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    一种共光路干涉相位显微一次成像系统及方法
    1.
    发明公开
    一种共光路干涉相位显微一次成像系统及方法 失效

    公开(公告)号：CN106770288A

    公开(公告)日：2017-05-31

    申请号：CN201611129999.5

    申请日：2016-12-09

    Applicant: 江苏大学

    Inventor： 季颖 ,  张明明 ,  王亚伟

    IPC: G01N21/84 ,  G01J9/02

    CPC classification number: G01N21/84 ,  G01J9/02 ,  G01J2009/0223 ,  G01J2009/0234 ,  G01J2009/0269 ,  G01N2201/06113

    Abstract: 本发明提供一种共光路干涉相位显微一次成像系统及方法，包括激光器、中性可调衰减器、扩束准直器、半透半反镜、视场光阑、非偏振分光棱镜、反射载物台、样品、显微物镜、第三透镜、CCD和计算机；本发明基于差分干涉光路，采用非偏振分光镜把激光分为物光与参考光两束平行光，再利用反射载物台全反射物光与参考光，物光和参考光经非偏振分光棱镜合束后以共光路的方式传播，后经显微物镜放大，最终被CCD相机采集并传输到计算机里并显示；本发明可通过调整反射载物台的角度实现现有的光路干涉成像系统，其中包括离轴干涉、同轴干涉和轻微离轴干涉。本发明在相位显微方面具有广泛的实用价值与应用前景，特别是在生物细胞形态识别应用领域。

    Conformal imaging vibrometer using adaptive optics with scene-based wave-front sensing
    3.
    发明公开
    Conformal imaging vibrometer using adaptive optics with scene-based wave-front sensing 审中-公开

    公开(公告)号：US20230175893A1

    公开(公告)日：2023-06-08

    申请号：US17544877

    申请日：2021-12-08

    Applicant: David Mort Pepper

    Inventor： David Mort Pepper

    IPC: G01J9/04 ,  G01J9/02

    CPC classification number: G01J9/04 ,  G01J9/02 ,  G01J2009/0249 ,  G01J2009/0269

    Abstract: Conformal imaging vibrometer using adaptive optics with scene-based wave front sensing. An extended object is located at the first end of a link, and a reference-free, adaptive optical, conformal imaging vibrometer using scene-based wave front sensing is located at the second end of the link. An aberrated, free space or guided-wave path exists between the ends of the link. The adaptive optical system compensates for path distortions. Using a single interrogation beam, whole-body vibrations of opaque and reflective objects can be probed, as well as transparent and translucent objects, the latter pair employing a Zernike heterodyne interferometer.

    Apparatus and method for performing two-frequency interferometry
    4.
    发明授权
    Apparatus and method for performing two-frequency interferometry 失效
    用于执行双频干涉测量的装置和方法

    公开(公告)号：US4906095A

    公开(公告)日：1990-03-06

    申请号：US147468

    申请日：1988-01-25

    Applicant: Roger G. Johnston

    Inventor： Roger G. Johnston

    IPC: G01J9/02 ,  G01N21/17 ,  G01N21/19

    CPC classification number: G01J9/02 ,  G01N21/171 ,  G01J2009/0207 ,  G01J2009/0261 ,  G01J2009/0269 ,  G01N21/19

    Abstract: The present apparatus includes a two-frequency, Zeeman-effect laser and matched, doubly refracting crystals in the construction of an accurate interferometer. Unlike other interferometric devices, the subject invention exhibits excellent phase stability owing to the use of single piece means for producing parallel interferometer arms, making the interferometer relatively insensitive to thermal and mechanical instabilities. Interferometers respond to differences in optical path length between their two arms. Unlike many interferometric techniques, which require the measurement of the location of interference fringes in a brightly illuminated background, the present invention permits the determination of the optical path length difference by measuring the phase of an electronic sine wave. The present apparatus is demonstrated as a differential thermooptic spectrometer for measuring differential optical absorption simply and accurately which is but one of many applications therefor. The relative intensities of the heating beams along each arm of the interferometer can be easily adjusted by observing a zero phase difference with identical samples when this condition is obtained.

