公开(公告)号：US20140364330A1

公开(公告)日：2014-12-11

申请号：US14299445

申请日：2014-06-09

Applicant: Massachusetts Institute of Technology

Inventor： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

IPC: G01N21/55

CPC classification number: G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

Abstract: The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

Abstract translation: 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

公开(公告)号：US20140356132A1

公开(公告)日：2014-12-04

申请号：US13888715

申请日：2013-05-07

Applicant: SNECMA

Inventor： Andre LEROUX ,  Serge Del Arco ,  Olivier Follerot ,  Michel Herbault ,  Philippe Armand Hugbart ,  Fabien Pouchard ,  Etienne Tulie

IPC: G01M15/14 ,  G01N21/17 ,  F01D21/00

CPC classification number: G01M15/14 ,  F01D21/003 ,  G01B11/14 ,  G01H1/006 ,  G01H9/006 ,  G01M7/00 ,  G01N21/1702 ,  G01N2021/1706 ,  G01N2201/08

Abstract: The invention relates to a device for measuring vibration amplitudes of the blade tips in a turbomachine, comprising a support mounted in an orifice of a casing of a turbomachine and wherein are housed two optical guides for the emission and reception of a light signal exiting inside the casing across from the tips of the blades of a turbine wheel. Each optical guide comprises an optical fibre connected by a mechanical connector to a needle of which the core is made of a material able to transmit a light signal and which is resistant to temperatures less than or equal to 1100° C. and which exits at its distal end in the casing across from the blade tips.

Abstract translation: 本发明涉及一种用于测量涡轮机中的叶片尖端的振幅的装置，包括安装在涡轮机壳体的孔口中的支撑件，并且其中容纳有两个光导件，用于发射和接收从内部 从涡轮机叶片的叶片的尖端穿过。 每个光学引导件包括通过机械连接器连接到针的光纤，芯的芯由能够传输光信号的材料制成，并且其耐受低于或等于1100℃的温度，并且在其出口处 外壳中的远端从刀片尖端穿过。

公开(公告)号：US20140347472A1

公开(公告)日：2014-11-27

申请号：US14131035

申请日：2012-07-09

Applicant: Michael A. Davis ,  Andrew E. Carlson ,  David O. Winkowski ,  John V. Viega ,  Alan D. Kersey ,  Mark R. Fernald

Inventor： Michael A. Davis ,  Andrew E. Carlson ,  David O. Winkowski ,  John V. Viega ,  Alan D. Kersey ,  Mark R. Fernald

IPC: G01N21/27 ,  H04N5/33 ,  G01N21/31 ,  G06T7/00 ,  G01N21/84 ,  G01G19/08

CPC classification number: G01N21/27 ,  G01G19/08 ,  G01N21/31 ,  G01N21/3563 ,  G01N21/84 ,  G01N33/241 ,  G01N2201/025 ,  G01N2201/08 ,  G01N2201/12 ,  G06T7/00 ,  G06T2207/30181 ,  H04N5/332

Abstract: Apparatus is provided featuring a signal processor or signal processing module configured to receive signaling containing information about images of an ore sample; and determine information about a Bitumen Content of the ore sample based at least partly on the signaling, including for use in real time ore blend management in a bitumen recovery process related to mined oil sands. The ore sample may be an ore face, and the signaling may contain information about the images of the ore face. The signal processor or signal processing module may be configured to determine a real time ore face ore grade visualization based at least partly on the signaling, and provide corresponding signaling containing information about the real time ore face ore grade visualization, including a composite overlay image.

Abstract translation: 提供设备，其特征在于信号处理器或信号处理模块，其被配置为接收包含关于矿石样品的图像的信息的信令; 并且至少部分地基于信号确定矿石样品的沥青含量的信息，包括用于与开采的油砂相关的沥青回收过程中的实时矿石混合管理。 矿石样品可以是矿石面，信号可以包含关于矿石图像的信息。 信号处理器或信号处理模块可以被配置为至少部分地基于信令来确定实时矿石等级可视化，并且提供包含关于实时矿石等级可视化的信息的相应信令，包括复合覆盖图像。

公开(公告)号：US08888498B2

公开(公告)日：2014-11-18

申请号：US12792073

申请日：2010-06-02

Applicant: Charles-Etienne Bisaillon ,  Guy Lamouche ,  Marc L. Dufour

Inventor： Charles-Etienne Bisaillon ,  Guy Lamouche ,  Marc L. Dufour

IPC: G09B23/30 ,  G09B23/28 ,  A61B5/00

CPC classification number: G01N21/4785 ,  A61B5/00 ,  A61B2560/0228 ,  A61B2560/0233 ,  G01N21/59 ,  G01N2201/08 ,  G01N2201/127 ,  G09B23/285 ,  G09B23/286

Abstract: A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer. The supporting element supports the material in 2 or 3 directions and effectively molds a lumen of the tissue. The neighboring layers are of different composition and of chosen thickness to provide desired optical properties and mechanical properties of the phantom. The phantom may have selected attenuation and backscattering properties to mimic tissues for optical coherence tomography imaging.

