公开(公告)号：US20080190171A1

公开(公告)日：2008-08-14

申请号：US11675043

申请日：2007-02-14

Applicant: Robert E. Higashi

Inventor： Robert E. Higashi

IPC: G01N1/44 ,  B81B7/02 ,  B81C1/00 ,  G01N30/06

CPC classification number: B81B3/0081 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2200/14 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/1827 ,  B81B2201/051 ,  B81B2201/058 ,  G01N30/6095 ,  G01N2030/025

Abstract: Embodiments of the invention relate to a fluid containment structure for a micro analyzer comprising one or more shelled thermal structures in contact with a thermally isolated component of the analyzer and wherein the shelled thermal structure comprises a conformal film and also comprises three walls of a channel and the thermally isolated component forms the fourth wall.

Abstract translation: 本发明的实施例涉及一种用于微分析器的流体容纳结构，其包括与分析仪的热隔离部件接触的一个或多个外壳热结构，并且其中所述带壳热结构包括保形膜，并且还包括三个通道壁和 热隔离部件形成第四壁。

公开(公告)号：US20080178987A1

公开(公告)日：2008-07-31

申请号：US12033958

申请日：2008-02-20

Applicant: Peng Zhou ,  Lincoln C. Young ,  Todd Roswech

Inventor： Peng Zhou ,  Lincoln C. Young ,  Todd Roswech

IPC: B29C65/72 ,  B29C65/54

CPC classification number: B29C66/54 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/084 ,  B29C65/04 ,  B29C65/08 ,  B29C65/4895 ,  B29C65/72 ,  B29C66/1122 ,  B29C66/341 ,  B29C66/543 ,  B29C66/71 ,  B29L2031/756 ,  B81B2201/051 ,  B81C3/001 ,  B81C2201/019 ,  B81C2203/032 ,  F04B43/043 ,  F04B43/06 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0021 ,  F16K99/0034 ,  F16K99/0055 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084 ,  F16K2099/0094 ,  B29K2069/00 ,  B29K2033/12 ,  B29K2033/08 ,  B29K2025/06

Abstract: A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time with RF or ultrasonic energy. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

Abstract translation: 一种制备聚合微流体结构的方法，其中微流体结构的两个或多个组分（层）用弱溶剂粘合剂，特别是乙腈或乙腈和醇的混合物固定粘合或层压。 在一个方面，乙腈可以用作弱溶剂粘合剂以包围在非弹性聚合物如聚苯乙烯，聚碳酸酯，丙烯酸或其它线性聚合物中或其上制造的微结构，以形成三维微流体网络。 该方法包括以下步骤：在给定的较低温度范围内用弱溶剂粘合剂润湿聚合物基材组分的至少一个相对表面，相邻接触相对表面，并在比 在一定时间内，RF或超声能量的较低温度范围。 接触的聚合物基材还可以在热活化之前对准，并在热活化期间被压缩。 还公开了层压聚合物微流体结构。

公开(公告)号：US20070275193A1

公开(公告)日：2007-11-29

申请号：US10589222

申请日：2005-02-14

Applicant: Joseph DeSimone ,  Jason Rolland ,  Ginger Rothrock

Inventor： Joseph DeSimone ,  Jason Rolland ,  Ginger Rothrock

IPC: B32B7/02 ,  B05D1/40 ,  B05D3/02 ,  C08F16/24 ,  C12M1/40 ,  H05H1/00 ,  G01F13/00 ,  C08G73/24 ,  B67D5/00 ,  B05D3/06

CPC classification number: B81C99/0085 ,  B01L3/0268 ,  B01L3/502707 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2400/0481 ,  B01L2400/0655 ,  B29C66/9121 ,  B81B2201/051 ,  B81C1/00206 ,  B81C2201/019 ,  B81C2201/034 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/0329 ,  Y10T428/13 ,  Y10T428/24

Abstract: The presently disclosed subject matter provides functional perfluoropolyether (PFPE) materials for use in fabricating and utilizing microscale devices, such as a microfluidic device. The functional PFPE materials can be used to adhere layers of PFPE materials to one another or to other substrates to form a microscale device. Further, the presently disclosed subject matter provides a method for functionalizing the interior surface of a microfluidic channel and/or a microtiter well. Also the presently disclosed subject matter provides a method for fabricating a microscale structure through the use of a sacrificial layer of a degradable material.

