公开(公告)号：US20130021602A1

公开(公告)日：2013-01-24

申请号：US13412564

申请日：2012-03-05

Applicant: Vladimir Dribinski ,  Yung-Ho Alex Chuang ,  J. Joseph Armstrong ,  John Fielden

Inventor： Vladimir Dribinski ,  Yung-Ho Alex Chuang ,  J. Joseph Armstrong ,  John Fielden

IPC: G01N21/94 ,  C03B25/00 ,  G01N21/88 ,  H01S3/098 ,  G02F1/35

CPC classification number: H01S5/0092 ,  C03B33/02 ,  C30B1/02 ,  C30B29/10 ,  C30B29/14 ,  C30B29/22 ,  C30B29/30 ,  C30B33/02 ,  G01N21/88 ,  G01N21/8806 ,  G01N21/94 ,  G01N21/9501 ,  G01N2201/06113 ,  G01N2201/0637 ,  G01N2201/068 ,  G02F1/353 ,  G02F1/3551 ,  G02F1/3553 ,  G02F1/37 ,  G02F2001/3505 ,  G02F2001/3507 ,  G02F2001/354 ,  G02F2202/20 ,  H01S3/0092 ,  H01S3/10 ,  H01S3/10038 ,  H01S3/10046 ,  H01S3/11

Abstract: A mode-locked laser system operable at low temperature can include an annealed, frequency-conversion crystal and a housing to maintain an annealed condition of the crystal during standard operation at the low temperature. In one embodiment, the crystal can have an increased length. First beam shaping optics can be configured to focus a beam from a light source to an elliptical cross section at a beam waist located in or proximate to the crystal. A harmonic separation block can divide an output from the crystal into beams of different frequencies separated in space. In one embodiment, the mode-locked laser system can further include second beam shaping optics configured to convert an elliptical cross section of the desired frequency beam into a beam with a desired aspect ratio, such as a circular cross section.

Abstract translation: 可在低温下操作的模式锁定激光系统可以包括退火的频率转换晶体和壳体，以在低温下的标准操作期间保持晶体的退火状态。 在一个实施例中，晶体可以具有增加的长度。 第一光束整形光学元件可以被配置成将来自光源的光束聚焦到位于或接近晶体的光束腰部处的椭圆形横截面。 谐波分离块可以将来自晶体的输出分成在空间中分离的不同频率的波束。 在一个实施例中，锁模激光系统还可以包括第二光束整形光学器件，其被配置为将期望的频率波束的椭圆形横截面转换成具有期望的纵横比的光束，例如圆形横截面。

公开(公告)号：US20120143142A1

公开(公告)日：2012-06-07

申请号：US13299433

申请日：2011-11-18

Applicant: Kees Cornelis Klein

Inventor： Kees Cornelis Klein

IPC: A61M5/31

CPC classification number: G01N21/01 ,  A61M5/1412 ,  A61M5/31 ,  A61M5/3129 ,  A61M2209/02 ,  G01N21/11 ,  G01N2201/068

Abstract: The present invention relates to a syringe (1) for use in spectroscopy to identify drugs within the syringe (8). The syringe comprises a optical window section (8) either integral with or attached to the syringe (1). The optical window section (8) has predetermined physical and optical properties that allows radiation to pass through in a known manner to facilitate spectroscopy.

Abstract translation: 本发明涉及一种用于光谱学鉴定注射器（8）内的药物的注射器（1）。 注射器包括与注射器（1）成一体或附着于注射器（1）的光学窗口部分（8）。 光学窗口部分（8）具有预定的物理和光学特性，其允许辐射以已知的方式通过以促进光谱。

公开(公告)号：US20120021525A1

公开(公告)日：2012-01-26

申请号：US13031146

申请日：2011-02-18

Applicant: Adrian FEHR ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

Inventor： Adrian FEHR ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

IPC: G01N21/64 ,  H01L27/144 ,  G01J3/50

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

Abstract translation: 提供光学收集和检测系统，用于随着时间的推移从光源阵列测量光信号。 还描述了使用光学器件收集和检测系统的方法。

公开(公告)号：US20120019828A1

公开(公告)日：2012-01-26

申请号：US13031122

申请日：2011-02-18

Applicant: Nathaniel Joseph McCAFFREY ,  Stephen Turner ,  Ravi Saxena ,  Scott Edward Helgesen

Inventor： Nathaniel Joseph McCAFFREY ,  Stephen Turner ,  Ravi Saxena ,  Scott Edward Helgesen

IPC: G01N21/00 ,  H01R12/70 ,  G02B6/02

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.

Abstract translation: 用于集成到分析系统中的统一设备结构内的分析组件。 分析组件是可扩展的，并且包括多个分析装置，每个分析装置包括反应池，光学传感器和定位成与反应池和传感器两者光学通信的至少一个光学元件， 电池到传感器。 额外的元件可选地集成到分析组件中。 还公开了形成和操作分析系统的方法。

公开(公告)号：US20110172523A1

公开(公告)日：2011-07-14

申请号：US12245538

申请日：2008-10-03

Applicant: Michael J. Natan ,  William E. Doering

Inventor： Michael J. Natan ,  William E. Doering

IPC: A61B6/00 ,  B82Y5/00

CPC classification number: B22F9/14 ,  B22F1/0025 ,  B22F2001/0037 ,  B22F2998/00 ,  B82Y30/00 ,  C25D1/006 ,  C25D1/04 ,  G01N21/658 ,  G01N33/54346 ,  G01N2201/06113 ,  G01N2201/068 ,  Y10T436/13 ,  B22F1/0018 ,  B22F1/025 ,  B22F1/02

Abstract: Submicron-sized particles or labels that can be covalently or non-covalently affixed to entities of interest for the purpose of quantification, location, identification, tracking, and diagnosis, are described.

