公开(公告)号：US10656157B2

公开(公告)日：2020-05-19

申请号：US14862517

申请日：2015-09-23

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang

IPC: G01N33/58 ,  H01J49/00 ,  G01N33/574 ,  G01N33/49

Abstract: The invention generally relates to methods for rare event detection using mass tags. In certain embodiments, the invention provides methods for detecting a target analyte in a sample that involve conducting an assay that specifically associates a mass tag with a target analyte in a sample, generating ions of the mass tag, and analyzing the generated ions of the mass tag, thereby detecting the target analyte from the sample.

公开(公告)号：US10559455B2

公开(公告)日：2020-02-11

申请号：US16516823

申请日：2019-07-19

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Depanjan Sarkar ,  Thalappil Pradeep ,  Rahul Narayanan

IPC: H01J49/16 ,  H01J49/04 ,  H05K1/18 ,  H01J49/00

Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.

公开(公告)号：US20200024762A1

公开(公告)日：2020-01-23

申请号：US16415531

申请日：2019-05-17

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Anyin Li ,  Thalappil Pradeep ,  Zane Baird

IPC: C25C7/06 ,  C25C7/00 ,  C25C1/22 ,  C25C1/20

Abstract: The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions.

公开(公告)号：US20200020516A1

公开(公告)日：2020-01-16

申请号：US16494973

申请日：2018-03-22

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks

IPC: H01J49/16 ,  H01J49/00

Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.

公开(公告)号：US10361073B2

公开(公告)日：2019-07-23

申请号：US15355501

申请日：2016-11-18

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: H01J49/04 ,  G01N27/62 ,  H01J49/00

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US20190128897A1

公开(公告)日：2019-05-02

申请号：US16071347

申请日：2017-01-20

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

IPC: G01N33/68 ,  G01N33/574

Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

公开(公告)号：US10204772B2

公开(公告)日：2019-02-12

申请号：US15902068

申请日：2018-02-22

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Ahmed Mohamed Hamid ,  Alan Keith Jarmusch ,  Zheng Ouyang

IPC: H01J49/04 ,  G01N27/62 ,  C12N13/00 ,  C12Q1/04 ,  H01J49/16

Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.

公开(公告)号：US20190006167A1

公开(公告)日：2019-01-03

申请号：US16103436

申请日：2018-08-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Pu Wei

IPC: H01J49/24 ,  H01J49/00 ,  H01J49/06 ,  H01J49/14 ,  G01N27/62

CPC classification number: H01J49/24 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/061 ,  H01J49/142

Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.

公开(公告)号：US20180372699A1

公开(公告)日：2018-12-27

申请号：US16107296

申请日：2018-08-21

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang

IPC: G01N30/95 ,  G01N33/49 ,  G01N30/91 ,  H01J49/16 ,  H01J49/04 ,  H01J49/00

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

公开(公告)号：US20180342382A1

公开(公告)日：2018-11-29

申请号：US15985188

申请日：2018-05-21

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/0036 ,  H01J49/0081 ,  H01J49/422 ,  H01J49/429

Abstract: The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.