公开(公告)号：US20060278072A1

公开(公告)日：2006-12-14

申请号：US11377818

申请日：2006-03-15

Applicant: Harold Kent ,  Steven Kent

Inventor： Harold Kent ,  Steven Kent

IPC: B01D53/22 ,  A61N1/00 ,  B01D59/12

CPC classification number: H05K7/06 ,  A61M25/0021 ,  A61M25/0023 ,  A61M25/0043 ,  A61M25/0045 ,  A61M25/005 ,  A61M2025/0037 ,  A61M2025/004 ,  B01L3/5027 ,  B81B2201/058 ,  B81C3/008 ,  H05K1/0272 ,  H05K1/182 ,  H05K1/183 ,  H05K3/341 ,  H05K3/3447 ,  H05K3/368 ,  H05K3/4046 ,  H05K2201/10265 ,  Y02P70/613 ,  Y10T29/4902 ,  Y10T29/49117 ,  Y10T137/0318 ,  Y10T137/8593

Abstract: A method and system for transporting a fluid, gas, semi-solid, cryogen, or particulate matter, or combination thereof, between a three-dimensional structure and a substantially two-dimensional structure is disclosed. A system and method for electrically coupling a three-dimensional structure to a substantially two dimensional structure is also disclosed.

Abstract translation: 公开了一种用于在三维结构和基本上二维结构之间输送流体，气体，半固体，低温或颗粒物质或其组合的方法和系统。 还公开了一种将三维结构电耦合到基本二维结构的系统和方法。

公开(公告)号：US20060234042A1

公开(公告)日：2006-10-19

申请号：US11318714

申请日：2005-12-27

Applicant: Rui Yang ,  Nathan Kreutter ,  Nanyakkara Somasiri

Inventor： Rui Yang ,  Nathan Kreutter ,  Nanyakkara Somasiri

IPC: B32B7/12 ,  B32B3/00

CPC classification number: B81C1/00071 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2400/0415 ,  B01L2400/086 ,  B81B2201/058 ,  B81C2201/014 ,  Y10T428/24917 ,  Y10T428/2804

Abstract: An etched dielectric film having an adhered etch stop layer for use in microfluidic devices. Channels, recesses, and other features can be etched into the films to make them suitable for use in microfluidic devices.

Abstract translation: 具有用于微流体装置的粘附蚀刻停止层的蚀刻电介质膜。 可以将通道，凹槽和其它特征蚀刻到膜中，使其适用于微流体装置。

公开(公告)号：US20060118511A1

公开(公告)日：2006-06-08

申请号：US11003067

申请日：2004-12-02

Applicant: Timothy Beerling ,  Marco Aimi

Inventor： Timothy Beerling ,  Marco Aimi

IPC: G01D15/00

CPC classification number: B01L3/0262 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0487 ,  B81B1/004 ,  B81B2201/057 ,  B81B2201/058 ,  B81B2203/0353 ,  H01H11/02 ,  H01H2029/008 ,  Y10T428/24273 ,  Y10T428/2902

Abstract: A micro-machined nozzle includes a substrate having a hole formed on a first side that extends partially through a thickness dimension of the substrate and a nozzle orifice formed on a second opposite side that communicates with the hole. The nozzle orifice has at least a portion of its interior wall serrated. A method of fabricating a micro-machined nozzle includes the steps of etching a first side of a silicon substrate to form a hole that extends partially through a thickness dimension of the substrate and etching a second opposite side of the silicon substrate to form a serrated nozzle orifice that communicates with the hole.

