公开(公告)号：US20160124059A1

公开(公告)日：2016-05-05

申请号：US14932539

申请日：2015-11-04

Applicant: Colorado State University Research Foundation ,  The General Hospital Corporation

Inventor： Branislav M. Notaros ,  Milan M. Ilic ,  Alexey A. Tonyushkin ,  Nada J. Sekeljic ,  Pranav S. Athalye

IPC: G01R33/34

Abstract: Example devices and methods of MRI scanning are disclosed herein. In an example, an MRI scanning system may include a structure defining a bore within which a subject is to be positioned for scanning. The system may also include a magnet to generate a primary magnetic field within the bore parallel to a longitudinal axis of the bore, and a helical-antenna radio-frequency (RF) coil oriented along the longitudinal axis to surround the subject. In addition, the system may include an RF signal generator to drive the helical-antenna RF coil to generate a circularly polarized (CP) RF magnetic field perpendicular to the longitudinal axis, as well as an RF detector to detect a response signal generated by tissues of the subject in response to the CP RF magnetic field. Also included may be a computing system to create an image of the tissues of the subject based on the detected response signal.

Abstract translation: 本文公开了MRI扫描的示例性装置和方法。 在一个示例中，MRI扫描系统可以包括限定要在其中定位被摄体用于扫描的孔的结构。 该系统还可以包括磁体，以在平行于孔的纵向轴线的孔内产生初级磁场，以及螺旋天线射频（RF）线圈，其沿着纵向轴线定向以包围对象。 此外，系统可以包括RF信号发生器，以驱动螺旋天线RF线圈以产生垂直于纵轴的圆偏振（CP）RF磁场，以及RF检测器，用于检测组织产生的响应信号 的受试者响应于CP RF磁场。 还包括可以是基于检测到的响应信号来创建对象的组织的图像的计算系统。

公开(公告)号：US09305733B2

公开(公告)日：2016-04-05

申请号：US14263970

申请日：2014-04-28

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Lauren P. Rand ,  John D. Williams ,  Rafael A. Martinez

IPC: H01J1/14 ,  H01J27/14 ,  H01J1/02 ,  H01J27/08

CPC classification number: H01J1/025 ,  F03H1/0068 ,  H01J1/14 ,  H01J27/08 ,  H01J27/146 ,  H01J2237/08

Abstract: The use of the electride form of 12CaO-7Al2O3, or C12A7, as a low work function electron emitter in a hollow cathode discharge apparatus is described. No heater is required to initiate operation of the present cathode, as is necessary for traditional hollow cathode devices. Because C12A7 has a fully oxidized lattice structure, exposure to oxygen does not degrade the electride. The electride was surrounded by a graphite liner since it was found that the C12A7 electride converts to it's eutectic (CA+C3A) form when heated (through natural hollow cathode operation) in a metal tube.

Abstract translation: 描述了在空心阴极放电装置中使用12CaO-7Al2O3或C12A7的电子形式作为低功函电子发射体。 根据传统的空心阴极器件的需要，不需要加热器来启动本阴极的操作。 因为C12A7具有完全氧化的晶格结构，所以暴露于氧气不会降低电极。 电极被石墨衬垫包围，因为发现当在金属管中加热（通过天然空心阴极操作）时，C12A7电致转变成它的共晶（CA + C3A）形式。

公开(公告)号：US20160075576A1

公开(公告)日：2016-03-17

申请号：US14485631

申请日：2014-09-12

Applicant: Colorado State University Research Foundation ,  Chevron Corporation

Inventor： Julio A. Zimbron ,  Thomas C. Sale ,  Matthew J. Biondolillo ,  Philip H. Batten ,  Marc Chalfant ,  Mark Lyverse

IPC: C02F3/02

CPC classification number: C02F3/02 ,  C02F2101/32 ,  C02F2103/06 ,  Y02W10/15

Abstract: A method for controlling petroleum hydrocarbon (NAPL) sheen releases resulting from seeps, ebullition and erosion, on water surfaces, is described. An oleophilic bio-Barrier (OBBs), which may include a composite of hydrocarbon sorptive materials through which water is readily conducted, is placed at a groundwater/surface water interface (GSI) for promoting natural aerobic degradation of the intercepted/adsorbed NAPL through natural cycling of aerobic surface water and/or atmospheric oxygen. OBBs may be protected by structural covers (i.e., sand and rock gabions, as examples).

