公开(公告)号：US20160245755A1

公开(公告)日：2016-08-25

申请号：US15145840

申请日：2016-05-04

Applicant: Roche Diabetes Care, Inc.

Inventor： Gertrud Albrecht ,  Edgar Baumann ,  Markus Genthner-Riegler ,  Stefan Kalveram ,  Christian Niesporek ,  Kai-Oliver Schwenker ,  Markus Serr ,  Frederic Wehowski ,  Klaus Wettengel

IPC: G01N21/75

CPC classification number: G01N21/75 ,  G01J3/433 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/48707 ,  G01N33/4875 ,  G01N2021/7786 ,  G01N2201/0612 ,  G01N2201/0621 ,  G01N2201/0697

Abstract: Methods, analytical devices and analytical systems are provided for determining at least one analyte concentration in a body fluid sample. The methods, which may be incorporated into the devices and systems, can include the following steps: applying a body fluid to a test carrier; illuminating the test carrier by at least one light source, where the at least one light source is modulated by using at least two modulation frequencies; receiving light remitted by the test carrier by using at least one detector; determining an analyte concentration by evaluating at least one detector signal generated by the detector, where the detector signal is demodulated with the at least two modulation frequencies to generate at least two demodulated detector signals, each demodulated signal corresponding to one of the modulation frequencies; and detecting a fault by comparing the at least two demodulated detector signals.

Abstract translation: 提供了用于确定体液样品中至少一种分析物浓度的方法，分析装置和分析系统。 可以结合到装置和系统中的方法可以包括以下步骤：将体液施加到测试载体上; 通过至少一个光源照射测试载体，其中通过使用至少两个调制频率来调制至少一个光源; 通过使用至少一个检测器接收被测试载体所汇出的光; 通过评估由检测器产生的至少一个检测器信号来确定分析物浓度，其中检测器信号用至少两个调制频率解调以产生至少两个解调的检测器信号，每个解调信号对应于调制频率之一; 以及通过比较所述至少两个解调的检测器信号来检测故障。

公开(公告)号：US20160234904A1

公开(公告)日：2016-08-11

申请号：US15015810

申请日：2016-02-04

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke NAGAI ,  Keisuke OGAWA ,  Masato WATANABE ,  Kumiko JINGU ,  Masanori FUJIWARA ,  Tomoyuki YAMAZAKI

IPC: H05B33/08 ,  G01N21/33

CPC classification number: H05B33/0851 ,  G01N21/33 ,  G01N2201/0621 ,  G01N2201/0638 ,  G01N2201/0692 ,  G01N2201/0695

Abstract: Provided is an optical analyzer for performing a feedback control on the amount of light emitted from an LED as a light source, in which the configuration of an optical system is made simple and the degree of freedom in optical system arrangement is secured. An optical member 2 for focusing most of light while discharging part of the light as unfocused light is provided on an optical path from a light casting unit 1 to a sample cell 3. The optical member 2 can be achieved with a simple configuration, for example, two ball lenses spaced apart by a predetermined distance from each other. The light focused by the optical member 2 is cast as measurement light into the sample cell 3. Meanwhile, a second photodetector 5 is arranged at a position where the unfocused light reaches. The second photodetector 5 generates a detection signal in accordance with the amount of light that has entered the second photodetector 5 as monitored light, and a drive current to be supplied to an LED is controlled through a drive current controlling unit 6 and a current source 7 such that the amount of light is maintained at a fixed level.

Abstract translation: 提供了一种用于对从光源发出的光量进行反馈控制的光学分析器，其中光学系统的结构简单且光学系统布置的自由度得到确保。 在从光铸造单元1到样品池3的光路上设置有用于聚焦大部分光的光学构件2，同时以未聚焦的光排出部分光。光学构件2可以以简单的构造实现，例如 ，彼此隔开预定距离的两个球透镜。 将由光学构件2聚焦的光作为测量光铸造到样品池3中。同时，第二光电检测器5布置在未聚焦的光到达的位置。 第二光电检测器5根据作为监视光进入第二光电检测器5的光量产生检测信号，通过驱动电流控制单元6和电流源7控制提供给LED的驱动电流 使得光量保持在固定的水平。

