公开(公告)号：US20160061740A1

公开(公告)日：2016-03-03

申请号：US14836629

申请日：2015-08-26

Applicant: Pacific Biosciences of California, Inc.

Inventor： Annette GROT ,  Ravi SAXENA ,  Paul LUNDQUIST

IPC: G01N21/78 ,  G02B27/42 ,  G02B5/28 ,  G02B5/18 ,  G02B5/20

CPC classification number: G01N21/6454 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/78 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2021/7756 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0873 ,  G02B5/1895 ,  G02B5/201 ,  G02B5/285 ,  G02B6/132 ,  G02B6/136 ,  G02B27/4238 ,  G02B27/4244 ,  G02B2006/12102 ,  G02B2006/12109 ,  H01L27/14621 ,  H01L27/14627 ,  H01L27/14685

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

Abstract translation: 提供了集成分析设备阵列及其生产方法。 阵列可用于高密度高分复用的光学反应，包括生化反应，如核酸测序反应。 这些器件允许使用诸如光谱，幅度和时间分辨率之类的特征或其组合来对光信号进行高灵敏度鉴别。 这些器件包括集成的衍射光束成形元件，其提供从光学反应发射的光的空间分离。

公开(公告)号：US09273353B2

公开(公告)日：2016-03-01

申请号：US14730989

申请日：2015-06-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael R. Gambini ,  John G. Atwood ,  Anthony L. Cerrone ,  Edward J. Lakatos ,  Eugene F. Young

IPC: C12M1/34 ,  C12M3/00 ,  C12Q1/68 ,  B01L7/00 ,  G01N21/27 ,  G01N21/64 ,  B01L3/00

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

公开(公告)号：US20160033399A1

公开(公告)日：2016-02-04

申请号：US14809054

申请日：2015-07-24

Applicant: Nanometrics Incorporated

Inventor： Andrew S. KLASSEN ,  Andrew J. Hazelton ,  Andrew H. Barada ,  Todd M. Petit ,  Chuan Sheng Tu

IPC: G01N21/47 ,  G01N21/01

CPC classification number: G01N21/4785 ,  G01N21/01 ,  G01N21/15 ,  G01N2021/151 ,  G01N2201/02 ,  G01N2201/068 ,  G03F7/70933

Abstract: An integrated metrology module includes a chuck for holding a sample and positioning the sample with respect to an optical metrology device, a reference chip for the optical metrology device, the reference chip being movable to various positions with respect to the optical metrology device, and a reference chip purge device provides a flow of purge gas or air over the reference chip while the reference chip is in the various positions. The reference chip purge device may be static or movable with the reference chip.

Abstract translation: 综合测量模块包括用于保持样品并相对于光学测量装置定位样品的卡盘，用于光学测量装置的参考芯片，参考芯片可移动到相对于光学测量装置的各个位置，以及 参考芯片清洗装置在参考芯片处于各种位置时提供吹扫气体或空气流过参考芯片。 参考芯片清洗装置可以是参考芯片的静态或可移动的。

公开(公告)号：US20160025635A1

公开(公告)日：2016-01-28

申请号：US14775839

申请日：2013-03-14

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Zhiyong LI ,  Ning GE ,  Steven J. BARCELO ,  Huei Pei KUO

IPC: G01N21/65 ,  C25D1/20 ,  G01N21/64 ,  C25D1/02 ,  G01N27/04 ,  G01N27/22

CPC classification number: G01N21/658 ,  B82Y30/00 ,  C25D1/02 ,  C25D1/20 ,  G01N21/648 ,  G01N27/04 ,  G01N27/22 ,  G01N33/02 ,  G01N33/22 ,  G01N2201/068

Abstract: Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining a first chamber and a substrate coupled to the housing. The substrate includes nanostructures positioned within the first chamber. The nanostructures are to react to the substance when exposed thereto. The device includes a first heater positioned within the first chamber. The heater is to heat at least a portion of the substance to ready the device for analysis.

