 , G01N33/68
Abstract: The present disclosure relates to methods and workflows for processing and analyzing clinical samples (e.g., nasal swabs, throat swabs, plasma samples, urine, etc.) In general, the methods and workflows involve the detection of an infectious state and are improved over contemporary methods due to increased throughput with improved resolution of positive results.
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公开(公告)号：WO2019224702A2
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054162
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Sample preparation and separation can be performed using a sample cartridge. The cartridge incudes a barrel with a first and second end, a column segment connected to the second end of the barrel, and a column containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
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8.发明申请
公开(公告)号：WO2018158731A1
公开(公告)日：2018-09-07
申请号：PCT/IB2018/051325
申请日：2018-03-01
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , SHREVE, Joshua A. , EGGERTSON, Michael , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , TARAFDER, Abhijit
CPC classification number: G01N30/32 , B01D15/163 , B01D15/40 , G01N30/34 , G01N30/7233 , G01N2030/326
Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO 2 -based chromatography system. A first pressure control element is located downstream of a CO 2 -based chromatography system and is disposed to control pressure within the column. A split restrictor is located downstream of the primary pressure control element and is disposed to divert a portion of the mobile phase flow to a detector. A second pressure control element is located downstream of the split restrictor and is disposed to control pressure at the restrictor. While the first pressure control element executes a pressure-controlled gradient separation, the second pressure control element maintains a constant pressure at the restrictor. During a composition-programmed gradient separation, the second control element maintains a constant pressure at the split restrictor while the first pressure control element maintains a constant average density across the column.
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9.发明公开
公开(公告)号：EP3773968A1
公开(公告)日：2021-02-17
申请号：EP19724232.4
申请日：2019-03-28
Applicant: Waters Technologies Corporation
Inventor： GRITTI, Fabrice , MCDONALD, Thomas S. , LEAL, Mike
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公开(公告)号：EP3797291A2
公开(公告)日：2021-03-31
申请号：EP19744841.8
申请日：2019-05-20
Applicant: Waters Technologies Corporation
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