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公开(公告)号：US20160186255A1
公开(公告)日：2016-06-30
申请号：US14945256
申请日：2015-11-18
Applicant: Pacific Biosciences of California, Inc.
Inventor： Paul Lundquist , Stephen Turner
CPC classification number: C12Q1/6874 , B01L2300/0636 , C12Q1/6869 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7703 , G01N21/7743 , G01N2021/6439 , G01N2021/7786 , G01N2201/08 , G02B6/10 , G02B6/43
Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
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公开(公告)号：US20160178530A1
公开(公告)日：2016-06-23
申请号：US14905318
申请日：2014-07-17
Applicant: DE BEERS UK LTD
Inventor： Nicholas Matthew DAVIES , Siobhan D'GAMA , Peter Stanley ROSE , Maxwell Ralph WILLS
CPC classification number: G01N21/87 , B07C5/342 , G01N21/39 , G01N21/64 , G01N21/65 , G01N2201/06113 , G01N2201/068 , G01N2201/08
Abstract: Apparatus and corresponding methods for measuring a plurality of parameters of a cut gemstone while it is positioned at a single measurement location. Apparatus comprise a plurality of light sources, each configured to emit light at a different one of a plurality of emission wavelengths or ranges of wavelengths such that the emitted light illuminates at least part of the measurement location. Apparatus further comprise a sensor assembly configured to sense light at a plurality of sensing wavelengths or ranges of wavelengths for measuring the plurality of parameters. The sensed light is received at the sensor assembly from the measurement location as a result of illumination of a cut gemstone located at the measurement location.
Abstract translation: 用于在切割宝石位于单个测量位置时测量切割宝石的多个参数的装置和相应方法。 设备包括多个光源，每个光源被配置为以多个发射波长或波长范围中的不同的一个发射光，使得发射的光照亮测量位置的至少一部分。 设备还包括传感器组件，其被配置为感测用于测量多个参数的多个感测波长或波长范围的光。 由于位于测量位置处的切割宝石的照明，感测的光从测量位置在传感器组件处被接收。
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93.发明申请公开(公告)号：US20160139019A1
公开(公告)日：2016-05-19
申请号：US15001321
申请日：2016-01-20
Applicant: International Business Machines Corporation
Inventor： Phaedon Avouris , Michael Engel , Claudius Feger , Ronaldo Giro , Rodrigo Ferreira , Mathias Steiner
CPC classification number: G01N11/04 , G01N21/71 , G01N33/24 , G01N2011/008 , G01N2201/08 , G06F17/5009 , G06F17/5072 , G06F2217/16 , H01L29/1606 , H01L29/4966
Abstract: An Integrated Circuit (IC) chip with a lab-on-a-chip, a method of manufacturing the lab-on-a-chip and a method of using the lab-on-a-chip for fluid flow analysis in physical systems through combination with computer modeling. The lab-on-a-chip includes cavities in a channel layer and a capping layer, preferably transparent, covering the cavities. Gates control two dimensional (2D) lattice structures acting as heaters, light sources and/or sensors in the cavities, or fluid channels. The gates and two dimensional (2D) lattice structures may be at the cavity bottoms or on the capping layer. Wiring connects the gates and the 2D lattice structures externally.
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公开(公告)号：US20160113507A1
公开(公告)日：2016-04-28
申请号：US14919565
申请日：2015-10-21
Applicant: Parsin Haji Reza , Roger Zemp
Inventor： Parsin Haji Reza , Roger Zemp
CPC classification number: A61B5/0095 , G01N21/1702 , G01N21/1717 , G01N2021/1706 , G01N2021/1725 , G01N2201/06113 , G01N2201/08 , G01N2201/0846
Abstract: A photoacoustic remote sensing system (PARS) for imaging a subsurface structure in a sample has an excitation beam configured to generate ultrasonic signals in the sample at an excitation location; an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals; an optical system that focuses at least one of the excitation beam and the interrogation beam with a focal point that is below the surface of the sample; and a detector that detects the returning portion of the interrogation beam.
Abstract translation: 用于对样品中的地下结构进行成像的光声遥感系统（PARS）具有被配置为在激发位置处在样品中产生超声波信号的激发束; 入射在激发位置处的样品上的询问光束，询问光束从样品返回的指示所生成的超声信号的部分; 光学系统，其将至少一个激发光束和询问光束聚焦在低于样品表面的焦点; 以及检测器，其检测询问光束的返回部分。
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公开(公告)号：US20160091449A1
公开(公告)日：2016-03-31
申请号：US14964756
申请日：2015-12-10
Applicant: AgaMatrix, Inc.
Inventor： Sridhar Iyengar , Ian Harding , Charles Boiteau , Colin Butters
IPC: G01N27/327 , G01N33/487 , G01J1/42
CPC classification number: G01N27/3272 , G01J1/42 , G01N21/255 , G01N21/7703 , G01N21/8483 , G01N27/327 , G01N27/3273 , G01N33/48707 , G01N33/48771 , G01N2201/08
Abstract: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.