Abstract translation: 微加工喷嘴包括：基板，其具有形成在第一侧上的部分地延伸穿过基板的厚度尺寸的孔;以及形成在与孔连通的第二相对侧上的喷嘴孔。 喷嘴孔具有其内壁的至少一部分锯齿状。 一种制造微加工喷嘴的方法包括以下步骤：蚀刻硅衬底的第一面以形成部分延伸穿过衬底的厚度尺寸并蚀刻硅衬底的第二相对侧以形成锯齿状喷嘴的孔 孔与孔连通。

公开(公告)号：US06981522B2

公开(公告)日：2006-01-03

申请号：US10160393

申请日：2002-05-30

Applicant: Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker

Inventor： Stephen D. O'Connor ,  Christoph D. Karp ,  Eugene Dantsker

IPC: F15C1/06 ,  F16K37/00

CPC classification number: B01F5/064 ,  B01F13/0059 ,  B01F15/0264 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/00869 ,  B01J2219/00891 ,  B01J2219/00997 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B29C65/02 ,  B29C66/02 ,  B29C66/026 ,  B29C66/71 ,  B29K2023/00 ,  B29K2023/12 ,  B29L2031/756 ,  B81B2201/058 ,  B81C3/008 ,  G01N30/6095 ,  G01N2030/565 ,  Y10T137/206 ,  Y10T137/212 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/8359 ,  B29C2035/0827 ,  B29K2067/00

Abstract: Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features (“common fluids”) may be input into a microfluidic device or system through one or more distributing inputs that divide and distribute the common fluids as desired. The use of a multi-layer fabrication technique allows multiple distributing inputs to distribute to multiple functional features in a microfluidic device without undesirable fluid channel intersections.

公开(公告)号：US20050287047A1

公开(公告)日：2005-12-29

申请号：US11198172

申请日：2005-08-08

Applicant: James Clarkin ,  Gary Nelson ,  Robert Macomber

Inventor： James Clarkin ,  Gary Nelson ,  Robert Macomber

IPC: G01N21/03 ,  B01L3/00 ,  B81B1/00 ,  C12M3/04 ,  G01N35/08 ,  G01N37/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0654 ,  B81B1/002 ,  B81B2201/058 ,  G01N27/44721

Abstract: Micro channel array devices drawn from a bulk preform having an array of components to reduce the cross section. The reduced cross section fiber like structure is cut to produce individual arrays of small scale. End caps are drawn and optionally micro machined. The end caps are used to provide input and output ports and other structures for use with the micro channel arrays. A micro channel array may be used with different end caps for analysis and may form a lab on a chip or a component thereof.

Abstract translation: 从具有组件阵列的大块预制件中绘制的微通道阵列器件以减小横截面。 切割截面纤维的结构被切割以产生小规模的单个阵列。 绘制端盖并可选择微加工。 端盖用于提供用于微通道阵列的输入和输出端口和其他结构。 微通道阵列可以与不同的端盖一起用于分析，并且可以在芯片或其部件上形成实验室。

公开(公告)号：US20050176245A1

公开(公告)日：2005-08-11

申请号：US10774699

申请日：2004-02-09

Applicant: Anatoli Melechko ,  Timothy McKnight ,  Michael Guillorn ,  Bojan Ilic ,  Vladimir Merkulov ,  Mitchel Doktycz ,  Douglas Lowndes ,  Michael Simpson

Inventor： Anatoli Melechko ,  Timothy McKnight ,  Michael Guillorn ,  Bojan Ilic ,  Vladimir Merkulov ,  Mitchel Doktycz ,  Douglas Lowndes ,  Michael Simpson

IPC: B01D67/00 ,  B01D71/02 ,  B01J23/755 ,  B01L3/00 ,  H01L21/44

CPC classification number: B01D67/0062 ,  B01D67/0069 ,  B01D67/0072 ,  B01D71/02 ,  B01D71/027 ,  B01D2323/24 ,  B01D2325/08 ,  B01J23/755 ,  B01J35/0013 ,  B01J35/006 ,  B01J37/0238 ,  B01J37/342 ,  B01L3/5027 ,  B01L2300/0663 ,  B01L2300/0896 ,  B81B2201/058 ,  B81B2203/0361 ,  B81C1/00119 ,  B82Y30/00 ,  Y10S977/70 ,  Y10S977/781 ,  Y10S977/784 ,  Y10T428/13 ,  Y10T428/1303 ,  Y10T428/1352 ,  Y10T428/1359 ,  Y10T428/139 ,  Y10T428/24174 ,  Y10T428/24273 ,  Y10T428/24322 ,  Y10T428/2902 ,  Y10T428/2991 ,  Y10T428/31504 ,  Y10T428/31678

Abstract: Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. A method includes depositing a catalyst particle on a surface of a substrate to define a deterministically located position; growing an aligned elongated nanostructure on the substrate, an end of the aligned elongated nanostructure coupled to the substrate at the deterministically located position; coating the aligned elongated nanostructure with a conduit material; removing a portion of the conduit material to expose the catalyst particle; removing the catalyst particle; and removing the elongated nanostructure to define a nanoconduit.