公开(公告)号：US09370799B2

公开(公告)日：2016-06-21

申请号：US14876187

申请日：2015-10-06

Applicant: GII ACQUISITION, LLC

Inventor： Michael G. Nygaard ,  Laura L. Poletti

IPC: G01N21/00 ,  G01B11/24 ,  B07C5/342 ,  F42B35/00 ,  G01N21/90 ,  G01N21/95 ,  G01N21/952

CPC classification number: G01N21/952 ,  B07C5/342 ,  F42B35/00 ,  G01B11/2425 ,  G01B11/2433 ,  G01N21/909 ,  G01N21/9515 ,  G01N2201/02 ,  G01N2201/0621 ,  G01N2201/0638 ,  G01N2201/103 ,  G01N2201/12

Abstract: A method and system for optically inspecting a manufactured part at a single inspection station having a measurement axis are provided. The system comprises a fixture assembly which includes a rotatable first fixturing component to support a part in a generally vertical orientation and a rotatable second fixturing component mating with and removably connected to the first fixturing component to transmit torque from the first fixturing component to the second fixturing component. The second fixturing component includes a device for holding the part in a generally horizontal orientation and to permit rotation of the horizontally held part about the measurement axis between first and second predetermined angular positions about the axis. The system also comprises an actuator assembly, a backside illumination assembly, a frontside illumination device, a lens and detector assembly and at least one processor to process electrical signals generated by the lens and detector assembly.

Abstract translation: 提供了在具有测量轴的单个检查站上光学检查制造部件的方法和系统。 该系统包括夹具组件，其包括可旋转的第一夹持部件以支撑大致垂直的方向的部件，以及可旋转的第二夹紧部件，其与第一夹持部件配合并可拆卸地连接，以将转矩从第一夹持部件传递到第二夹持 零件。 第二固定部件包括用于将部件保持在大体上水平的方向并且允许水平保持部分围绕测量轴线围绕轴线在第一和第二预定角度位置之间旋转的装置。 该系统还包括致动器组件，背面照明组件，前侧照明装置，透镜和检测器组件以及用于处理由透镜和检测器组件产生的电信号的至少一个处理器。

公开(公告)号：US09347882B2

公开(公告)日：2016-05-24

申请号：US13737279

申请日：2013-01-09

Applicant: Molecular Devices, LLC

Inventor： Josef J. Atzler ,  Bernhard Schinwald

IPC: G01N21/76 ,  G01N21/64 ,  G01J3/02 ,  G01J3/10 ,  G01J3/427 ,  G01J3/44 ,  G01N21/17

CPC classification number: G01N21/64 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: Systems and methods for measuring a target in a sample, the target being capable of generating an emitted light in response to an excitation light. In an example system, an excitation light source generates the excitation light along an excitation optical path. An attenuation filter arrangement selectively adds an attenuation filter to the excitation optical path. The attenuation filter attenuates the excitation light by a corresponding attenuation factor. The excitation light exits the attenuation filter arrangement along the excitation optical path to illuminate the sample. A light energy detector receives the emitted light generated in response to the excitation light, and outputs a measured signal level corresponding to an emitted light level. If the light energy detector indicates an overflow, signal measurement is repeated with attenuation filters of increasing attenuation factors until the measured signal level does not overflow.

Abstract translation: 用于测量样本中的目标的系统和方法，所述目标能够响应于激发光产生发射的光。 在示例性系统中，激发光源沿着激发光路产生激发光。 衰减滤波器装置选择性地将衰减滤波器添加到激励光路。 衰减滤波器通过相应的衰减因子衰减激发光。 激发光沿着激发光路离开衰减滤光器装置以照亮样品。 光能检测器接收响应于激发光产生的发射光，并且输出与发射的光级相对应的测量信号电平。 如果光能检测器指示溢出，则使用增加衰减因子的衰减滤波器重复信号测量，直到测量信号电平不会溢出。

公开(公告)号：US20160084754A1

公开(公告)日：2016-03-24

申请号：US14661943

申请日：2015-03-18

Applicant: SIGMAR S.R.L.

Inventor： Osvaldo SALVATORE

IPC: G01N21/27 ,  G01N21/25 ,  G01N21/59

CPC classification number: G01N21/27 ,  F01N2560/12 ,  F01N2610/02 ,  F01N2900/1806 ,  F01N2900/1818 ,  G01N21/255 ,  G01N21/431 ,  G01N21/59 ,  G01N21/8507 ,  G01N2021/432 ,  G01N2201/0621 ,  G01N2201/0627

Abstract: A device for detecting the concentration of a given component in a solution, preferably the concentration of urea in solution with water includes a means for emitting radiation, at least one means for receiving radiation, which is prearranged for determining at least one characteristic of the radiation, and a light guide, which is prearranged for optically connecting the emitting means to the receiving means, wherein the light guide has at least one surface that is to come into contact with the solution so as to determine an interface of separation between the propagation medium and the solution. Control means are configured for obtaining a value indicating the concentration of the compound in the solution as a function of the signal coming from the receiving means.

