公开(公告)号：US20150338403A1

公开(公告)日：2015-11-26

申请号：US14811639

申请日：2015-07-28

Applicant: Oregon State University

Inventor： Alan X. Wang ,  Gregory L. Rorrer

IPC: G01N33/553 ,  G01N21/65

CPC classification number: G01N33/552 ,  G01N21/658 ,  G01N33/54373 ,  G01N33/553 ,  G01N2201/068

Abstract: A composition comprising a diatom frustule and a metal coating, and a method for making the same, are disclosed herein. The metal coating may comprise a metal film or metal nanoparticles, which may be attached to the surface via a linker. The composition has a surface coverage ratio of from about 1% to about 100%. The composition may also comprise an antibody. Also disclosed is a method for using the composition comprising contacting the composition with a target molecule, exposing the composition to light, and measuring the resulting Raman scattering.

Abstract translation: 本文公开了包含硅藻圆锥体和金属涂层的组合物及其制备方法。 金属涂层可以包括金属膜或金属纳米颗粒，其可以通过连接体连接到表面。 组合物的表面覆盖率为约1％至约100％。 组合物还可以包含抗体。 还公开了使用组合物的方法，包括使组合物与靶分子接触，将组合物暴露于光下，并测量所得到的拉曼散射。

公开(公告)号：US20150300948A1

公开(公告)日：2015-10-22

申请号：US14390523

申请日：2013-04-04

Applicant: Dräger Medical GmbH

Inventor： Ralf BUCHTAL ,  Peter DREYER ,  Livio FORNASIERO

IPC: G01N21/3504 ,  G01J3/42 ,  G01J3/26

CPC classification number: G01N21/3504 ,  G01J3/26 ,  G01J3/42 ,  G01J3/433 ,  G01N2201/061 ,  G01N2201/0662 ,  G01N2201/068

Abstract: A device for recording an absorption spectrum of a fluid has a radiation source (1) that emits a radiation in a spectral range along a beam path (11), a measuring path (5), along which the radiation passes through the fluid and arranged in the beam path, a tunable Fabry-Perot interferometer (7), arranged in the beam path and transmitting radiation in the spectral range as a displaceable bandpass filter, and a detector (9, 35) measuring the intensity of the radiation in the spectral range. An etalon (3) is arranged for spectral modulation of radiation in the beam path and has a plurality of transmission maxima (17) in the spectral range. The bandpass filter, formed by the Fabry-Perot interferometer (7), is displacable across the spectral range such that spectral modulation of the radiation by the etalon (3) is measured by the detector (9, 35) as a modulation of radiation intensity over time.

Abstract translation: 用于记录流体的吸收光谱的装置具有辐射源（1），其沿着光束路径（11）发射光谱范围内的辐射;辐射通过流体的测量路径（5），并布置 在光束路径中，布置在光束路径中的可调谐法布里 - 珀罗干涉仪（7），并且在光谱范围内传输辐射作为可移位带通滤波器，以及检测器（9,35），其测量光谱中的辐射强度 范围。 标准具（3）被布置用于光束路径中的辐射的光谱调制，并且在光谱范围内具有多个透射最大值（17）。 由法布里 - 珀罗干涉仪（7）形成的带通滤波器可在整个光谱范围内置换，使得由标准具（3）辐射的光谱调制由检测器（9,35）测量，作为辐射强度的调制 随着时间的推移。

公开(公告)号：US20150279616A1

公开(公告)日：2015-10-01

申请号：US14667292

申请日：2015-03-24

Applicant: TESCAN ORSAY HOLDING, a.s. ,  WITec GmbH

Inventor： Jaroslav Jiruse ,  Olaf Hollricher ,  Martin Hanicinec

IPC: H01J37/28 ,  G01Q30/02 ,  H01J37/18 ,  G01N21/65 ,  H01J37/20

CPC classification number: H01J37/28 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/061 ,  G01N2201/068 ,  G01Q30/025 ,  H01J37/18 ,  H01J37/20 ,  H01J37/226 ,  H01J37/228 ,  H01J37/26 ,  H01J2237/024 ,  H01J2237/063 ,  H01J2237/08 ,  H01J2237/24475 ,  H01J2237/2448 ,  H01J2237/2583 ,  H01J2237/2801 ,  H01J2237/2802

Abstract: A system uses number of analytical devices such as an electron microscope a Raman microscope, an ion beam column and a scanning probe microscope for sample analysis concurrent, consecutive or with the mutual correlation of the analysis performed by the different devices in the same sample area using the connection of the Raman microscope optical objective lens and objective manipulator, that significantly reduces time needed for analyzing by Raman microscope together with other devices and maintains high quality of the sensed signals comparable to stand alone analytical devices.