Abstract translation: 目前公开的主题提供了用于制造和利用诸如微流体装置的微量装置的功能性全氟聚醚（PFPE）材料。 功能性PFPE材料可用于将PFPE材料层彼此粘附或粘附到其它基底上以形成微米级装置。 此外，目前公开的主题提供了用于对微流体通道和/或微量滴定阱的内表面进行官能化的方法。 此外，目前公开的主题还提供了通过使用可降解材料的牺牲层来制造微结构的方法。

公开(公告)号：US20060057450A1

公开(公告)日：2006-03-16

申请号：US11119047

申请日：2005-04-28

Applicant: Jeffrey Morse ,  David Sopchak ,  Ravindra Upadhye ,  John Reynolds ,  Joe Satcher ,  Alex Gash

Inventor： Jeffrey Morse ,  David Sopchak ,  Ravindra Upadhye ,  John Reynolds ,  Joe Satcher ,  Alex Gash

IPC: H01M2/08 ,  H01M4/86 ,  H01M2/02 ,  H01M8/10

CPC classification number: H01M8/0618 ,  B01J19/0093 ,  B01J21/185 ,  B01J23/755 ,  B01J23/80 ,  B01J37/0203 ,  B01J37/0215 ,  B01J37/0242 ,  B01J37/036 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2219/00873 ,  B81B3/0094 ,  B81B2201/051 ,  B81B2203/0338 ,  B81C2201/0197 ,  B82Y30/00 ,  C01B3/326 ,  C01B3/583 ,  C01B2203/0233 ,  C01B2203/044 ,  C01B2203/047 ,  C01B2203/1005 ,  H01M4/8825 ,  H01M4/9016 ,  H01M4/96 ,  H01M8/0204 ,  H01M8/0215 ,  H01M8/0228 ,  H01M8/0247 ,  H01M8/0625 ,  H01M8/0631 ,  H01M2250/30 ,  Y02B90/18 ,  Y02P20/52

Abstract: A microreactor comprising a silicon wafer, a multiplicity of microchannels in the silicon wafer, and a catalyst coating the microchannels. In one embodiment the catalyst coating the microchannels comprises a nanostructured material. In another embodiment the catalyst coating the microchannels comprises an aerogel. In another embodiment the catalyst coating the microchannels comprises a solgel. In another embodiment the catalyst coating the microchannels comprises carbon nanotubes.

Abstract translation: 一种微反应器，包括硅晶片，硅晶片中的多个微通道和涂覆微通道的催化剂。 在一个实施方案中，涂覆微通道的催化剂包括纳米结构材料。 在另一个实施方案中，涂覆微通道的催化剂包含气凝胶。 在另一个实施方案中，涂覆微通道的催化剂包括溶胶凝胶。 在另一个实施方案中，涂覆微通道的催化剂包括碳纳米管。

公开(公告)号：US20060029528A1

公开(公告)日：2006-02-09

申请号：US11039940

申请日：2005-01-24

Applicant: Yuzuru Ito ,  Yoshishige Endo ,  Akira Koide

Inventor： Yuzuru Ito ,  Yoshishige Endo ,  Akira Koide

IPC: B01F3/08

CPC classification number: B01F13/0062 ,  B01F5/0451 ,  B01F5/0453 ,  B01F5/0456 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0066 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00889 ,  B01J2219/00891 ,  B81B1/00 ,  B81B2201/051

Abstract: The invention relates to a micro fluid chip that leads liquids supplied from a plurality of liquid supply ports, respectively, to a minute flow passage, performs mixing and reaction (chemical reaction) of the liquids in the minute flow passage, and obtains a liquid having been processed from a liquid discharge port. A micro fluid chip that leads liquids supplied from a plurality of liquid supply ports, respectively, to a minute flow passage, performs mixing/reaction of the liquids in the minute flow passage, and obtains a liquid having been processed from a liquid discharge port, the micro fluid chip comprising liquid supplies that supply a plurality of flows, which are formed by division of two kinds of liquids, respectively, in an alternate arrangement, and a flow flattening portion provided downstream of the liquid supplies to be configured in flow passage such that liquids alternately arranged are decreased in dimension as they go downstream and increased in dimension in a direction, which intersects the direction of arrangement and a direction of flow, as they go downstream, to be made substantially the same or slightly large in cross sectional area in the direction of flow. According to the invention, liquids of large flow rates can be processed at high speed and an apparatus is not made large in size.