Abstract translation: 描述了一种在水面上控制由渗漏，沸腾和侵蚀引起的石油烃（NAPL）光泽释放的方法。 亲水生物屏障（OBBs）可以包括通过其容易地进行水的碳氢化合物吸附材料的复合物置于地下水/表面水界面（GSI），以通过自然来促进截留/吸附的NAPL的自然需氧降解 有氧表面水和/或大气氧的循环。 OBB可以由结构覆盖物（例如，砂岩和岩石石笼，例如）来保护。

公开(公告)号：US09255924B2

公开(公告)日：2016-02-09

申请号：US14052378

申请日：2013-10-11

Applicant: University of Notre Dame du Lac ,  Colorado State University Research Foundation

Inventor： Jeffrey S. Schorey ,  Karen M. Dobos

IPC: A61K39/04 ,  C12N1/20 ,  G01N33/569 ,  G01N33/68 ,  C07K14/35

CPC classification number: G01N33/5695 ,  A61K39/04 ,  C07K14/35 ,  G01N33/6848 ,  G01N2333/35

Abstract: The invention provides methods for the detection of M. tuberculosis proteins in or on exosomes derived from infected individuals. The methods can use a proteomic approach including mass spectroscopy, data mining and multiplex reaction monitoring to quickly examine a large amount of M. tuberculosis proteins to determine the best biomarkers for use in diagnostic tests to identify active TB patients.

Abstract translation: 本发明提供了用于检测衍生自感染个体的外​​来体中或其外的结核分枝杆菌蛋白质的方法。 这些方法可以使用蛋白质组学方法，包括质谱，数据挖掘和多重反应监测，以快速检查大量结核分枝杆菌蛋白，以确定用于诊断测试以鉴定活动性TB患者的最佳生物标志物。

公开(公告)号：US09176059B2

公开(公告)日：2015-11-03

申请号：US13712425

申请日：2012-12-12

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  David S. Dandy ,  Matthew D. Stephens ,  Guangwei Yuan

IPC: G01N21/00 ,  G01N21/552 ,  G01N33/543

CPC classification number: G01N21/552 ,  G01N21/41 ,  G01N33/54373 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.

Abstract translation: 描述了能够直接，实时地检测和监测波导表面附近的分析物而不需要分析物的标记或标记的波导传感器。 分析和数值计算已经预测，由于分析物的存在，通过局部检测ev逝场的变化或耦合在波导外的光的变化，将能够实现高检测灵敏度。

公开(公告)号：US20150299890A1

公开(公告)日：2015-10-22

申请号：US14600386

申请日：2015-01-20

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Derek C. Johnson ,  Amy L. Prieto

IPC: C25D13/02 ,  G01N27/416 ,  C23C18/16 ,  G01N27/30

CPC classification number: C25D13/02 ,  C23C18/1683 ,  C25D3/58 ,  G01N27/302 ,  G01N27/4167 ,  G01N31/164 ,  H01M2/1673 ,  H01M4/045 ,  H01M4/0452 ,  H01M4/1395 ,  H01M4/366 ,  H01M10/052 ,  H01M10/0562 ,  Y02E60/122

Abstract: An apparatus and method for measuring the isoelectric pH for materials deposited on or otherwise affixed onto and in contact with an electrode surface, and a method for utilizing the isoelectric pH to form nanometer thickness, self-assembled layers on the material, are described. Forming such layers utilizing information obtained about the isoelectric pH values of the substrate and the coating is advantageous since the growth of the coating is self-limiting because once the surface charge has been neutralized there is no longer a driving force for the solid electrolyte coating thickness to increase, and uniform coatings without pinhole defects will be produced because a local driving force for assembly will exist if any bare electrode material is exposed to the solution. The present self-assembly procedure, when combined with electrodeposition, may be used to increase the coating thickness. Self-assembly, with or without additional electrodeposition, allows intimate contact between the anode, electrolyte and cathode which is required for successful application to solid-state batteries, as an example.

Abstract translation: 描述了用于测量沉积在电极表面上或与电极表面接触或接触电极表面的材料的等电位pH的装置和方法，以及用于在该材料上形成纳米厚度的自组装层的等电位pH的方法。 利用关于基材和涂层的等电位pH值获得的信息形成这样的层是有利的，因为涂层的生长是自限制性的，因为一旦表面电荷被中和，就不再有固体电解质涂层厚度的驱动力 增加，并且将产生没有针孔缺陷的均匀涂层，因为如果任何裸电极材料暴露于溶液，则将存在组装的局部驱动力。 现在的自组装程序，当与电沉积结合时，可以用于增加涂层厚度。 作为示例，具有或不具有附加电沉积的自组装允许成功应用于固态电池所需的阳极，电解质和阴极之间的紧密接触。

公开(公告)号：US20150221229A1

公开(公告)日：2015-08-06

申请号：US14611072

申请日：2015-01-30

Applicant: Colorado State University Research Foundation

Inventor： Joseph P. Cannon ,  Brian Fugate

IPC: G09B7/04

CPC classification number: G09B7/04

Abstract: A method includes presenting to an online learner a first question. The method also includes receiving a first answer of the online learner to the first question. The method also includes presenting to the online learner a second question that requests a justification for the first answer. The method also includes receiving a second answer of the online learner to the second question. The method also includes storing, in a learner account of the online learner, the second answer in association with the first answer. The method also includes finding a different second answer of a different online learner and which is associated with a different first answer of the different online learner. The method also includes presenting the different second answer to the online learner.

