公开(公告)号：US20140022546A1

公开(公告)日：2014-01-23

申请号：US14009444

申请日：2012-04-02

Applicant: Yoshiroh Nagai ,  Toshio Kawano

Inventor： Yoshiroh Nagai ,  Toshio Kawano

IPC: G01J3/45 ,  G06F17/14

CPC classification number: G01J3/45 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/4535 ,  G06F17/14

Abstract: A Fourier transform spectrometer (Da) of the invention extracts, in generating an integrated interferogram obtained by integrating a plurality of interferograms, an output of an interferometer (11a) within a predetermined range according to positioning information of a center burst in an interferogram measured at a time before measurement of an interferogram at the present time.

Abstract translation: 本发明的傅里叶变换光谱仪（Da）在根据中央突发的定位信息产生通过将多个干涉图积分的积分干涉图提取到预定范围内的干涉仪（11a）的输出， 在目前测量干涉图之前的时间。

公开(公告)号：US08593637B2

公开(公告)日：2013-11-26

申请号：US13583534

申请日：2012-04-26

Applicant: Jacob Riis Folkenberg ,  Hans Larsen

Inventor： Jacob Riis Folkenberg ,  Hans Larsen

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01J3/45 ,  G01J3/4535

Abstract: A spectrometric instrument comprising: a scanning interferometer having a beamsplitter for dividing incident optical radiation into a reflected beam, following a reflected beam path and a transmitted beam following a transmitted beam path; a monochromatic optical radiation source for launching a reference beam into the interferometer along a first propagation path to be initially incident on a first face of the beamsplitter; an observation optical radiation source for launching a divergent observation beam into the interferometer along a second propagation path to be initially incident on the first face of beamsplitter and overlap the reference beam at the first face; wherein the radiation sources cooperate to generate a first angle between the directions of propagation of the two beams along respective first and second propagation paths when initially and simultaneously incident at the first face which is larger than a divergence half-angle of the observation beam 64.

Abstract translation: 一种光谱仪，包括：扫描干涉仪，具有分束器，用于将入射光辐射分成反射光束，跟随反射光束路径和发射光束跟随传输光束路径; 用于沿着第一传播路径将参考光束发射到干涉仪中以最初入射在分束器的第一面上的单色光辐射源; 观测光辐射源，用于沿着第二传播路径将发散观测光束发射到干涉仪中，以最初入射到分束器的第一面上，并在第一面处与参考光束重叠; 其中所述辐射源在最初并且同时入射在大于所述观察光束64的发散半角的所述第一面时在所述两个光束沿着相应的第一和第二传播路径的传播方向之间产生第一角度。

公开(公告)号：US08593631B2

公开(公告)日：2013-11-26

申请号：US13275572

申请日：2011-10-18

Applicant: Hideaki Hirai ,  Masanori Kobayashi

Inventor： Hideaki Hirai ,  Masanori Kobayashi

IPC: G01J3/40 ,  G01J3/45 ,  G01B9/02

CPC classification number: G01J3/2823 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0259 ,  G02B5/1814 ,  G02B5/20

Abstract: A spectral image acquiring apparatus includes an optical filter on which light is incident; an image sensor including a two-dimensionally disposed pixel array for detecting the light via the optical filter; and a signal processing unit generating a difference-value image based on a detection signal from the image sensor. The optical filter includes a diffraction grating having a lattice pattern corresponding to one or more pixels on the image sensor. The signal processing unit calculates a difference value in an amount of received light between two adjacent pixels based on the detection signal from the image sensor, and generates the difference-value image based on the difference value. The difference value between the two adjacent pixels is varied depending on a difference in an interference point on the image sensor corresponding to a diffraction angle of the light that has passed through the diffraction grating.