    Abstract translation: 本设备包括一个双频塞曼效应激光器和匹配的双折射晶体，构建精确的干涉仪。 与其他干涉仪装置不同，本发明由于使用用于产生平行干涉仪臂的单件装置显示出优异的相位稳定性，使得干涉仪对热和机械不稳定性相对不敏感。 干涉仪响应两臂之间光程长度的差异。 与需要在明亮照明背景中测量干涉条纹的位置的许多干涉测量技术不同，本发明允许通过测量电子正弦波的相位来确定光程长度差异。 本装置被证明是用于简单且精确地测量差分光吸收的差分热光谱仪，其仅是许多应用之一。 当获得该条件时，可以通过观察相同样品的零相位差来容易地调节沿着干涉仪的每个臂的加热束的相对强度。

    SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY
    6.
    发明申请
    SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY 审中-公开
    空域低相位定量相位显微镜

    公开(公告)号：US20150204728A1

    公开(公告)日：2015-07-23

    申请号：US14562092

    申请日：2014-12-05

    Applicant: Yang Liu ,  Randall E. Brand ,  Hoa V. Pham ,  Shikhar Fnu

    Inventor： Yang Liu ,  Randall E. Brand ,  Hoa V. Pham ,  Shikhar Fnu

    IPC: G01J9/02

    CPC classification number: G01J9/02 ,  G01J2009/0223 ,  G01J2009/0253 ,  G01J2009/0269 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1475 ,  G01N2015/1402 ,  G01N2015/1479 ,  G02B21/14 ,  G02B21/365

    Abstract: Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. Techniques that provide for depth selective investigation of nuclear and other cellular features are disclosed.

    Abstract translation: 本文描述了与空间域低相干定量相位显微镜（SL-QPM）相关联的系统，方法和其它实施例。 SL-QPM可以检测细胞核内的结构变化，具有纳米级灵敏度（0.9 nm）（或核纳米形态），用于癌症的“纳米病理诊断”。 SL-QPM使用原始，未修改的细胞学和组织学标本，用标准临床方案和污渍制备。 SL-QPM可以轻松整合到现有的临床病理实验室。 结果量化了具有纳米尺度敏感性的单个核中光程长度或折射率的空间分布，可用于研究核纳米形态作为癌症进展。 来自SL-QPM的核纳米形态为临床护理和亚细胞机械学基础和翻译研究提供了显着的诊断价值。 公开了提供对核和其他蜂窝特征的深度选择性研究的技术。

    SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY
    9.
    发明申请
    SPATIAL-DOMAIN LOW-COHERENCE QUANTITATIVE PHASE MICROSCOPY 审中-公开
    空域低相位定量相位显微镜

    公开(公告)号：WO2015085216A1

    公开(公告)日：2015-06-11

    申请号：PCT/US2014/068869

    申请日：2014-12-05

    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  LIU, Yang ,  BRAND, Randall E. ,  PHAM, Hoa V. ,  FNU, Shikhar

    Inventor： LIU, Yang ,  BRAND, Randall E. ,  PHAM, Hoa V. ,  FNU, Shikhar

    IPC: G02B21/14 ,  G02B26/06 ,  G01N21/17 ,  G01J9/02 ,  G02F1/33

    CPC classification number: G01J9/02 ,  G01J2009/0223 ,  G01J2009/0253 ,  G01J2009/0269 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1475 ,  G01N2015/1402 ,  G01N2015/1479 ,  G02B21/14 ,  G02B21/365

    Abstract: Systems, methods and other embodiments associated with spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM) are described herein. SL-QPM can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for "nano-pathological diagnosis" of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses. The nuclear nano-morphology derived from SL-QPM offers significant diagnostic value in clinical care and subcellular mechanistic insights for basic and translational research. Techniques that provide for depth selective investigation of nuclear and other cellular features are disclosed.

    Abstract translation: 本文描述了与空间域低相干定量相位显微术（SL-QPM）相关联的系统，方法和其它实施例。 SL-QPM可以检测细胞核内的结构变化，具有纳米级灵敏度（0.9nm）（或核纳米形态）用于癌症的“纳米病理诊断”。 SL-QPM使用原始，未修改的细胞学和组织学标本，用标准临床方案和污渍制备。 SL-QPM可以轻松整合到现有的临床病理实验室。 结果量化了具有纳米级灵敏度的单个核中光程长度或折射率的空间分布，可用于研究核纳米形态作为癌症进展。 来自SL-QPM的核纳米形态为临床护理和亚细胞机械学基础和翻译研究提供了显着的诊断价值。 公开了提供对核和其他蜂窝特征的深度选择性研究的技术。

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