Abstract translation: 一种方法包括向在线学习者呈现第一个问题。 该方法还包括接收第一个问题的在线学习者的第一个答案。 该方法还包括向在线学习者呈现第二个问题，要求为第一个答案提供理由。 该方法还包括接收第二个问题的在线学习者的第二个答案。 该方法还包括在第一个答案中存储在线学习者的学习者帐户中的第二个答案。 该方法还包括找到不同的在线学习者的不同的第二个答案，并且与不同的在线学习者的不同的第一个答案相关联。 该方法还包括向在线学习者呈现不同的第二个答案。

公开(公告)号：US20150105825A1

公开(公告)日：2015-04-16

申请号：US14577906

申请日：2014-12-19

Applicant: Colorado State University Research Foundation

Inventor： Christian M. Puttlitz ,  Benjamin C. Gadomski

IPC: A61B17/70

CPC classification number: A61B17/7038 ,  A61B17/7032 ,  A61B17/7055 ,  A61B17/7067 ,  A61B17/7071

Abstract: An interspinous spacer device for the treatment of high-grade spinal disorders is disclosed herein. The interspinous spacer device includes a sliding rod and a base that contains a curved internal track that limits the range of motion and center of rotation of the spinal segments stabilized using the device to the physiological levels of a nondegraded spinal segment.

Abstract translation: 本文公开了一种用于治疗高级脊柱疾病的椎间间隔装置。 棘突间间隔装置包括滑动杆和基部，其包含弯曲的内部轨道，其将使用该装置稳定的脊柱段的运动范围和旋转中心限制到非降解的脊髓节段的生理水平。

公开(公告)号：US09007562B2

公开(公告)日：2015-04-14

申请号：US13871879

申请日：2013-04-26

Applicant: Colorado State University Research Foundation ,  Synopsys, Inc.

Inventor： Mario C. Marconi ,  Lukasz Urbanski ,  Jorge J. Rocca ,  Artak Isoyan

IPC: G03B27/52 ,  G03F7/20

CPC classification number: B41J2/465 ,  G03F7/2047 ,  G03F7/2053 ,  G03F7/7035 ,  G03F7/70408

Abstract: An apparatus and method for nanopatterning of substrates using the demagnified Talbot effect, wherein: (a) large arrays of nanostructures can rapidly be printed; (b) short extreme ultraviolet wavelengths permits sub-100 nm spatial resolution; (c) the de-magnification factor can be continuously adjusted, that is, continuously scaled; (d) the patterning is the effect of the collective diffraction of numerous tiled units that constitute the periodic array, giving rise to error resistance such that a defect in one unit is averaged over the area of the mask and the print does not show any defects; (e) the Talbot mask does not wear out since the method is non-contact; and (f) the feature sizes on the mask do not have to be as small as the feature sizes desired on the target, are described. The apparatus includes a source of coherent radiation having a chosen wavelength directed onto a focusing optic, the reflected converging light passing through a Talbot mask and impinging on a target substrate.

Abstract translation: 一种用于使用缩小的Talbot效应对基底进行纳米图案化的装置和方法，其中：（a）可以快速地印刷大量纳米结构阵列; （b）短的极紫外波长允许亚100nm的空间分辨率; （c）可以连续地调整去放大系数，即连续缩放; （d）图形化是构成周期性阵列的多个平铺单元的集体衍射的影响，产生误差电阻，使得一个单元中的缺陷在掩模的区域上被平均，并且打印不显示任何缺陷 ; （e）Talbot面膜不会磨损，因为该方法是非接触的; 并且（f）掩模上的特征尺寸不必像目标上所需的特征尺寸一样小。 该装置包括具有指向聚焦光学元件的所选波长的相干辐射源，反射的会聚光穿过Talbot掩模并撞击目标基底。

公开(公告)号：US08956698B2

公开(公告)日：2015-02-17

申请号：US14246935

申请日：2014-04-07

Applicant: Colorado State University Research Foundation

Inventor： Walajabad S. Sampath ,  Pavel S. Kobyakov ,  Kevin E. Walters ,  Davis R. Hemenway

IPC: C23C16/00 ,  C23C16/06 ,  H01L21/00 ,  H01L21/44 ,  H01L21/31 ,  H01L31/18 ,  C23C14/24 ,  C23C16/452

CPC classification number: C23C16/452 ,  C23C14/0629 ,  C23C14/243 ,  H01L21/02422 ,  H01L21/02474 ,  H01L21/02562 ,  H01L21/02631 ,  H01L31/1828 ,  H01L31/1832

Abstract: Systems and methods for depositing complex thin-film alloys on substrates are provided. In particular, systems and methods for the deposition of thin-film Cd1-xMxTe ternary alloys on substrates using a stacked-source sublimation system are provided, where M is a metal such as Mg, Zn, Mn, and Cu.

Abstract translation: 提供了在基片上沉积复合薄膜合金的系统和方法。 特别地，提供了使用堆叠源升华系统在基板上沉积薄膜Cd1-xMxTe三元合金的系统和方法，其中M是诸如Mg，Zn，Mn和Cu的金属。