Abstract translation: 光谱图像获取装置包括光入射的滤光器; 图像传感器，包括用于经由滤光器检测光的二维布置的像素阵列; 以及信号处理单元，其基于来自图像传感器的检测信号生成差值图像。 光学滤波器包括具有对应于图像传感器上的一个或多个像素的格子图案的衍射光栅。 信号处理单元基于来自图像传感器的检测信号计算两个相邻像素之间的接收光量的差值，并基于差值生成差值图像。 两个相邻像素之间的差值取决于对应于已经通过衍射光栅的光的衍射角的图像传感器上的干涉点的差异。

公开(公告)号：US08570524B2

公开(公告)日：2013-10-29

申请号：US12849046

申请日：2010-08-03

Applicant: Xiaoke Wan ,  Jian Ge

Inventor： Xiaoke Wan ,  Jian Ge

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01J3/02 ,  G01B9/02051 ,  G01J3/0259 ,  G01J3/28 ,  G01J3/45 ,  G01J3/4531 ,  G01J3/4532 ,  G01J2003/2866

Abstract: Calibration of an arbitrary spectrometer can use a stable monolithic interferometer as a wavelength calibration standard. Light from a polychromatic light source is input to the monolithic interferometer where it undergoes interference based on the optical path difference (OPD) of the interferometer. The resulting wavelength-modulated output beam is analyzed by a reference spectrometer to generate reference data. The output beam from the interferometer can be provided to an arbitrary spectral instrument. Wavelength calibration of the arbitrary spectral instrument may then be performed based on a comparison of the spectral instrument output with the reference data. By appropriate choice of materials for the monolithic interferometer, a highly stable structure can be fabricated that has a wide field and/or is thermally compensated. Because the interferometer is stable, the one-time generated reference data can be used over an extended period of time without re-characterization.

Abstract translation: 任意光谱仪的校准可以使用稳定的单片干涉仪作为波长校准标准。 来自多色光源的光被输入到单片干涉仪，其中它基于干涉仪的光程差（OPD）而受到干扰。 所得到的波长调制输出光束由参考光谱仪分析以产生参考数据。 来自干涉仪的输出光束可以提供给任意的光谱仪器。 然后可以基于光谱仪器输出与参考数据的比较来执行任意光谱仪器的波长校准。 通过适当地选择用于单片干涉仪的材料，可以制造具有宽场和/或热补偿的高度稳定的结构。 因为干涉仪是稳定的，所以一次性生成的参考数据可以在延长的时间段内被使用，而无需重新表征。

公开(公告)号：US20130265582A1

公开(公告)日：2013-10-10

申请号：US13868215

申请日：2013-04-23

Applicant: DUKE UNIVERSITY

Inventor： Adam Wax ,  John W. Pyhtila

IPC: G01J3/45

CPC classification number: A61B5/0084 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0075 ,  G01B9/02043 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01B9/02091 ,  G01J3/45 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

Abstract translation: 傅里叶域a / LCI（faLCI）系统和方法，使用单次扫描能够以快速的速率进行体内数据采集。 通过一次扫描获得角度分辨和深度解析的光谱信息。 由于仅需要一次扫描，参考臂可以相对于样品保持固定。 参考信号和反射的采样信号以相对于样本的多个反射角度相互相关并分散，从而同时并行地表示来自样品上的多个点的反射。 可以通过大约40毫秒量级的一次扫描获得关于样本上多个不同点的每个样本的所有深度的信息。 从空间相互关联的参考信号，也可以使用允许从角度分辨数据获得散射体的尺寸信息的技术来获得结构（尺寸）信息。

公开(公告)号：US20130215422A1

公开(公告)日：2013-08-22

申请号：US13735092

申请日：2013-01-07

Applicant: Hitachi, Ltd.

Inventor： Shigeharu KIMURA ,  Masataka SHIRAI ,  Koichi WATANABE

IPC: G01J3/45 ,  G01J3/44

CPC classification number: G01J3/45 ,  G01J3/44 ,  G01J3/453

Abstract: A signal is amplified by making a CARS beam from an observed body and a reference beam which is a portion of a super continuum beam and has a frequency of ωAS=2ωP−ωST interfere with each other and taking out the signal from an interference beam of the CARS beam and the reference beam.