Abstract translation: 使用确定性生长的牺牲纳米模板描述了用于纳米转移和纳米应用的方法，制造商，机器和组合物。 一种方法包括在衬底的表面上沉积催化剂颗粒以限定确定性定位的位置; 在衬底上生长对准的细长纳米结构，对准的细长纳米结构的端部在确定性位置处耦合到衬底; 用导管材料涂覆对准的细长纳米结构; 去除所述导管材料的一部分以暴露所述催化剂颗粒; 除去催化剂颗粒; 并移除细长的纳米结构以限定纳米管。

公开(公告)号：US20050164118A1

公开(公告)日：2005-07-28

申请号：US10503161

申请日：2003-01-31

Applicant: Claus Barholm -Hansen ,  Jacques Jonsmann

Inventor： Claus Barholm -Hansen ,  Jacques Jonsmann

IPC: B01J19/00 ,  B01L3/00 ,  B81C1/00 ,  G03F7/00 ,  G03F7/038 ,  G03F7/40 ,  G03C1/76

CPC classification number: B81C3/001 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01L3/5027 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00357 ,  B81C2201/019 ,  G03F7/0012 ,  G03F7/0385 ,  G03F7/40

Abstract: A method of joining a workpiece and a microstructure by light exposure, a microstructure obtainable by the method comprising a workpiece joined thereto, means thereto and use thereof; in particular a microstructure-forming composition comprising a light-sensitive, structure-forming material comprising one or more photo resist materials which are sensitive to preferably UV-light, and a light-absorbing material comprising one or more light-absorbing substances absorbing preferably IR light and being in an amount sufficient to produce heat upon exposure to said absorbed light; a microstructure-forming preparation comprising such composition; a method of producing a microstructure on a substrate; and a microstructure obtainable by the method; a method of joining a workpiece and a microstructure, a microstructure obtainable by the method comprising a workpiece joined thereto, e.g. for producing closed micro flow channels in a micro flow system; and use of such a microstructure, e.g. in lab-on-chip applications, in point-of-care systems, in high-through-put screening systems, preferably in systems for screening active compounds in fluids, in particular biological fluids.

Abstract translation: 通过曝光接合工件和微结构的方法，通过包括与其接合的工件的方法可获得的微观结构及其用途; 特别是一种微结构形成组合物，其包含光敏的结构形成材料，其包含对优选紫外光敏感的一种或多种光致抗蚀剂材料，以及光吸收材料，其包含一种或多种吸收物质优选吸收IR 并且其量足以在暴露于所述吸收的光时产生热量; 包含这种组合物的微结构形成制剂; 在基板上制造微观结构的方法; 和通过该方法获得的微结构; 接合工件和微结构的方法，通过包括与其连接的工件的方法获得的微结构，例如。 用于在微流量系统中产生闭合的微流通道; 并使用这种微结构，例如。 在片上应用中，在点到点系统中，在高通量筛选系统中，优选用于筛选流体中特别是生物流体中的活性化合物的系统。

公开(公告)号：US06869818B2

公开(公告)日：2005-03-22

申请号：US10298847

申请日：2002-11-18

Applicant: James M. Harris ,  Sapna Patel

Inventor： James M. Harris ,  Sapna Patel

IPC: B81B7/00 ,  B81C99/00 ,  F16K99/00 ,  H01L21/02 ,  H01L21/66 ,  H01L23/544 ,  H01L21/00

CPC classification number: H01L22/20 ,  B81B7/0012 ,  B81B2201/054 ,  B81B2201/058 ,  B81C99/0045 ,  B81C2203/038 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0036 ,  F16K99/0059 ,  F16K2099/0074 ,  H01L21/02071 ,  H01L22/24 ,  H01L22/34

