公开(公告)号：US06454786B1

公开(公告)日：2002-09-24

申请号：US08970291

申请日：1997-11-14

Applicant: Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

Inventor： Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

IPC: A61B1708

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

Abstract: Novel methods and devices which provide enhanced mixing and application of two liquid components to form a biomaterial with minimized aerosols is achieved using air flow rates below about 1.25 liters/minute in combination with a ratio of air flow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the air flow is below about 1 liter/minute and the ratio of air flow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention are novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip or nozzle, novel spray tips and biomaterial applicators and methods for making such applicators.

Abstract translation: 使用低于约1.25升/分钟的空气流速与空气流量与总液体流量的比例为约150:1实现提供两种液体组分的增强混合和应用以形成具有最小化的气溶胶的生物材料的新方法和装置。 1到1500：1。 优选地，气流低于约1升/分钟，并且空气流与总液体流量的比率为约200:1至约1200:1。 这些参数非常适用于喷雾施用形成外科密封剂的组分，例如纤维蛋白封闭剂。 本发明的另一部分是用于生物材料的新型应用方法，例如手术密封剂，液体流速低于1.9ml /分钟的组分，涉及将这些组分混合在喷嘴或喷嘴的出口表面上的新方法，新型喷雾 提示和生物材料施加器以及制造这种涂敷器的方法。

公开(公告)号：US20020113144A1

公开(公告)日：2002-08-22

申请号：US09998794

申请日：2001-12-03

Applicant: Hitachi, Ltd.

Inventor： Min Huang ,  Atsumu Hirabayashi

IPC: B05B007/06

CPC classification number: B05B7/0876 ,  B05B7/066 ,  B05B7/0892 ,  G01N21/714 ,  Y10T436/24

Abstract: Disclosed herein is a nebulizer capable of performing spraying over a wide flow-rate range from a low flow rate to a high flow rate stably and with high efficiency. Further, the present invention provides a supersonic nebulizer capable of improving the efficiency of spraying by a supersonic region spray gas, and a supersonic array nebulizer wherein a plurality of spray units are placed in array form.

公开(公告)号：US06206905B1

公开(公告)日：2001-03-27

申请号：US09358078

申请日：1999-07-21

Applicant: Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

Inventor： Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

IPC: A61B1708

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

Abstract: Novel methods and devices which provide enhanced mixing and application of two liquid components to form a biomaterial with minimized aerosols is achieved using air flow rates below about 1.25 liters/minute in combination with a ratio of air flow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the air flow is below about 1 liter/minute and the ratio of air flow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention are novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip or nozzle, novel spray tips and biomaterial applicators and methods for making such applicators.

Abstract translation: 使用空气流速低于约1.25升/分钟，结合空气流与总液体流量的比例为约150:1，提供增强混合和应用两种液体组分以形成具有最小化气溶胶的生物材料的新方法和装置。 1到1500：1。 优选地，气流低于约1升/分钟，并且空气流与总液体流量的比率为约200:1至约1200:1。 这些参数非常适用于喷雾施用形成外科密封剂的组分，例如纤维蛋白封闭剂。 本发明的另一部分是用于生物材料的新型应用方法，例如手术密封剂，液体流速低于1.9ml /分钟的组分，涉及将这些组分混合在喷嘴或喷嘴的出口表面上的新方法，新型喷雾 提示和生物材料施加器以及制造这种涂敷器的方法。

公开(公告)号：US4891249A

公开(公告)日：1990-01-02

申请号：US198689

申请日：1988-03-24

Applicant: Frederic S. McIntyre

Inventor： Frederic S. McIntyre

IPC: B05D7/24 ,  B05B7/04 ,  B05B7/06 ,  B05B7/08 ,  B05B7/24 ,  B05C5/02 ,  B05D1/02 ,  B05D1/32 ,  B05D1/40 ,  B05D7/00

CPC classification number: B05D1/32 ,  B05B7/0475 ,  B05B7/066 ,  B05B7/0815 ,  B05B7/0846 ,  B05B7/0876 ,  B05B7/2489 ,  B05C5/02 ,  B05C5/025 ,  Y10T156/1089 ,  Y10T156/1095

Abstract: The invention relates to an apparatus and method of controlling the generation of somewhat-to-highly viscous fluid fibers, droplets and combinations of the same, including hot melt adhesive and other fluids, that comprises, spraying a stream of such pressurized fluid through a fine orifice and along a predetermined direction in free flight, and simultaneously funneling a cone of pressurized air symmetrically about and against said stream, intersecting the same in its free flight below said orifice to control the nature, dimensions and pattern of the resulting fluid coating on surface disposed therebelow. Supplemental air controls are also providable for contouring and other effects.

Abstract translation: 本发明涉及一种控制一些高粘度流体纤维，液滴及其组合（包括热熔粘合剂和其它流体）的产生的装置和方法，其包括：将这种加压流体流喷射通过细 并且沿自由飞行中的预定方向沿着预定方向沿着自由飞行中的自由飞行同时地将加压空气锥体对称地围绕和抵靠所述流体溢流，以在其所述孔口下方的自由飞行中与其相交，以控制所得流体涂层在表面上的性质，尺寸和图案 在下面。 补充空气控制也可用于轮廓和其他效果。