公开(公告)号：US08620397B2

公开(公告)日：2013-12-31

申请号：US12573821

申请日：2009-10-05

Applicant: Bernhard B. Sterling ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Bernhard B. Sterling ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/1455 ,  G01N21/00

CPC classification number: G01N21/274 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1495 ,  A61B2560/0223 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/35 ,  G01N35/00693 ,  G01N35/00712 ,  G01N2201/1215 ,  G01N2201/127

Abstract: A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

Abstract translation: 描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。 该方法减少了在存在干扰物的情况下分析物浓度的误差。 该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。 从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

公开(公告)号：US20130168327A1

公开(公告)日：2013-07-04

申请号：US13713629

申请日：2012-12-13

Applicant: STEP AHEAD INNOVATIONS, INC.

Inventor： James E. Clark

IPC: C02F1/00

CPC classification number: G01N21/77 ,  A01K63/04 ,  C02F1/008 ,  C02F2103/42 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/008 ,  C02F2209/06 ,  C02F2209/14 ,  C02F2209/15 ,  C02F2209/18 ,  G01N21/15 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8507 ,  G01N21/88 ,  G01N31/22 ,  G01N33/18 ,  G01N2021/758 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/127 ,  G02B6/0001 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/175383 ,  Y10T436/193333 ,  Y10T436/207497 ,  Y10T436/25 ,  Y10T436/25375

Abstract: An aquatic environment monitoring system and method that includes correction for adverse conditions in the monitoring system involving the development of confidence levels for certain conditions in the monitoring system using stored information related to the aquatic environment and/or the monitoring system. Corrections to adverse conditions may be made by the environment monitoring system automatically by the monitoring system and manually via communications to a user of the system.

Abstract translation: 一种水环境监测系统和方法，其包括使用与水生环境和/或监测系统相关的存储信息来监测监测系统中的不利条件，以改善监测系统中某些条件的置信水平。 环境监测系统可能会由监控系统自动进行恶劣环境的修正，并通过与系统用户的通信手动进行。

公开(公告)号：US20130126757A1

公开(公告)日：2013-05-23

申请号：US13650938

申请日：2012-10-12

Applicant: Affymetrix, Inc.

Inventor： Bei-Shen Sywe ,  Mark Borodkin ,  Chuan Gao ,  Liana Ilkova ,  Devin Nguyen

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N21/278 ,  G01N21/64 ,  G01N2201/127

Abstract: Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them. Specifically, disclosed are calibration apparatuses with a fluorescent layer, such as photoresist, deposited on a substrate, with an optional layer of a reflective material, such as chrome. Illumination of the fluorescent and/or reflective layers, and detection and analysis of the resulting emissions allows evaluation of the instrument with respect to both reflective and fluorescent channels. Selection of appropriate fluorescent materials for the one or more fluorescent layers allows the evaluation of an instrument with respect to different fluorophores, as would be used with an instrument capable of two color detection. Inclusion of a reflective layer further allows the evaluation and calibration of all optical channels of an instrument, including the reflective channel and two or more fluorescent channels, with a single calibration apparatus for imaging criteria such as uniformity, contrast and emission signal strength.

Abstract translation: 公开了用于荧光显微镜仪器的校准装置及其制造和使用方法。 具体地，公开了具有沉积在基板上的诸如光致抗蚀剂的荧光层的校准装置，其中具有诸如铬的反射材料的任选层。 荧光和/或反射层的照明以及所得到的辐射的检测和分析允许对于反射和荧光通道评估仪器。 为一个或多个荧光层选择合适的荧光材料允许相对于不同荧光团的仪器的评估，这将与能够进行两种颜色检测的仪器一起使用。 包括反射层还允许使用单个校准装置评估和校准包括反射通道和两个或更多个荧光通道的仪器的所有光通道，用于诸如均匀性，对比度和发射信号强度的成像标准。

公开(公告)号：US08008610B2

公开(公告)日：2011-08-30

申请号：US12318127

申请日：2008-12-22

Applicant: Hidemitsu Asano ,  Sadayuki Matsumiya

Inventor： Hidemitsu Asano ,  Sadayuki Matsumiya

IPC: G01J1/32

CPC classification number: G01B11/24 ,  G01N2201/127

Abstract: An image measuring instrument includes a camera that images a plurality of measured points based on a preset measuring procedure, and an illumination unit that irradiates the measured points. The image measuring instrument measures a dimension and a shape of a to-be-measured object while the illumination unit irradiates light having illumination light quantity corresponding to an illumination preset value with reference to the illumination preset value that is preliminarily set for every measured point. An illumination light quantity setting method includes a command signal output step that outputs a command signal for irradiating light having the illumination light quantity corresponding to the illumination preset value for every measured point, an offset value assigning step that assigns an offset value to the command signal to be sent to the illumination unit, and a setting step that sets the offset value to be variable.