Abstract translation: 用于制造多层组织体模的方法包括连续地形成至少两层，每层通过在支撑元件上沉积粘性可流动材料形成，或者由预先形成的由支撑元件支撑的体模层形成，选择性地重新分配材料，同时材料 正在凝固以控制该层的厚度分布，并允许该材料足够固化以施加下一层。 支撑元件以2或3个方向支撑材料，并有效地模制组织的内腔。 相邻的层具有不同的组成和选定的厚度以提供所需的光学性质和体模的机械性能。 幻影可以选择衰减和后向散射特性来模拟组织用于光学相干断层成像。

公开(公告)号：US20140273277A1

公开(公告)日：2014-09-18

申请号：US14215861

申请日：2014-03-17

Applicant: Hycor Biomedical, Inc.

Inventor： Ronald Norman Diamond ,  Steve Michael Gann ,  Eric Darnell Hall ,  Tae Ho Hwang ,  John Lewis Morton ,  Anatoly Moskalev ,  Bruce Alan Sargeant ,  Dennis Edwin Rieger ,  Marinela Gombosev ,  Mark David Van Cleve

IPC: G01N35/10 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/76 ,  G01N33/5306 ,  G01N33/54326 ,  G01N33/5434 ,  G01N33/54393 ,  G01N33/564 ,  G01N33/569 ,  G01N33/5695 ,  G01N33/56983 ,  G01N33/582 ,  G01N33/6854 ,  G01N33/6893 ,  G01N35/0098 ,  G01N35/1011 ,  G01N2021/6484 ,  G01N2035/0453 ,  G01N2035/1062 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2333/4703 ,  G01N2333/62 ,  G01N2333/78 ,  G01N2800/24 ,  Y10T436/119163

Abstract: An apparatus for measuring the luminescence and the fluorescence of a sample, comprising: a light tight optics box capable of receiving a pipette tip containing a sample; an optical sensor located within the optics box and capable of being disposed in both a luminescence reading position and a fluorescence reading position; an excitation light fiber optic bundle and a sample transmission fiber optic bundle; an excitation light assembly that projects excitation light onto a first terminus end of the excitation light fiber optic bundle; and an in-line filter located along the sample transmission fiber optic bundle.

Abstract translation: 一种用于测量样品的发光和荧光的装置，包括：能够接收含有样品的移液管尖端的不透光光学盒; 光学传感器位于光学盒内并且能够被布置在发光读取位置和荧光读取位置; 激发光纤光束和样品传输光纤束; 激发光组件，其将激发光投射到激发光纤光束的第一末端; 以及沿着样品传输光纤束定位的串联滤波器。

公开(公告)号：US08780347B2

公开(公告)日：2014-07-15

申请号：US13159225

申请日：2011-06-13

Applicant: Petros Kotidis ,  Erik Deutsch ,  Ninghui Zhu ,  Dan Cavicchio

Inventor： Petros Kotidis ,  Erik Deutsch ,  Ninghui Zhu ,  Dan Cavicchio

IPC: G01J4/00

CPC classification number: G01N21/39 ,  B82Y20/00 ,  G01J3/108 ,  G01J3/26 ,  G01J3/4338 ,  G01J3/45 ,  G01N21/272 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577 ,  G01N2021/1793 ,  G01N2021/399 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/068 ,  G01N2201/08 ,  G02B21/0028 ,  G02B21/008 ,  G02B21/06 ,  H01S5/0071 ,  H01S5/141 ,  H01S5/3401 ,  H01S5/3402 ,  H01S5/4012 ,  H01S5/4031

Abstract: A spectroscopy system comprising at least two laser modules, each of the laser modules including a laser cavity, a quantum cascade gain chip for amplifying light within the laser cavity, and a tuning element for controlling a wavelength of light generated by the modules. Combining optics are used to combine the light generated by the at least two laser modules into a single beam and a sample detector detects the single beam returning from a sample.

Abstract translation: 一种包括至少两个激光模块的光谱系统，每个激光模块包括激光腔，用于放大激光腔内的光的量子级联增益芯片，以及用于控制由模块产生的光的波长的调谐元件。 组合光学器件用于将由至少两个激光模块产生的光组合成单个光束，并且样品检测器检测从样品返回的单个光束。

公开(公告)号：US20140178861A1

公开(公告)日：2014-06-26

申请号：US14194437

申请日：2014-02-28

Applicant: Reuven DUER

Inventor： Reuven DUER

IPC: G01N21/64 ,  G01N33/543

CPC classification number: G01N33/54373 ,  B01L3/502715 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0819 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N33/56988 ,  G01N2021/6439 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/103 ,  G02B6/4226 ,  Y10T436/143333

Abstract: The invention provides methods and devices for generating optical pulses in one or more waveguides using a spatially scanning light source. A detection system, methods of use thereof and kits for detecting a biologically active analyte molecule are also provided. The system includes a scanning light source, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, a detector that is coupled to and in optical communication with the substrate, and means for spatially translating a light beam emitted from said scanning light source such that the light beam is coupled to and in optical communication with the waveguides of the substrate at some point along its scanning path. The use of a scanning light source allows the coupling of light into the waveguides of the substrate in a simple and cost-effective manner.