Abstract translation: 用于检测溶液中给定组分的浓度的装置，优选地，用水溶液中的尿素浓度包括用于发射辐射的装置，用于接收辐射的至少一种装置，其被预先设置用于确定辐射的至少一种特性 以及导光板，其被布置用于将发射装置光学地连接到接收装置，其中光导具有至少一个与溶液接触的表面，以便确定传播介质之间的间隔界面 和解决方案。 控制装置被配置为根据来自接收装置的信号获得指示溶液中化合物的浓度的值。

公开(公告)号：US20150314334A1

公开(公告)日：2015-11-05

申请号：US14799740

申请日：2015-07-15

Applicant: Ackley Machine Corporation

Inventor： E. Michael ACKLEY ,  Mark FORD

IPC: B07C5/342 ,  G01N21/88 ,  G01N21/85 ,  B07C5/36 ,  B07C5/34

CPC classification number: B07C5/3422 ,  B07C5/34 ,  B07C5/3412 ,  B07C5/362 ,  B07C5/363 ,  G01N21/85 ,  G01N21/8806 ,  G01N21/8851 ,  G01N2021/845 ,  G01N2021/8592 ,  G01N2201/02 ,  G01N2201/062 ,  G01N2201/0621 ,  Y10T29/49826

Abstract: An inspection system is configured for use with a conveyer apparatus including carrier bars. Each carrier bar conveys pellet-shaped articles along a predetermined path. The inspection system includes at least one camera unit for sensing a predetermined characteristic of the pellet-shaped articles, a removal unit, and a controller. The removal unit, downstream from the at least one camera unit, removes selected pellet-shaped article(s) from the carrier bar(s) depending on whether the characteristic is sensed by the at least one camera unit. The controller is in communication with the at least one camera unit and the removal unit. The controller provides a signal to the removal unit in accordance with the sensed characteristic. The removal unit includes a rotatable ejection drum having extended vacuum nozzles along its length, equal to the number of articles conveyed in each carrier bar. Each vacuum nozzle selectively removes article(s) from the carrier bar(s) by suction.

Abstract translation: 检查系统构造成与包括承载杆的输送装置一起使用。 每个承载杆沿预定路径传送颗粒状物品。 检查系统包括用于感测颗粒状物品的预定特征的至少一个照相机单元，去除单元和控制器。 去除单元，从至少一个照相机单元的下游，取决于该特性是否被至少一个照相机单元感测到，从载体棒移除所选的颗粒状物品。 控制器与至少一个相机单元和拆卸单元通信。 控制器根据感测到的特性向去除单元提供信号。 移除单元包括可旋转的排出滚筒，其具有沿其长度延伸的真空喷嘴，其等于在每个承载杆中输送的物品的数量。 每个真空喷嘴通过抽吸选择性地从承载杆去除物品。

公开(公告)号：US09116124B2

公开(公告)日：2015-08-25

申请号：US14044247

申请日：2013-10-02

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller

IPC: G01N21/00 ,  G01N21/59 ,  B01L3/00 ,  G01N33/543 ,  G01N33/574 ,  B01L7/00

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

Abstract translation: 通常描述用于控制微流体系统中的流体的系统和方法。 在一些实施例中，流体的控制涉及使用来自在微流体系统中发生的一个或多个过程或事件的反馈。 例如，检测器可以在微流体系统的测量区域处检测一种或多种流体，并且可以对应于流体产生一个或多个信号或信号模式。 在某些情况下，信号的信号或图案可以对应于强度，持续时间，在时间上或相对于另一进程相对于第二位置的时间位置和/或事件之间的平均时间段。 使用该数据，控制系统可以确定是否调制微流体系统中随后的流体流动。 在一些实施方案中，这些和其它方法可用于进行质量控制以确定微流体系统的操作异常。

公开(公告)号：US20150146194A1

公开(公告)日：2015-05-28

申请号：US14385482

申请日：2013-03-18

Applicant: GEA Farm Technologies GmbH

Inventor： Karsten Schönrock ,  Marek Krasutzki ,  Sascha Bieletzki ,  Reinhard Balkenhol

IPC: G01N33/04 ,  G01F23/292 ,  G01N21/84

CPC classification number: G01N21/84 ,  A01J5/01 ,  A01J5/0135 ,  G01F23/292 ,  G01N33/04 ,  G01N2201/06113 ,  G01N2201/0621 ,  G01N2201/0696

Abstract: A method is proposed for ascertaining the quality and/or the composition of milk, in particular during a milking operation, in which the fill level of the milk in a chamber is determined. After the fill level of the milk in the chamber has been determined, the milk is irradiated using at least one radiation of a predefined wavelength. The intensity of the reflected radiation is measured. The fill level and the intensity of the reflected radiation represent a value pair. Characteristic values are stored in a memory. A characteristic value is assigned to the ascertained value pair. A statement about the quality and/or the composition of the milk can be made from the characteristic value thus ascertained.