Abstract translation: 系统使用电子显微镜，拉曼显微镜，离子束柱和扫描探针显微镜等分析装置的数量，并行，连续或与相同样品区域中的不同装置进行的分析的相互关联，使用 拉曼显微镜光学物镜和物镜操纵器的连接，显着缩短了拉曼显微镜与其他设备一起分析所需的时间，并保持与独立分析设备相当的感测信号的高质量。

公开(公告)号：US20150247724A1

公开(公告)日：2015-09-03

申请号：US14630950

申请日：2015-02-25

Applicant: CANON KABUSHIKI KAISHA

Inventor： Hiroyuki Yuki ,  Takashi Seki

IPC: G01B11/30 ,  G01N21/57

CPC classification number: G01B11/306 ,  G01B11/303 ,  G01N21/55 ,  G01N21/57 ,  G01N2201/061 ,  G01N2201/068

Abstract: An optical system comprising: a light source; a photodetector; a first light-receiving system for causing the photodetector to receive first reflected light with a first angle of reflection from a surface; and a second light-receiving system for causing the photodetector to receive second reflected light with a second angle of reflection, different from the first angle of reflection, from the surface is provided. Here, an incident area on the surface, in which light generating the first reflected light is incident, is spaced apart from an exiting area on the surface, which light, to be incident on the photodetector from the surface via the second light-receiving system, exits.

Abstract translation: 一种光学系统，包括：光源; 光检测器; 第一光接收系统，用于使光电检测器从表面接收具有第一反射角的第一反射光; 以及第二光接收系统，用于使所述光电检测器从所述表面接收具有与所述第一反射角不同的第二反射角的第二反射光。 这里，产生第一反射光的光入射的表面上的入射区域与表面上的出射区域间隔开，该光从第二光接收系统的表面入射到光电检测器上 ，退出。

公开(公告)号：US20150177147A1

公开(公告)日：2015-06-25

申请号：US14406103

申请日：2012-06-05

Applicant: Steven L. Mangan ,  Gary Jonas

Inventor： Steven L. Mangan ,  Gary Jonas

IPC: G01N21/64 ,  G06K9/00

CPC classification number: G01N21/6428 ,  G01N21/76 ,  G01N21/8483 ,  G01N33/04 ,  G01N33/5005 ,  G01N33/52 ,  G01N33/54366 ,  G01N2201/068 ,  G02B21/0008 ,  G02B21/361 ,  G02B21/365 ,  G06K9/00134 ,  G06K9/0014

Abstract: A biological fluid analysis system and method for measuring optical characteristics of a sample of biological fluid using a commercially available portable computing device having a camera, such as a smart phone. The system includes a scope, a case that attaches to the portable computing device, and a software application that runs on the portable computing device. Some embodiments of the invention include a sample slide having a viewing chamber that can be filled with a biological fluid to be analyzed by the biological fluid analysis system. The system may be adapted to analyze cow's milk to estimate the number of somatic cells per unit volume contained in the milk using a reagent that stains the somatic cells so that they will fluoresce when excited by light with a particular wavelength, with the light source in the scope being adapted to generate light of that particular wavelength.

Abstract translation: 一种用于使用具有诸如智能电话的照相机的市售便携式计算设备来测量生物流体样品的光学特性的生物流体分析系统和方法。 该系统包括作用域，连接到便携式计算设备的情况以及在便携式计算设备上运行的软件应用程序。 本发明的一些实施例包括具有观察室的样品载玻片，该观察室可填充有待生物流体分析系统分析的生物流体。 该系统可以适于分析牛奶，以使用污染体细胞的试剂来估计牛奶中每单位体积的体细胞数量，以便当被特定波长的光激发时它们将发荧光，光源在 该适用范围适于产生该特定波长的光。