Abstract translation: 公开了检测物质的装置和制造这种装置的方法。 用于检测物质的示例性装置包括限定第一室的壳体和联接到壳体的衬底。 衬底包括位于第一腔内的纳米结构。 当暴露于其中时，纳米结构将与物质反应。 该装置包括位于第一室内的第一加热器。 加热器是加热物质的至少一部分以准备用于分析的装置。

公开(公告)号：US09234839B2

公开(公告)日：2016-01-12

申请号：US14079280

申请日：2013-11-13

Applicant: JDS Uniphase Corporation

Inventor： Curtis R. Hruska ,  Charles A. Hulse ,  Brett J. Bryars ,  Marc K. Von Gunten ,  Christopher G. Pederson ,  Nada A. O'Brien ,  Jerry Zieba

IPC: G01J3/42 ,  G01N21/359 ,  G01J5/08

CPC classification number: G01N21/35 ,  G01J3/0205 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/26 ,  G01J3/42 ,  G01J5/08 ,  G01J2003/1234 ,  G01N21/359 ,  G01N2201/0221 ,  G01N2201/061 ,  G01N2201/068

Abstract: A portable spectrometer device includes an illumination source for directing at a sample, and a tapered light pipe (TLP) for capturing light interacting with the sample at a first focal ratio and for delivering the light at a second focal ratio lower than the first focal ratio. A linearly variable filter (LVF) separates the captured light into a spectrum of constituent wavelength signals; and a detector array, including a plurality of pixels, each of the plurality of pixels disposed to receive at least a portion of a plurality of the constituent wavelength signals provides a power reading for each constituent wavelength. Preferably, the TLP is lensed at one end, and recessed in a protective boot with stepped inner walls. The gap between the TLP and LVF is minimized to further enhance resolution and robustness.

Abstract translation: 便携式光谱仪装置包括用于引导样品的照明源和用于以第一焦距比捕获与样品相互作用的光的锥形光管（TLP），并且以比第一焦距比低的第二焦距传送光 。 线性可变滤波器（LVF）将捕获的光分离成波长信号的频谱; 以及包括多个像素的检测器阵列，所述多个像素中的每一个被设置为接收多个所述组成波长信号的至少一部分，为每个构成波长提供功率读数。 优选地，TLP在一端镜片，并且凹陷在具有阶梯状内壁的保护靴中。 TLP和LVF之间的差距被最小化以进一步提高分辨率和鲁棒性。

公开(公告)号：US20150377859A1

公开(公告)日：2015-12-31

申请号：US14754594

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： Martin Krauss ,  Maura Mahon ,  Adrew E. King ,  Steve Cooper ,  James Ingle ,  Gerald Thomas ,  David Barsic ,  Neal Andrews ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC: G01N33/497 ,  G01N21/64

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

Abstract translation: 分析盒包括主体部分和过滤器组件。 主体部分包括限定上室的上部和限定流体室的下部。 过滤器组件可沿着过滤器组件路径在第一位置和第二位置之间移动。 过滤器组件具有通过其限定的开口。 在第一位置，开口部分地限定上室，并且在第二位置，开口部分地限定流体室。

公开(公告)号：US20150377858A1

公开(公告)日：2015-12-31

申请号：US14754567

申请日：2015-06-29

Applicant: Gerald Thomas ,  Brian Young ,  Juven Lara ,  Charles Noll ,  James Ingle

Inventor： Gerald Thomas ,  Brian Young ,  Juven Lara ,  Charles Noll ,  James Ingle

IPC: G01N33/497

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: Fluorescence chromophores such as phenylene diamine derivatives can undergo oxidative coupling and polymerization to form optical, colorimetric and fluorogenic, multimers and polymers. The presence of carbonyl containing moieties such as aldehydes and ketones under favorable environmental conditions can initiate, catalyze, accelerate and modulate this reaction which in turn provides a mechanism for the detection and quantitation of such moieties. Selected phenylene diamine derivatives can be used for the detection and quantitation of aldehyde and ketones via measurement of the reaction and the associated spectroscopic transformation. In particular, the use of meta-phenylene diamine (mPDA) and related compounds for aldehyde detection and quantitation is described. The method provides a convenient means for monitoring aldehyde and ketone levels without use of separation steps. The method is applicable to kinetic and quasi-endpoint detection assay formats.