Abstract translation: 图像测量仪器包括基于预设测量程序对多个测量点进行成像的照相机和照射测量点的照明单元。 图像测量装置在照射单元照射预先设定为每个测量点的照明预设值的情况下照射具有与照明预设值相对应的照明光量的光时，测量待测物体的尺寸和形状。 照明光量设定方法包括：命令信号输出步骤，输出用于照射具有与每个测量点对应的照明预设值的照明光量的光的命令信号;偏移值分配步骤，向所述命令信号分配偏移值 被发送到照明单元，以及将偏移值设定为可变的设定步骤。

公开(公告)号：US20110181879A1

公开(公告)日：2011-07-28

申请号：US13003464

申请日：2009-07-01

Applicant: Jia Chen ,  Andreas Hangauer ,  Rainer Strzoda

Inventor： Jia Chen ,  Andreas Hangauer ,  Rainer Strzoda

IPC: G01N21/39

CPC classification number: G01N21/39 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/399 ,  G01N2201/127

Abstract: A method and a sensor for detecting a target gas by laser spectroscopy using a laser or a laser diode having a monochrome emission wavelength that can be modulated by varying the operating temperature or the operating current. The wavelength range of the target gas comprises a first modulation of the laser or the laser diode over a first large modulation width, in addition to at least two absorption lines of a reference gas and at least one absorption line of the target gas. The absorption lines are used to calibrate the wavelength scale of the laser or the laser diode in relation to the varied operating temperature or operating current, a second modulation of the laser or the laser diode being performed over a second small modulation width, with the at least one absorption line of the target gas, for detecting the target gas.

Abstract translation: 一种通过激光光谱法使用具有可通过改变工作温度或工作电流进行调制的具有单色发射波长的激光或激光二极管来检测目标气体的方法和传感器。 目标气体的波长范围除了基准气体的至少两条吸收线和目标气体的至少一条吸收线之外，包括在第一大调制宽度上的激光或激光二极管的第一调制。 吸收线用于相对于变化的工作温度或工作电流来校准激光器或激光二极管的波长标度，激光器或激光二极管的第二调制在第二小调制宽度上执行，其中at 目标气体的至少一个吸收线，用于检测目标气体。

公开(公告)号：US20100312483A1

公开(公告)日：2010-12-09

申请号：US12794466

申请日：2010-06-04

Applicant: THOMAS A. PEYSER ,  SOYA GAMSEY ,  MATTHEW A. ROMEY ,  DAVID R. MARKLE

Inventor： THOMAS A. PEYSER ,  SOYA GAMSEY ,  MATTHEW A. ROMEY ,  DAVID R. MARKLE

IPC: G06F19/00 ,  G01N33/48

CPC classification number: G01N33/66 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/6428 ,  G01N21/6486 ,  G01N31/22 ,  G01N33/52 ,  G01N33/582 ,  G01N2021/6432 ,  G01N2201/062 ,  G01N2201/127

Abstract: Disclosed are embodiments that relate to algorithms and methods for calibrating an analyte sensor, and more particularly, to algorithms for calibrating an optical glucose sensor comprising an equilibrium fluorescent chemical indicator system. In particular, a method of detecting an analyte concentration is disclosed where a modified Michaelis-Menten equation comprising Michaelis-Menten parameters is used to characterize the signal generated by the analyte sensor.

Abstract translation: 公开了涉及用于校准分析物传感器的算法和方法的实施例，更具体地，涉及用于校准包括平衡荧光化学指示器系统的光学葡萄糖传感器的算法。 特别地，公开了一种检测分析物浓度的方法，其中使用包含Michaelis-Menten参数的修改的Michaelis-Menten方程表征由分析物传感器产生的信号。

公开(公告)号：US07385701B2

公开(公告)日：2008-06-10

申请号：US11287329

申请日：2005-11-23

Applicant: Koji Watanabe ,  Norio Ishikawa ,  Masao Nakamuro

Inventor： Koji Watanabe ,  Norio Ishikawa ,  Masao Nakamuro

IPC: G01J3/46

CPC classification number: G01N21/251 ,  G01J3/0264 ,  G01J3/0267 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/50 ,  G01J3/524 ,  G01N21/276 ,  G01N2201/127 ,  G01N2201/12723 ,  G01N2201/12738 ,  G01N2201/128

Abstract: A standard plane sample which supplies an optical characteristic measuring device with reference data. The standard plane sample including a sample portion that is measured by the optical characteristic measuring device to supply measurement data, and a recording medium that stores identification data for identifying a kind of the sample portion as well as reference data corresponding to the optical characteristic of the sample portion.