公开(公告)号：US06935772B2

公开(公告)日：2005-08-30

申请号：US10444041

申请日：2003-05-21

Applicant: Christoph D. Karp ,  Stephen D. O'Connor ,  Paren P. Patel

Inventor： Christoph D. Karp ,  Stephen D. O'Connor ,  Paren P. Patel

IPC: B01D17/00 ,  B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  B81B1/00 ,  G01N35/00 ,  G05B7/00

CPC classification number: B01D17/00 ,  B01D17/0208 ,  B01D17/08 ,  B01F5/0604 ,  B01F13/0059 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0487 ,  B81B1/002 ,  B81B2201/051 ,  G01N2035/00237 ,  G01N2035/00544 ,  Y10T137/2191 ,  Y10T137/2224 ,  Y10T137/8122 ,  Y10T428/24562 ,  Y10T428/24744

Abstract: Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined through the entire thickness of stencil sheets. The overlap region may include an aperture-defining spacer layer, and/or an impedance element, such as a porous membrane, adapted to distribute at least one fluid across the entire width of the outlet channel to promote reliable fluid mixing.

Abstract translation: 提供能够有效地混合两种或多种流体的微流体装置。 限定在不同材料片材中的两个或多个微流体入口通道在与出口通道流体连通的重叠区域相遇。 通道是通过蜡纸的整个厚度来定义的。 重叠区域可以包括孔隙限定间隔层和/或阻抗元件，例如多孔膜，适于在出口通道的整个宽度上分布至少一种流体，以促进可靠的流体混合。

公开(公告)号：US20040164068A1

公开(公告)日：2004-08-26

申请号：US10784509

申请日：2004-02-23

Inventor： Flavio Villa ,  Ubaldo Mastromatteo ,  Gabriele Barlocchi ,  Mauro Cattaneo

IPC: H05B003/06

CPC classification number: B81C1/00119 ,  B01J19/0093 ,  B01L3/5027 ,  B01L3/502707 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2300/1883 ,  B81B2201/0214 ,  B81B2201/051 ,  B81B2203/0315 ,  B81B2203/0338 ,  B81C2201/053

Abstract: The microreactor is completely integrated and is formed by a semiconductor body having a surface and housing at least one buried channel accessible from the surface of the semiconductor body through two trenches. A heating element extends above the surface over the channel and a resist region extends above the heating element and defines an inlet reservoir and an outlet reservoir. The reservoirs are connected to the trenches and have, in cross-section, a larger area than the trenches. The outlet reservoir has a larger area than the inlet reservoir. A sensing electrode extends above the surface and inside the outlet reservoir.

Abstract translation: 微反应器是完全集成的，并且由具有表面的半导体主体形成，并且容纳至少一个通过两个沟槽从半导体主体表面接近的掩埋通道。 加热元件在通道之上延伸到表面之上，并且抗蚀剂区域在加热元件上方延伸并且限定入口储存器和出口储存器。 储存器连接到沟槽，并且在横截面中具有比沟槽更大的面积。 出口储存器具有比入口储存器更大的面积。 感测电极在表面和出口储存器的内部延伸。

公开(公告)号：US20030198130A1

公开(公告)日：2003-10-23

申请号：US10444041

申请日：2003-05-21

Applicant: Nanostream, Inc.

Inventor： Christoph D. Karp ,  Stephen D. O'Connor ,  Paren P. Patel

IPC: B01F013/00

CPC classification number: B01D17/00 ,  B01D17/0208 ,  B01D17/08 ,  B01F5/0604 ,  B01F13/0059 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0487 ,  B81B1/002 ,  B81B2201/051 ,  G01N2035/00237 ,  G01N2035/00544 ,  Y10T137/2191 ,  Y10T137/2224 ,  Y10T137/8122 ,  Y10T428/24562 ,  Y10T428/24744

Abstract: Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined through the entire thickness of stencil sheets. The overlap region may include an aperture-defining spacer layer, and/or an impedance element, such as a porous membrane, adapted to distribute at least one fluid across the entire width of the outlet channel to promote reliable fluid mixing.