Abstract translation: 描述了可以共价或非共价附着到感兴趣实体以进行定量，定位，鉴定，跟踪和诊断的亚微米尺寸的颗粒或标签。

公开(公告)号：US20100291667A1

公开(公告)日：2010-11-18

申请号：US12775044

申请日：2010-05-06

Applicant: Yuji Segawa ,  Tasuku Yotoriyama ,  Shinichi Kai

Inventor： Yuji Segawa ,  Tasuku Yotoriyama ,  Shinichi Kai

IPC: C12Q1/68

CPC classification number: G01N21/6454 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N21/6428 ,  G01N2201/068

Abstract: Disclosed herein is an optical detector at least including: a first substrate in which a plurality of wells are formed; a second substrate in which a heating section is provided to heat the wells; a third substrate in which a plurality of photoirradiation sections are provided in alignment with the wells; and a fourth substrate in which a plurality of photodetection sections are provided in alignment with the wells.

Abstract translation: 本文公开了一种光学检测器，至少包括：第一基板，其中形成有多个孔; 第二基板，其中设置加热部分以加热所述孔; 第三基板，其中设置有与所述孔对准的多个光照射部分; 以及第四基板，其中设置有与所述孔对准的多个光电检测部。

公开(公告)号：US20100261208A1

公开(公告)日：2010-10-14

申请号：US12740068

申请日：2008-10-29

Applicant: Volkmar Schollhorn

Inventor： Volkmar Schollhorn

IPC: G01N33/53

CPC classification number: G01N33/56972 ,  G01N21/6428 ,  G01N33/50 ,  G01N33/5091 ,  G01N33/53 ,  G01N33/569 ,  G01N2021/6439 ,  G01N2201/068 ,  G01N2333/55 ,  G01N2333/57 ,  G01N2800/26 ,  G01N2800/52

Abstract: An ELISPOT method for in vitro diagnosis and/or in vitro therapy monitoring of infections and/or infectious diseases comprising incubating eukaryotic cells with an antigen, measuring the number of immunocompetent cells which secrete at least two different cytokines as a reaction to the antigen, and in measuring the immunocompetent cells, visualizing the cells with the aid of at least two different dyes and at least two different filter sets, the filter sets comprising narrowband filters.

Abstract translation: 用于体外诊断和/或体外治疗感染和/或感染性疾病监测的ELISPOT方法，包括用抗原孵育真核细胞，测量分泌至少两种不同细胞因子作为与抗原的反应的免疫活性细胞的数量，以及 在测量免疫活性细胞中，借助于至少两种不同的染料和至少两种不同的过滤器组来显现细胞，所述过滤器组包括窄带过滤器。

公开(公告)号：US20100249547A1

公开(公告)日：2010-09-30

申请号：US12815372

申请日：2010-06-14

Applicant: James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/15

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US20080137074A1

公开(公告)日：2008-06-12

申请号：US11944684

申请日：2007-11-26

Applicant: Dov Furman ,  Roy Kaner ,  Ori Gonen ,  Daniel Mandelik ,  Eran Tal ,  Shai Silberstein

Inventor： Dov Furman ,  Roy Kaner ,  Ori Gonen ,  Daniel Mandelik ,  Eran Tal ,  Shai Silberstein

IPC: G01N21/00 ,  G01J4/00

CPC classification number: G01N21/95607 ,  G01N21/21 ,  G01N2021/95615 ,  G01N2201/068

Abstract: In an optical inspection tool, an image of an object under inspection, such as a semiconductor wafer, may be obtained using imaging optics defining a focal plane. Light comprising the image can be split into portions that are detected using multiple detectors which each register a portion of the image. The image of the object at the focal plane can be split into two, three, or more parts by polarization-based beam splitters and/or lenses positioned tangent to the focal plane. The splitting apparatus may comprise a pair of arrays of half-cylinder lenses comprising a convex side and a flat side. The arrays can be positioned with the cylinder axes perpendicular to one another and the flat sides facing each other. Thus, the pair of arrays can divide incoming light into a plurality of rectangular portions without introducing non-uniformities which would occur if several spherical lenses are configured for use in a rectangular array.

Abstract translation: 在光学检查工具中，可以使用限定焦平面的成像光学元件来获得被检查物体（诸如半导体晶片）的图像。 包括图像的光可以被分割成使用多个检测器检测的部分，每个检测器记录图像的一部分。 在焦平面处的物体的图像可以通过基于偏振的分束器和/或与焦平面相切的透镜分离成两个，三个或更多个部分。 分割装置可以包括一对半柱透镜，其包括凸面和平坦侧。 阵列可以被定位成使得圆柱轴线彼此垂直并且平坦的面朝向彼此。 因此，一对阵列可以将入射光分成多个矩形部分，而不会引入不均匀性，如果若干球形透镜配置为用于矩形阵列，则会发生不均匀性。

公开(公告)号：US20070238161A1

公开(公告)日：2007-10-11

申请号：US11804151

申请日：2007-05-17

Applicant: Anthony Cerrone ,  Edward Lakatos ,  Michael Gambini ,  Eugene Young ,  Susan Stone ,  Judith Atwood

Inventor： Anthony Cerrone ,  Edward Lakatos ,  Michael Gambini ,  Eugene Young ,  Susan Stone ,  Judith Atwood

IPC: C12M1/34 ,  C12M1/36

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.