公开(公告)号：US20150131087A1

公开(公告)日：2015-05-14

申请号：US14401455

申请日：2013-04-01

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kenshiro Ohtsubo ,  Hidetoshi Nishiyama ,  Takahiro Jingu ,  Masaaki Ito

IPC: G01N21/88 ,  G01N21/95

CPC classification number: G01N21/8806 ,  G01N21/8851 ,  G01N21/9501 ,  G01N21/95623 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/12

Abstract: To improve sensitivity of a defect inspection, it is required to decrease influence of excessive diffraction from a spatial filter. Further, it is preferable to secure signal intensity from defects and particles as much as possible, while the influence of the excessive diffraction is decreased as much as possible. The present invention is characterized in setting a width of a spatial filter surface such that an unnecessary image caused by diffraction, that is, an intensity of the excessive diffraction is sufficiently small with respect to an intensity of a desired image. In the present invention, an SN ratio that is an index for deciding a width of the spatial filter is calculated from a region subjected to the influence of the excessive diffraction in an inspection image, and a width of a shield unit of the spatial filter is set so as to maximize the SN ratio.

Abstract translation: 为了提高缺陷检查的灵敏度，需要减小空间滤波器过度衍射的影响。 此外，尽可能地尽可能地减少来自缺陷和颗粒的信号强度，同时尽可能地减少过度衍射的影响。 本发明的特征在于设置空间滤波器表面的宽度，使得由衍射引起的不需要的图像，即过度衍射的强度相对于期望的图像的强度足够小。 在本发明中，作为用于决定空间滤波器的宽度的指标的SN比是从检查图像中受到过度衍射的影响的区域算出的，空间滤波器的屏蔽单位的宽度为 设置为最大化SN比。

公开(公告)号：US08993700B2

公开(公告)日：2015-03-31

申请号：US13498090

申请日：2010-09-24

Applicant: Pierrick Buvat ,  Lucie Malosse ,  Alain Siove ,  Dominique Ades

Inventor： Pierrick Buvat ,  Lucie Malosse ,  Alain Siove ,  Dominique Ades

IPC: C08F24/00 ,  C07D311/00 ,  C09B69/10 ,  C09B57/02 ,  G01N33/52

CPC classification number: G01N21/64 ,  C08F220/68 ,  C09B57/02 ,  C09B69/109 ,  G01N33/0037 ,  G01N33/0047 ,  G01N33/0057 ,  G01N33/52 ,  G01N2201/06113 ,  G01N2201/068 ,  Y02A50/245 ,  Y10T428/2982 ,  Y10T436/163333 ,  Y10T436/173076

Abstract: Polymers and copolymers of polymerizable fluorescent compounds of 7-hydroxycoumarin such as Ethyl-2-methacrylate Umbelliferone-4-acetate are provided. In addition, a sensor comprising this polymer notably for detecting and/or assaying nitrated and organophosphorus compounds, explosives, and toxic compounds is provided.

Abstract translation: 提供了7-羟基香豆素的可聚合荧光化合物如2-乙基-2-甲基丙烯酸甲基松香酮-4-乙酸酯的聚合物和共聚物。 此外，提供了包含该聚合物的传感器，其特别用于检测和/或测定硝化和有机磷化合物，爆炸物和有毒化合物。

公开(公告)号：US08984453B2

公开(公告)日：2015-03-17

申请号：US13536625

申请日：2012-06-28

Applicant: Shmuel Mangan ,  Amir Sagiv ,  Mariano Abramson

Inventor： Shmuel Mangan ,  Amir Sagiv ,  Mariano Abramson

IPC: G06F17/50 ,  G01N21/00 ,  G03F1/84 ,  G03F7/20

CPC classification number: G01N21/8806 ,  G01N21/00 ,  G01N21/9501 ,  G01N2201/068 ,  G03F1/84 ,  G03F7/70116

Abstract: Methods and systems for designing a binary spatial filter based on data indicative of a desired exposure condition to be emulated by an inspection system, and for implementing the binary spatial filter in an optical path of the inspection system, thereby enabling emulation of the desired exposure condition by interacting a light beam of the inspection system with the binary spatial filter. The present method and systems enable on-the-fly and on-demand design and implementation/generation of spatial filters for use in inspection systems.