Abstract translation: 提供能够有效地混合两种或多种流体的微流体装置。 限定在不同材料片材中的两个或多个微流体入口通道在与出口通道流体连通的重叠区域相遇。 通道是通过蜡纸的整个厚度来定义的。 重叠区域可以包括孔隙限定间隔层和/或阻抗元件，例如多孔膜，适于在出口通道的整个宽度上分布至少一种流体，以促进可靠的流体混合。

公开(公告)号：US09917148B2

公开(公告)日：2018-03-13

申请号：US14933958

申请日：2015-11-05

Applicant: International Business Machines Corporation

Inventor： Emmanuel Delamarche ,  Bilge Eker ,  Yuksel Temiz

IPC: H01L21/4763 ,  H01L29/04 ,  H01L29/16 ,  F16K99/00 ,  B01L3/00

CPC classification number: H01L29/045 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B81B2201/051 ,  B81B2203/0338 ,  B81B2203/0353 ,  B81C1/00087 ,  B81C2201/0133 ,  F16K99/0001 ,  F16K2099/0074 ,  H01L29/04 ,  H01L29/16

Abstract: The present invention is notably directed to a method of fabrication of a microfluidic chip (1), comprising: providing (S10-S20) a wafer (10, 12) of semiconductor material having a diamond cubic crystal structure, exhibiting two opposite main surfaces (S1, S2), one on each side of the wafer, and having, each, a normal in the or direction; and performing (S30) self-limited, anisotropic wet etching steps on each of the two main surfaces on each side of the wafer, to create a via (20, 20a) extending transversely through the thickness of the wafer, at a location such that the resulting via connects an in-plane microchannel (31) on a first one (S1) of the two main surfaces to a second one (S2) of the two main surfaces, the via exhibiting slanted sidewalls (20s) as a result of the self-limited wet etching. The invention further concerns microfluidic chips accordingly obtained.

公开(公告)号：US20160024673A1

公开(公告)日：2016-01-28

申请号：US14865095

申请日：2015-09-25

Applicant: GSI Helmholtzzentrum Fur Schwerionenforschung GmbH

Inventor： Thomas Cornelius ,  Wolfgang Ensinger ,  Reinhard Neumann ,  Markus Rauber

IPC: C25D1/00 ,  G01N25/00 ,  B01J19/00 ,  G01F1/688 ,  C25D1/04 ,  C25D5/18

CPC classification number: C25D1/006 ,  B01J19/0093 ,  B01J23/42 ,  B01J23/72 ,  B01J35/0006 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00846 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00873 ,  B22F1/0025 ,  B22F3/002 ,  B81B2201/0292 ,  B81B2201/051 ,  B81C99/0085 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C25D1/00 ,  C25D1/003 ,  C25D1/04 ,  C25D1/08 ,  C25D5/18 ,  G01F1/688 ,  G01N25/00 ,  Y10S977/762 ,  Y10T29/49117 ,  Y10T428/12201 ,  Y10T428/12389 ,  Y10T428/24562 ,  Y10T428/24893 ,  Y10T428/25

Abstract: A template based process is used for the production of the nanowire structural element, wherein the nanowires are electrochemically depositioned in the nanopores. The irradiation is carried out at different angles, such that a nanowire network is formed. The hollow chamber-like structure in the nanowire network is established through the dissolving of the template foil and removal of the dissolved template material. The interconnecting of the nanowires provides stability to the nanowire structural element and an electrical connection between the nanowires is created thereby.

Abstract translation: 使用基于模板的工艺来生产纳米线结构元件，其中纳米线被电化学沉积在纳米孔中。 以不同的角度进行照射，形成纳米线网络。 通过模板箔的溶解和去除溶解的模板材料来建立纳米线网络中的中空室状结构。 纳米线的互连提供了对纳米线结构元件的稳定性，并且由此形成纳米线之间的电连接。