中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

155 records (took 0.025 seconds)

    Self-encoding sensor with microspheres
    111.
    发明授权
    Self-encoding sensor with microspheres 有权
    具有微球的自编码传感器

    公开(公告)号：US07348181B2

    公开(公告)日：2008-03-25

    申请号：US09287573

    申请日：1999-04-06

    Applicant: David R. Walt ,  Todd A. Dickinson

    Inventor： David R. Walt ,  Todd A. Dickinson

    IPC: G01N21/76

    CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

    Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

    Utilization of an infrared probe to discriminate between materials
    112.
    发明授权
    Utilization of an infrared probe to discriminate between materials 有权
    使用红外探头来区分材料

    公开(公告)号：US07167742B2

    公开(公告)日：2007-01-23

    申请号：US10142003

    申请日：2002-05-09

    Applicant: Nancy P. Camacho ,  Mathias P. G. Bostrom ,  Steve L. Bertha

    Inventor： Nancy P. Camacho ,  Mathias P. G. Bostrom ,  Steve L. Bertha

    IPC: A61B6/00

    CPC classification number: G01N21/552 ,  A61B5/0059 ,  A61B5/4504 ,  G01N21/35 ,  G01N21/359 ,  G01N2021/559 ,  G01N2201/0846

    Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.

    Abstract translation: 一种评估具有可区别的红外光谱的材料的表面的方法，包括（a）将红外光纤探针定位成与感兴趣区域的样品或材料的表面接触以检测衰减的全反射率，或者在 距离用于检测反射的区域的表面足够的距离，（b）检测中间或近红外辐射减弱了样品或材料表面的全反射或反射，（c）分析来自步骤（b）的红外辐射 ），用于峰高，峰面积，频率和化学计量参数中的至少一个，以及（d）当来自红外光纤探针的信号处于峰值高度，峰值面积之中的至少一个的预选值之间时，启动去除装置 ，样品的频率和化学计量参数。

    Spectrometer for measuring inelastically scattered light
    114.
    发明授权
    Spectrometer for measuring inelastically scattered light 有权
    用于测量非常散射光的光谱仪

    公开(公告)号：US07110108B2

    公开(公告)日：2006-09-19

    申请号：US10480479

    申请日：2002-06-12

    Applicant: Gerwin Jan Puppels

    Inventor： Gerwin Jan Puppels

    IPC: G01J3/44

    CPC classification number: G02B6/262 ,  G01N21/65 ,  G01N2021/656 ,  G01N2201/0846 ,  G02B2006/0325

    Abstract: The spectrum of light, inelastically scattered by a sample (16) is measured. The light is guided through a capillary (12) from and to the sample, at least in one of these directions, through the channel no inelastic scattering of light occurs which can form an interfering background when measuring on the sample. By guiding the light through the channel, inelastic scattering of this light is prevented and it becomes possible to guide scattered light back through the channel to spectral analysis equipment (14) without problems with inelastic scattering during the guidance of the light. Preferably, the light is guided through the channel of the capillary in both directions.

    Abstract translation: 测量由样品（16）非弹性散射的光谱。 通过通道，至少在这些方向中至少一个方向上，光从毛细管（12）引导到样品，不会发生光的非弹性散射，这可以在对样品进行测量时形成干扰背景。 通过引导光通过通道，防止该光的非弹性散射，并且可以在散射光的引导期间将散射光引导通过通道返回到光谱分析设备（14）而不存在非弹性散射的问题。 优选地，光在两个方向上被引导通过毛细管的通道。

    Fiber optic multitasking probe
    117.
    发明授权
    Fiber optic multitasking probe 失效
    光纤多任务探头

    公开(公告)号：US06514277B1

    公开(公告)日：2003-02-04

    申请号：US09329998

    申请日：1999-06-11

    Applicant: Lothar Lilge ,  David Walsh

    Inventor： Lothar Lilge ,  David Walsh

    IPC: A61B1822

    CPC classification number: G01N21/7703 ,  A61N5/0601 ,  A61N5/062 ,  G01N21/6428 ,  G01N2201/0846 ,  G01N2201/088

