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    Two-phase technique to restore artery patency and a catheter temperature control system in atherectomy
    1.
    发明授权
    Two-phase technique to restore artery patency and a catheter temperature control system in atherectomy 有权

    公开(公告)号：US10945757B2

    公开(公告)日：2021-03-16

    申请号：US16342573

    申请日：2017-10-17

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Hitinder S. Gurm ,  Yao Liu ,  Yang Liu ,  Yihao Zheng ,  Albert Shih

    IPC: A61B17/3207 ,  A61B17/00 ,  A61B17/32

    Abstract: A method of two-phase atherectomy for removal of plaque within an artery forming a stenosis including a first phase of rotational drilling by exerting a rotational force on a cutter to form a channel within the plaque having a diameter substantially equal to a diameter of the cutter—the cutter being rotated at a first rotational speed sufficient to maintain rotation of the cutter about a stationary rotational axis—and a second phase of orbital impact by exerting a rotational force on the cutter to result in radial orbital motion of the cutter within the channel resulting in periodic impact of the cutter upon the plaque to form micro-fractures within the plaque and enlarge the diameter of the channel to a diameter substantially greater than the diameter of the cutter—the cutter being rotated at a second rotational speed to result in the radial orbital motion of the cutter.

    Histotripsy for thrombolysis
    2.
    发明授权
    Histotripsy for thrombolysis 有权

    公开(公告)号：US12150661B2

    公开(公告)日：2024-11-26

    申请号：US18329459

    申请日：2023-06-05

    Applicant: The Regents of the University of Michigan

    Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

    IPC: A61B17/22 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B17/225 ,  A61B90/00 ,  A61M37/00

    Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

    Histotripsy therapy systems and methods for the treatment of brain tissue
    4.
    发明授权
    Histotripsy therapy systems and methods for the treatment of brain tissue 有权

    公开(公告)号：US12220602B2

    公开(公告)日：2025-02-11

    申请号：US17407780

    申请日：2021-08-20

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Zhen Xu ,  Jonathan Sukovich ,  Aditya S. Pandey ,  Charles A. Cain ,  Hitinder S. Gurm

    IPC: A61N7/00 ,  A61N7/02

    Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

    Histotripsy for thrombolysis
    5.
    发明授权
    Histotripsy for thrombolysis 有权

    公开(公告)号：US11364042B2

    公开(公告)日：2022-06-21

    申请号：US16293394

    申请日：2019-03-05

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

    IPC: A61B17/22 ,  A61B17/225 ,  A61M37/00 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B90/00

    Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

    Histotripsy therapy systems and methods for the treatment of brain tissue
    6.
    发明授权
    Histotripsy therapy systems and methods for the treatment of brain tissue 有权

    公开(公告)号：US11135454B2

    公开(公告)日：2021-10-05

    申请号：US15737761

    申请日：2016-06-23

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Zhen Xu ,  Jonathan Sukovich ,  Aditya S. Pandey ,  Charles A. Cain ,  Hitinder S. Gurm

    IPC: A61N7/02 ,  A61N7/00

    Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

    System for effecting and controlling oscillatory pressure within balloon catheters for fatigue fracture of calculi
    10.
    发明授权
    System for effecting and controlling oscillatory pressure within balloon catheters for fatigue fracture of calculi 有权

    公开(公告)号：US11464949B2

    公开(公告)日：2022-10-11

    申请号：US16654073

    申请日：2019-10-16

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Robert Chisena ,  Hitinder S. Gurm ,  Matthew Hildner ,  Yihao Zheng ,  Albert Shih

    IPC: A61M25/10 ,  A61B17/22 ,  A61B17/00

    Abstract: A dynamic balloon angioplasty system for applying a dynamic pressure to fracture hardened materials embedded within an elastic conduit. The system having a pressure source system outputting at least a first predetermined pressure from a pressure source outlet, and an angioplasty unit fluidly coupled to the pressure source outlet receiving at least the first predetermined pressure. The angioplasty unit having an angioplasty inflation device, an angioplasty balloon connector, and an oscillating mechanism selectively actuated to output a plurality of pressure pulses to the angioplasty balloon via a fluid communication path. A control system is configured to determine an optimal hydraulic pressure oscillation frequency and amplitude for a given procedure and output a control signal to the oscillating mechanism, and monitor a pressure signal to detect fracture of the hardened material within the elastic conduit or system failure or leakage.

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