Abstract translation: 本发明提供了使用空间扫描光源在一个或多个波导中产生光脉冲的方法和装置。 还提供了检测系统，其使用方法和用于检测生物活性分析物分子的试剂盒。 该系统包括扫描光源，包括多个波导的基板和与基板的一个或多个波导光学通信的多个光学感测位置，耦合到基板并与光学连接的检测器，以及装置 用于空间地平移从所述扫描光源发射的光束，使得所述光束在沿其扫描路径的某点处耦合到所述衬底的波导并与所述衬底的波导光通信。 使用扫描光源允许以简单且成本有效的方式将光耦合到衬底的波导中。

公开(公告)号：US08748111B2

公开(公告)日：2014-06-10

申请号：US13015851

申请日：2011-01-28

Applicant: Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

Inventor： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

IPC: G01N33/53 ,  C07K2/00 ,  B82Y30/00 ,  G01N33/00 ,  G01N21/55

CPC classification number: G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

Abstract: The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

Abstract translation: 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

公开(公告)号：US20140054464A1

公开(公告)日：2014-02-27

申请号：US13971748

申请日：2013-08-20

Applicant: SABIC Innovative IP B.V.

Inventor： Derek Lake ,  Yusuf Sulub ,  Zhensheng Ding

IPC: B01J4/00 ,  G01N21/59

CPC classification number: B01D53/1493 ,  B01D53/1412 ,  B01D53/1456 ,  B01D53/346 ,  B01D53/40 ,  B01D2251/304 ,  B01J4/008 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/59 ,  G01N2201/08 ,  Y10T137/0324

Abstract: Disclosed herein are processes, apparatuses, and systems for monitoring and/or controlling caustic concentrations in caustic scrubbers. In various aspects, the processes, apparatuses, and systems comprise a real-time online method for measuring the concentration of caustic in process scrubbers wherein a probe is coupled to a spectrometer; collecting absorption data with wavelength range from about 1000 to about 2000 nm. In a further aspect, this technique tracks the use and recharge of caustic in process scrubbers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract translation: 本文公开了用于监测和/或控制苛性碱洗涤器中的苛性碱浓度的方法，装置和系统。 在各个方面，过程，设备和系统包括用于测量工艺洗涤器中苛性碱浓度的实时在线方法，其中探针耦合到光谱仪; 收集波长范围为约1000至约2000nm的吸收数据。 在另一方面，该技术跟踪工艺洗涤器中苛性碱的使用和再充电。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

公开(公告)号：US20140051083A1

公开(公告)日：2014-02-20

申请号：US13983508

申请日：2012-02-06

Applicant: Hideji Tajima

Inventor： Hideji Tajima

IPC: C12Q1/68

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L7/54 ,  B01L2300/1805 ,  C12Q1/6848 ,  G01N21/13 ,  G01N21/31 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/0098 ,  G01N35/10 ,  G01N35/1065 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/103 ,  G01N2035/1076 ,  G01N2201/08 ,  G01N2203/0226

Abstract: The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device provided on the mount and having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers via the measuring end; an on-mount measuring end transfer mechanism that makes the measuring end movable on the mount; and a measurement control portion that, following control of the mount transfer mechanism such that the coupling ends are simultaneously joined with the apertures of the reaction containers, controls the on-mount measuring end transfer mechanism such that the light guide portions of the coupling ends and the light guide portion of the measuring end are successively optically connected, and instructs a measurement by the measuring device.

Abstract translation: 本发明涉及一种自动响应/光测量装置及其方法，其目的是在不增加设备尺寸的情况下有效且快速地执行与高可靠性的反应有关的光学测量。 该装置被配置为具有：多个反应容器布置在其中的容器组; 测量座，其具有可与反应容器的孔连接的多个连接端，并具有与连接的反应容器的内部光学连接的导光部; 安装传送机构; 测量装置，其设置在所述安装件上并且具有测量端，所述测量端具有至少一个导光部分，所述至少一个导光部分可光学地连接到所述耦合端的导光部分，其能够经由所述反射容器内的光学状态接收基于所述光学状态的光 测量端 安装测量端传送机构，使得测量端能够在安装座上移动; 以及测量控制部分，其随着所述安装传送机构的控制使得所述联接端部与所述反应容器的孔同时连接，控制所述安装的测量端传送机构，使得所述联接器的导光部分终止;以及 测量端的导光部分依次光学连接，并指示测量装置的测量。