    Abstract: A multitasking optical fiber probe for collecting dosimeter information from more than one position in a sample. The basic principle of the present invention involves using one or more different sensor zones along the length of the fiber each with a different photoactive constituent having a sufficiently unique emission spectra (spectral or temporal) to enable deconvolution of the emission spectra by the computer and therefore correlation of the detected parameter with the position of the sensor zone along the length of the optical fiber. In the broadest form of the invention the probe is embodied by only one sensor zone located at some point along the length of the fiber spaced away from the end face of the fiber. Probes are provided in which multiple sensor zones are disposed along the length of the fiber and photoactive constituents with sufficiently unique emission spectra (intensity and/or spectral shape which convey the optical information) are used in the different sensor zones so that the different spectra can be deconvoluted so that the contributions from the various etch zones can be distinguished. More than one different photoactive constituent could be incorporated into a single sensor zone for measuring several factors in the vicinity of the sensor zone. In photodynamic therapy applications the probe is isotropic in response and can be employed for all light (300 to 900nm) based medical diagnostics and therapeutics. As an extension the probe can include photosensitiser and molecular oxygen concentrations dosimetry to be used for photodynamic therapy (PDT) treatment monitoring, dosimetry and planning utilizing a mathematical model describing tissue response to PDT.

    Abstract translation: 一种用于从样品中多于一个位置收集剂量计信息的多任务光纤探针。 本发明的基本原理涉及沿着纤维的长度使用一个或多个不同的传感器区域，每个具有不同的光活性组分具有足够独特的发射光谱（光谱或时间），以使计算机能够对发射光谱进行去卷积，因此 检测参数与传感器区域沿着光纤长度的位置的相关性。 在本发明的最广泛形式中，探针仅通过位于沿纤维长度的某一点处的一个传感器区域，该距离与纤维的端面间隔开。 提供探针，其中多个传感器区域沿着纤维的长度设置，并且光​​活性组分具有足够独特的发射光谱（传递光学信息的强度和/或光谱形状）被用于不同的传感器区域，使得不同的光谱可以 被去卷积，从而可以区分来自各种蚀刻区域的贡献。 可以将多于一种不同的光活性成分结合到单个传感器区域中，以测量传感器区域附近的几个因素。 在光动力学治疗应用中，探针是各向同性的响应，可用于所有基于光（300至900nm）的医疗诊断和治疗。 作为延伸，探针可以包括用于光动力治疗（PDT）治疗监测，剂量测定和计划的光敏剂和分子氧浓度剂量学，其使用描述对PDT的组织反应的数学模型。

    Chemical analyzer optical probe and method of manufacturing same
    118.
    发明授权
    Chemical analyzer optical probe and method of manufacturing same 失效
    化学分析仪光学探针及其制造方法

    公开(公告)号：US06244753B1

    公开(公告)日：2001-06-12

    申请号：US09038350

    申请日：1998-03-11

    Applicant: Eamon O'Connor ,  John M. Jarvis ,  John J. O'Donnell

    Inventor： Eamon O'Connor ,  John M. Jarvis ,  John J. O'Donnell

    IPC: G02B600

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0846 ,  G02B6/325 ,  G02B6/3826 ,  G02B6/3846 ,  G02B6/3878

    Abstract: An instrument that analyzes chemical properties of a specimen includes a probe that is used in place on the specimen for spectroscopic analysis. The probe has a probe body with a proximal end and a distal end, and a first optical fiber extends from the proximal to the distal ends. A temperature sensor is included in the probe body and is used so insure that the probe does not exceed a rated temperature limit or to monitor specimen temperature while, simultaneously, chemical composition information of the specimen is transmitted by the optical fiber. The probe can be inserted into a container holding the specimen and can yield both temperature and chemical composition information. The probe includes a plurality of metal coated fibers with the distal ends of the fibers positioned inside a bore in the probe. Braze material is placed on the probe near the bore and the braze material is then brazed to the metal coating on the ends of the fiber.

    Abstract translation: 分析试样的化学性质的仪器包括在样品上用于光谱分析的探针。 该探头具有一个具有近端和远端的探针主体，并且第一光纤从近端延伸到远端。 温度传感器包含在探针体内，用于确保探针不超过额定温度极限或监测样品温度，同时，通过光纤传输试样的化学成分信息。 探针可以插入容纳样品的容器中，并可以产生温度和化学成分信息。 探针包括多个金属涂覆的纤维，其中纤维的末端位于探针中的孔内。 将钎焊材料放置在孔附近的探针上，然后钎焊材料钎焊到纤维端部的金属涂层上。

Patent Agency Ranking