Abstract translation: 用于基于表示由检查系统仿真的期望曝光条件的数据设计二进制空间滤波器的方法和系统，以及用于在检查系统的光路中实现二进制空间滤波器，由此能够仿真期望的曝光条件 通过将检查系统的光束与二进制空间滤波器相互作用。 本方法和系统使得能够即时和按需设计和实现/生成用于检测系统的空间滤波器。

公开(公告)号：US20150022805A1

公开(公告)日：2015-01-22

申请号：US14507758

申请日：2014-10-06

Applicant: KLA-Tencor Corporation

Inventor： Vladimir Dribinski ,  Yung-Ho Alex Chuang ,  J. Joseph Armstrong ,  John Fielden

IPC: G01N21/88 ,  G01N21/94

CPC classification number: H01S5/0092 ,  C03B33/02 ,  C30B1/02 ,  C30B29/10 ,  C30B29/14 ,  C30B29/22 ,  C30B29/30 ,  C30B33/02 ,  G01N21/88 ,  G01N21/8806 ,  G01N21/94 ,  G01N21/9501 ,  G01N2201/06113 ,  G01N2201/0637 ,  G01N2201/068 ,  G02F1/353 ,  G02F1/3551 ,  G02F1/3553 ,  G02F1/37 ,  G02F2001/3505 ,  G02F2001/3507 ,  G02F2001/354 ,  G02F2202/20 ,  H01S3/0092 ,  H01S3/10 ,  H01S3/10038 ,  H01S3/10046 ,  H01S3/11

Abstract: An optical system for detecting contaminants and defects on a test surface includes an improved laser system for generating a laser beam and optics directing the laser beam along a path onto the test surface, and producing an illuminated spot thereon. A detector and ellipsoidal mirrored surface are also provided with an axis of symmetry about a line perpendicular to the test surface. In one embodiment, an optical system for detecting anomalies of a sample includes the improved laser system for generating first and second beams, first optics for directing the first beam of radiation onto a first spot on the sample, second optics for directing the second beam onto a second spot on the sample, with the first and second paths at different angles of incidence to the sample surface. In another embodiment, a surface inspection apparatus includes an illumination system configured to focus beams at non-normal incidence angles.

Abstract translation: 用于检测测试表面上的污染物和缺陷的光学系统包括用于产生激光束的改进的激光系统和将激光束沿着路径引导到测试表面上并在其上产生照明点的光学系统。 检测器和椭圆形镜面也具有围绕垂直于测试表面的线的对称轴。 在一个实施例中，用于检测样本异常的光学系统包括用于产生第一和第二光束的改进的激光系统，用于将第一辐射束引导到样品上的第一光点上的第一光学器件，用于将第二光束引导到 样品上的第二个点，第一和第二个路径与样品表面的入射角不同。 在另一个实施例中，表面检查装置包括被配置为以非正常入射角聚焦光束的照明系统。

公开(公告)号：US20150008340A1

公开(公告)日：2015-01-08

申请号：US14495241

申请日：2014-09-24

Applicant: OLYMPUS CORPORATION

Inventor： Katsumasa FUJITA ,  Takeharu NAGAI ,  Kenta SAITO ,  Masahito YAMANAKA ,  Shinichi TAKIMOTO

IPC: G01N21/64

CPC classification number: G02B21/0076 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/501 ,  G01N21/6458 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/068 ,  G01N2201/0697 ,  G01T1/2985

Abstract: A fluorescence observation method of the present invention for detecting plural types of fluorescence emitted from two or more kinds of fluorescent molecules includes: subjecting each of the two or more kinds of fluorescent molecules to multi-photon excitation by exciting light having an exciting wavelength equal to or shorter than 700 nm in a visible region, to generate fluorescence upon making use of an absorption wavelength band in a deep ultraviolet region of each of the two or more kinds of fluorescent molecules; and simultaneously detecting plural types of fluorescence generated on a shorter-wavelength side or on both of the shorter-wavelength side and a longer-wavelength side of the exciting wavelength of the exciting light.

Abstract translation: 本发明的用于检测从两种以上荧光分子发出的多种荧光的荧光观察方法包括：通过激发具有激发波长的光，使两种或更多种荧光分子中的每一种进行多光子激发 或者在可见光区域中短于700nm，在使用两种或更多种荧光分子的深紫外区域中的吸收波长带产生荧光; 并且同时检测在激发光的激发波长的短波长侧或短波长侧和长波长侧的两端产生的多种荧光。