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Patent Agency Ranking
96.发明申请METHOD AND INTEGRATED DEVICE FOR ANALYZING LIQUID FLOW AND LIQUID-SOLID INTERFACE INTERACTION 有权用于分析液体流动和液体 - 界面交互的方法和集成装置公开(公告)号：US20160091405A1
公开(公告)日：2016-03-31
申请号：US14502897
申请日：2014-09-30
Applicant: International Business Machines Corporation
Inventor： Phaedon Avouris , Michael Engel , Claudius Feger , Ronaldo Giro , Rodrigo Ferreira , Mathias Steiner
CPC classification number: G01N11/04 , G01N21/71 , G01N33/24 , G01N2011/008 , G01N2201/08 , G06F17/5009 , G06F17/5072 , G06F2217/16 , H01L29/1606 , H01L29/4966
Abstract: An Integrated Circuit (IC) chip with a lab-on-a-chip, a method of manufacturing the lab-on-a-chip and a method of using the lab-on-a-chip for fluid flow analysis in physical systems through combination with computer modeling. The lab-on-a-chip includes cavities in a channel layer and a capping layer, preferably transparent, covering the cavities. Gates control two dimensional (2D) lattice structures acting as heaters, light sources and/or sensors in the cavities, or fluid channels. The gates and two dimensional (2D) lattice structures may be at the cavity bottoms or on the capping layer. Wiring connects the gates and the 2D lattice structures externally.
Abstract translation: 具有片上实验室的集成电路（IC）芯片，制造芯片实验室的方法以及在物理系统中使用芯片上的实验室进行流体流分析的方法 结合计算机建模。 芯片实验室包括通道层中的空腔和覆盖空腔的封盖层，优选是透明的。 门控制二维（2D）格子结构，用作空腔或流体通道中的加热器，光源和/或传感器。 门和二维（2D）格子结构可以在空腔底部或覆盖层上。 接线连接外部的门和2D格子结构。
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公开(公告)号：US09291569B2
公开(公告)日：2016-03-22
申请号：US14642139
申请日：2015-03-09
Applicant: Pacific Biosciences of California, Inc.
Inventor： Adrian Fehr , Nathaniel Joseph McCaffrey , Stephen Turner
IPC: G01N21/64 , B01L3/00 , G01N21/77 , G01N21/75 , B82Y20/00 , G01N33/543 , G02B6/122 , G01N21/03 , G01N21/05 , C12Q1/68
CPC classification number: C12Q1/6874 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , B01L2300/168 , B82Y20/00 , C12Q1/6825 , C12Q1/6869 , G01N21/03 , G01N21/0303 , G01N21/05 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N21/6456 , G01N21/648 , G01N21/75 , G01N21/77 , G01N33/54373 , G01N2021/0346 , G01N2021/6434 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/757 , G01N2021/7786 , G01N2201/067 , G01N2201/068 , G01N2201/08 , G02B6/1226 , Y10T436/143333
Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
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公开(公告)号：US20160069806A1
公开(公告)日：2016-03-10
申请号：US14844492
申请日：2015-09-03
Applicant: Pacific Biosciences of California, Inc.
Inventor： Adrian FEHR , Nathaniel Joseph McCaffrey , Stephen TURNER
CPC classification number: C12Q1/6874 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , B01L2300/168 , B82Y20/00 , C12Q1/6825 , C12Q1/6869 , G01N21/03 , G01N21/0303 , G01N21/05 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N21/6456 , G01N21/648 , G01N21/75 , G01N21/77 , G01N33/54373 , G01N2021/0346 , G01N2021/6434 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/757 , G01N2021/7786 , G01N2201/067 , G01N2201/068 , G01N2201/08 , G02B6/1226 , Y10T436/143333
Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
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公开(公告)号：US09267928B2
公开(公告)日：2016-02-23
申请号：US14644262
申请日：2015-03-11
Applicant: PerkinElmer Health Sciences, Inc.
Inventor： Gregory Hanlon , Timothy Neal
IPC: G01N21/00 , G01N30/74 , G01N21/01 , G01J3/10 , G01J3/02 , G01N21/03 , F21V29/02 , G01N30/86 , F21V29/67
CPC classification number: G01N30/74 , F21V29/67 , F21V29/673 , F21V29/677 , G01J3/0286 , G01J3/10 , G01N21/01 , G01N21/0332 , G01N30/8651 , G01N2201/061 , G01N2201/08
Abstract: A liquid sample analyzer includes a flow cell, a light source, and a lamp temperature management system. The flow cell is configured to receive a flow of a liquid sample from a liquid sample source. The light source includes a lamp configured to emit light to illuminate the flow of the liquid sample in the flow cell. The lamp temperature management system includes: an air flow generator operable to generate a turbulent air flow to cool the lamp; a thermally conductive primary housing encapsulating the lamp such that a primary air gap is provided between the primary housing and the lamp; and a thermally conductive secondary housing surrounding the primary housing and configured to deflect the turbulent air flow away from the primary housing.
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公开(公告)号：US20160041096A1
公开(公告)日：2016-02-11
申请号：US14919202
申请日：2015-10-21
Applicant: Artificial Sensing Instrument ASI AG
Inventor： Kurt Tiefenthaler
CPC classification number: G01N21/648 , G01N21/6486 , G01N21/7743 , G01N33/54373 , G01N2021/6463 , G01N2201/08 , G02B6/124 , G02B6/32 , G02B2006/12107 , Y10S385/901
Abstract: The present invention describes (bio)chemo-functional waveguide grating structures consisting of at least one (bio)chemo-functional waveguide grating structure unit or at least one (bio)chemo-functional sensor location with beam guidance permitting light beam separation, as well as detection methods for parallel analysis which are marking-free or based on marking.
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