Abstract translation: 一种标准平面样品，其提供具有参考数据的光学特性测量装置。 包括由光学特性测量装置测量的用于提供测量数据的样本部分的标准平面样本以及存储用于识别样本部分的种类的识别数据的记录介质以及对应于样本部分的光学特性的参考数据 样品部分。

公开(公告)号：US07359815B2

公开(公告)日：2008-04-15

申请号：US11358697

申请日：2006-02-21

Applicant: Martin Pirzer ,  Jürgen Sawatzki

Inventor： Martin Pirzer ,  Jürgen Sawatzki

IPC: G06F15/00

CPC classification number: G01J3/44 ,  G01J3/28 ,  G01J2003/4424 ,  G01N21/274 ,  G01N21/65 ,  G01N2201/127

Abstract: A method is provided for correcting at least one portion of a spectrum, in particular a Raman spectrum, by eliminating a baseline which is due to a perturbing spectrum, in particular due to a fluorescence spectrum, superimposed on the spectrum, wherein i) a convex envelope of the spectrum is determined, at least in the portion of the spectrum which is to be corrected, and ii) the convex part of the envelope lying below the spectrum is subtracted from the spectrum in the portion to be corrected. Before step i), iii) a convex function f is added to the spectrum in the portion to be corrected.

Abstract translation: 提供了一种用于通过消除由于扰动光谱引起的基线，特别是由于叠加在光谱上的荧光光谱而校正光谱的至少一部分，特别是拉曼光谱的方法，其中i）凸起 至少在待校正的光谱部分中确定光谱的包络，以及ii）从待校正部分的光谱中减去位于光谱之下的包层的凸部。 在步骤i）之前，iii）在要校正的部分中的光谱中加入凸函数f。

公开(公告)号：US20070030482A1

公开(公告)日：2007-02-08

申请号：US11199836

申请日：2005-08-08

Applicant: Zhenghua Ji ,  Dianne Rees

Inventor： Zhenghua Ji ,  Dianne Rees

IPC: G01J3/42

CPC classification number: G01J3/42 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0278 ,  G01N21/0303 ,  G01N21/31 ,  G01N2021/0396 ,  G01N2201/127

Abstract: A spectrophotometer used to analyzing a sample. The spectrophotometer comprises a light source and a detector. An optical assembly defines at least one light path, the light path arranged to carry light from the light source through a sample, and received by the detector, wherein a pathlength of the light through the sample is varied by adjusting an angle of incidence of the light through the sample.

Abstract translation: 用于分析样品的分光光度计。 分光光度计包括光源和检测器。 光学组件限定至少一个光路，所述光路被布置成携带来自光源的光通过样品并被检测器接收，其中通过样品的光的路径长度通过调整入射角来改变 光通过样品。

公开(公告)号：US20060279725A1

公开(公告)日：2006-12-14

申请号：US11438722

申请日：2006-05-22

Applicant: William Coville ,  Donald Ware

Inventor： William Coville ,  Donald Ware

IPC: G01N33/48 ,  G01N21/59

CPC classification number: G01N21/59 ,  G01N21/33 ,  G01N2021/825 ,  G01N2201/062 ,  G01N2201/127

Abstract: An aggregometer has a radiation path along which radiation can pass, a sample receiving area located along the radiation path, a short-wavelength LED that transmits radiation along the radiation path through the sample receiving area, a detector positioned along the radiation path for detecting radiation transmitted from the short-wavelength LED, and a processor that controls intensity of radiation transmitted from the short-wavelength LED.

Abstract translation: 聚光计具有辐射可以通过的辐射路径，沿着辐射路径定位的样本接收区域，沿着辐射路径透射通过样本接收区域的辐射的短波长LED，沿着辐射路径定位的检测辐射的检测器 从短波长LED发送的处理器和控制从短波长LED发射的辐射强度的处理器。