Abstract translation: 荧光发色团如苯二胺衍生物可进行氧化偶联和聚合以形成光学，比色和荧光，多聚体和聚合物。 在有利的环境条件下，含有羰基的部分如醛和酮的存在可引发，催化，加速和调节该反应，而反应又提供了检测和定量这些部分的机理。 选择的苯二胺衍生物可用于通过测量反应和相关的光谱转化来检测和定量醛和酮。 特别地，描述了使用间苯二胺（mPDA）和相关化合物进行醛检测和定量。 该方法提供了在不使用分离步骤的情况下监测醛和酮水平的方便手段。 该方法适用于动力学和准终点检测测定方法。

公开(公告)号：US20150377748A1

公开(公告)日：2015-12-31

申请号：US14754534

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： Steve Cooper ,  Neal Andrews ,  Martin Krauss ,  Andrew E. King ,  Maura Mahon ,  Weston Myler ,  James Ingle ,  Gerald Thomas ,  Rachel Dreilinger ,  David Barsic ,  Rick Myers ,  Craig Carlsen ,  Scot Herbst ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC: G01N1/22 ,  G01N21/64 ,  G01D11/24 ,  G01N33/497

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

Abstract translation: 一种呼吸分析系统，其包括在其上端具有分析盒的手柄组件。 手柄包括具有压力开口的主体部分和其中的压力换能器。 分析盒包括主体部分，其具有限定呼吸室的上部，限定流体室的下部和可在呼吸捕获位置和分析位置之间移动的过滤器组件。 过滤器组件具有通过其限定的开口。 在呼吸捕获位置，开口部分地限定呼吸室，并且在分析位置中，开口部分地限定流体室。 该系统还包括具有壳体的分析装置，门，控制电动机的控制器和位于壳体内部的荧光检测组件和旋转组件。 旋转组件包括具有用于接收分析盒的漏斗部分的护罩。

公开(公告)号：US20150362433A1

公开(公告)日：2015-12-17

申请号：US14763483

申请日：2013-01-25

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Zhang-Lin ZHOU ,  Zhiyong LI ,  Ansoon KIM

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01N33/5432 ,  G01N2201/06113 ,  G01N2201/068 ,  Y10S977/892 ,  Y10S977/954

Abstract: The present disclosure is drawn to chemical sensing devices and associated methods. In an example, a chemical sensing device can include a substrate and an elongated nanostructure having an attachment end and a free end opposite the attachment end, the attachment end affixed to the substrate and the free end comprising a metal having a potential sensing ligand attached thereto via a covalent bond.

Abstract translation: 本公开涉及化学感测装置和相关方法。 在一个示例中，化学感测装置可以包括基底和细长的纳米结构，其具有附接端和与附接端相对的自由端，附着端固定在基底上，自由端包括具有附着于其上的电位感应配体的金属 通过共价键。

公开(公告)号：US20150346092A1

公开(公告)日：2015-12-03

申请号：US14691086

申请日：2015-04-20

Applicant: Electronics and Telecommunications Research Institute

Inventor： Dae Sik LEE ,  Moon Youn JUNG ,  Myeong Soo LEE ,  Wan Joong KIM ,  Byoung Goo JEON

IPC: G01N21/59 ,  G01N33/49

CPC classification number: G01N21/59 ,  G01N21/314 ,  G01N21/3151 ,  G01N33/49 ,  G01N2021/317 ,  G01N2201/061 ,  G01N2201/068

Abstract: Provided herein is an apparatus for measuring properties of a fluid, the apparatus including: a light emitting unit configured to emit a first light having a first wavelength and a second light having a second wavelength that is longer than the first wavelength, from outside a fluid accommodating unit where the fluid flows in and out to a measurement area inside the fluid accommodating unit; a light receiving unit disposed outside the fluid accommodating unit and configured to receive the first light and second light that passed the measurement area; and a measuring unit configured to measure the properties of the fluid based on an intensity of the first light and second light that the light emitting unit emitted and an intensity of the first light and second light that the light receiving unit received.

Abstract translation: 本文提供了一种用于测量流体性质的装置，该装置包括：发光单元，被配置为从流体外部发射具有第一波长的第一光和具有比第一波长长的第二波长的第二光 容纳单元，其中流体流入和流出到流体容纳单元内的测量区域; 光接收单元，设置在所述流体容纳单元的外部，并被配置为接收通过所述测量区域的所述第一光和第二光; 以及测量单元，被配置为基于发光单元发射的第一光和第二光的强度以及光接收单元接收的第一光和第二光的强度来测量流体的性质。