Abstract: A method for producing a corrosion-resistant channel in a wetted path of a silicon device enables such device to be used with corrosive compounds, such as fluorine. A wetted path of a MEMS device is coated with either (1) an organic compound resistant to attack by atomic fluorine or (2) a material capable of being passivated by atomic fluorine. The device is then exposed to a gas that decomposes into active fluorine compounds when activated by a plasma discharge. One example of such a gas is CF4, an inert gas that is easier and safer to work with than volatile gases like ClF3. The gas will passivate the material (if applicable) and corrode any exposed silicon. The device is tested in such a manner that any unacceptable corrosion of the wetted path will cause the device to fail. If the device operates properly, the wetted path is deemed to be resistant to corrosion by fluorine or other corrosive compounds, as applicable.

公开(公告)号：US20050047969A1

公开(公告)日：2005-03-03

申请号：US10871498

申请日：2004-06-18

Applicant: Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults

Inventor： Mingqi Zhao ,  Iuliu Blaga ,  Luc Bousse ,  John Stults

IPC: H03H19/00 ,  B01L3/00 ,  B01L3/02 ,  B81B1/00 ,  G01D5/20 ,  G01N20060101 ,  G01N27/447 ,  H01J49/04

CPC classification number: H01J49/167 ,  B01L3/0268 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/027 ,  B81B1/008 ,  B81B2201/058 ,  G01N27/44717 ,  H01J49/0018

Abstract: A microfluidic chip formed with multiple fluid channels terminating at a tapered electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels may terminate at an open-tip region of the electrospray tip. A covering plate may substantially enclose most portions of the fluid channels formed on the channel plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a tapered electrospray tip having an open-tip region.

Abstract translation: 微流体芯片形成有多个流体通道，终止于锥形电喷雾离子化尖端，用于质谱分析。 流体通道可以形成在与相应的储存器流体连通的通道板上。 电喷雾尖端可以沿着通道板的限定的远侧部分形成，其可以包括单个或多个锥形表面。 流体通道可以终止于电喷雾尖端的开口尖端区域。 覆盖板可以基本上封闭形成在通道板上的除了开口尖端区域之外的流体通道的大部分。 本发明的另一方面提供了在单个微流体芯片中流过单个流体通道的多个样品进行质谱分析的方法，所述单个微流体芯片由具有开口尖端区域的锥形电喷雾尖端形成。

公开(公告)号：US06857449B1

公开(公告)日：2005-02-22

申请号：US10675567

申请日：2003-09-30

Applicant: Calvin Y. H. Chow

Inventor： Calvin Y. H. Chow

IPC: B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  C40B60/14 ,  F15C1/06

CPC classification number: B01L3/5027 ,  B01J19/0093 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00587 ,  B01J2219/00702 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0487 ,  B81B1/004 ,  B81B2201/0214 ,  B81B2201/058 ,  C40B60/14 ,  Y10T137/2224 ,  Y10T137/8242 ,  Y10T137/8326

Abstract: The present invention provides multi-layer microfluidic systems, by providing additional substrate layers, e.g., third, fourth, fifth and more substrate layers, mated with the typically described first and second layers. Microfabricated elements, e.g., grooves, wells and the like, are manufactured into the surfaces between the various substrate layers. These microfabricated elements define the various microfluidic aspects or structures of the overall device, e.g., channels, chambers and the like. In preferred aspects, a separate microscale channel network is provided between each of the substrate layers.

Abstract translation: 本发明通过提供与通常描述的第一和第二层配合的附加衬底层，例如第三，第四，第五和更多衬底层来提供多层微流体系统。 诸如凹槽，井等的微细元件被制造成各种基底层之间的表面。 这些微制造元件限定了整个装置的各种微流体方面或结构，例如通道，室等。 在优选的方面，在每个基底层之间提供单独的微细通道网络。