Abstract translation: 提出了一种用于确定牛奶的质量和/或组成的方法，特别是在挤奶操作期间，其中确定了室中的奶的填充水平。 在确定了室中的牛奶的填充水平之后，使用预定波长的至少一种辐射照射牛奶。 测量反射辐射的强度。 反射辐射的填充水平和强度代表值对。 特征值存储在存储器中。 将特征值分配给确定的值对。 关于牛奶的质量和/或组成的陈述可以从由此确定的特征值进行。

公开(公告)号：US20150109614A1

公开(公告)日：2015-04-23

申请号：US14382334

申请日：2013-03-05

Applicant: BIOSURFIT S.A.

Inventor： Joao Manuel De Oliveira Garcia Da Fonseca

IPC: G01N21/41 ,  G01N21/552

CPC classification number: G01N33/54373 ,  G01N21/41 ,  G01N21/553 ,  G01N33/54346 ,  G01N33/553 ,  G01N2201/0612 ,  G01N2201/06146 ,  G01N2201/0621 ,  G01N2201/0635 ,  G01N2201/12723

Abstract: The disclosure relates to processing SPR signals, in particular signals obtained by illuminating a conductive surface with light at two wavelengths. Processing SPR signals can involve processing a first and second signal indicative of an intensity of light, received from a conductive layer at which SPR has occurred, as a function of angle of incidence, reflection or diffraction at the layer. The first and second signals each have two dips corresponding to a respective wavelength of the light at a respective angle at which surface plasmon resonance occurs for the respective wavelength and a peak between the two dips. The processing includes deriving a first and second value of a quantity indicative of signal magnitudes in the region of the peak. The first and second values can be compared to detect a change in refractive index at the layer after the first signal and before the second signal was captured.

Abstract translation: 本公开涉及处理SPR信号，特别是通过用两个波长的光照射导电表面而获得的信号。 处理SPR信号可以涉及处理表示从已经发生SPR的导电层接收的光的强度的第一和第二信号作为该层处的入射角，反射或衍射的函数。 第一和第二信号各自具有对应于在相应波长的相应波长处的两个倾斜，在该角度处，针对相应波长发生表面等离子体共振并且在两个下降之间产生峰值。 该处理包括导出指示峰值区域中的信号幅度的量的第一值和第二值。 可以比较第一和第二值以检测第一信号之后的层和第二信号被捕获之前的折射率的变化。

公开(公告)号：US20140306113A1

公开(公告)日：2014-10-16

申请号：US14318033

申请日：2014-06-27

Applicant: Xtralis Technologies Ltd

Inventor： Ron Knox ,  Karl Boettger ,  Kemal Ajay

IPC: G01N21/49

CPC classification number: G01N21/53 ,  G01N15/0205 ,  G01N15/0227 ,  G01N15/1434 ,  G01N21/49 ,  G01N21/538 ,  G01N2201/0621 ,  G01N2201/0696 ,  G08B17/107 ,  G08B17/113

Abstract: A particle detection system including; at least one light source adapted to illuminate a volume being monitored at at least two wavelengths; a receiver having a field of view and being adapted to receive light from at least one light source after said light has traversed the volume being monitored and being adapted to generate signals indicative of the intensity of light received at regions within the field of view of the receiver; a processor associated with the receiver adapted to process the signals generated by the receiver to correlate light received at at least two wavelengths in corresponding regions within the field of view of the receiver and generate an output indicative of the relative level of light received at the two wavelengths.

Abstract translation: 一种粒子检测系统，包括： 至少一个光源，其适于照亮在至少两个波长处被监测的体积; 具有视场的接收器，并且适于在所述光已经穿过被监视的体积之后接收来自至少一个光源的光，并且适于产生指示在所述视场内的区域中接收的光的强度的信号 接收器 与所述接收器相关联的处理器，其适于处理由所述接收器产生的信号，以将在所述接收机的视场内的相应区域中的至少两个波长处接收的光相关联，并且生成指示在所述两个接收器处接收的光的相对电平的输出 波长。