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    LOW BINDING SURFACES FOR PEPTIDE MAPPING
    1.
    发明申请
    LOW BINDING SURFACES FOR PEPTIDE MAPPING 审中-公开

    公开(公告)号：WO2021144765A1

    公开(公告)日：2021-07-22

    申请号：PCT/IB2021/050318

    申请日：2021-01-16

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： BIRDSALL, Robert ,  KELLETT, Jacob ,  RANBADUGE, Nilini ,  YU, Ying Qing ,  NGUYEN, Jennifer M. ,  LAUBER, Matthew A.

    IPC: G01N30/56 ,  G01N2030/567 ,  G01N2030/8831

    Abstract: The present disclosure discusses a method of separating a sample (e.g., peptide compound) including coating a flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample – and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating (e.g., organosilica coating) of the flow path. The applied coating can reduce peak tailing and increase analyte recovery for the sample of the chromatographic system.

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