Abstract translation: 通过从观测体进行CARS波束的信号和作为超连续波束的一部分且具有ωga= 2omega -P-ωgaST的频率的参考波束相互干扰并从干扰波束中取出信号来放大信号 CARS光束和参考光束。

公开(公告)号：US08422020B2

公开(公告)日：2013-04-16

申请号：US13617939

申请日：2012-09-14

Applicant: Hiroshi Wakai

Inventor： Hiroshi Wakai

IPC: G01B9/02 ,  G01J3/45 ,  G02B27/00

CPC classification number: G01B7/30 ,  G01B7/003 ,  G01J3/26

Abstract: The variable spectroscopic element includes a pair of optical substrates 21-22, four sensors 31-34, four piezoelectric elements 41-44, and a control section. The sensors 31, 33 are arranged to form symmetry with respect to the center axis, which links gravity centers of mutually facing surfaces of the optical substrates 21-22, and so are the sensors 32, 34. The control section calculates, from signals of the sensors 31-34, a distance x between the gravity centers of the mutually facing surfaces, and angles θ, φ each of which is formed by a plane perpendicular to the center axis and the facing surface of the movable substrate 22, to drive the piezoelectric elements 41-44 on the basis of the distance x, the angles θ, φ, and to carry out feedback control and feed forward control with respect to at least one of the distance x, the angle θ, and the angle φ.

Abstract translation: 可变分光元件包括一对光学基板21-22，四个传感器31-34，四个压电元件41-44和控制部分。 传感器31,33被布置成相对于连接光学基板21-22的相互面对的表面的重心的中心轴形成对称，传感器32,34也是这样。控制部分从 传感器31-34，相互面对的表面的重心之间的距离x和角度＆amp; 每个由垂直于中心轴的平面和可移动基板22的相对表面形成，以基于距离x，角度θ和角度θ来驱动压电元件41-44，并且承载 关于距离x，角度和角度以及角度＆phgr中的至少一个的反馈控制和前馈控制。

公开(公告)号：US08384907B2

公开(公告)日：2013-02-26

申请号：US12946635

申请日：2010-11-15

Applicant: Guillermo J. Tearney ,  Dvir Yelin ,  Brett E. Bouma

Inventor： Guillermo J. Tearney ,  Dvir Yelin ,  Brett E. Bouma

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01N33/4833 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6852 ,  G01B9/02 ,  G01B9/02027 ,  G01B9/02049 ,  G01B9/02064 ,  G01B9/02087 ,  G01B9/02091 ,  G01B9/04 ,  G01N21/25 ,  G01N21/27 ,  G01N21/4795 ,  G01N21/6458 ,  G01N21/6486 ,  G01N23/046 ,  G01N2021/1765 ,  G01N2223/419 ,  G02B21/0028 ,  G02B23/2423 ,  G02B23/243 ,  G02B23/2461 ,  G02B23/2476

Abstract: Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.

Abstract translation: 可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。 例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。 例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。 可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

公开(公告)号：US08351044B2

公开(公告)日：2013-01-08

申请号：US12729628

申请日：2010-03-23

Applicant: Shinya Matsumoto ,  Koki Morishita ,  Motohiro Mitamura

Inventor： Shinya Matsumoto ,  Koki Morishita ,  Motohiro Mitamura

IPC: G01J3/45

CPC classification number: G01J3/26 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/024 ,  G01J3/027 ,  G01J3/2823 ,  G01J3/36 ,  G01J2003/1213 ,  G01J2003/2866

Abstract: A spectral imaging apparatus includes: a spectral transmittance variable element having a spectral transmittance characteristics such that a transmittance periodically varies with wavelength and being capable of changing the variation period, for converting light from an object under observation into light having a plurality of peak wavelengths; a light extracting device for extracting, from the light having a plurality of peak wavelengths, light for imaging that contains a peak wavelength proximate to a predetermined command wavelength designated by a user and light for calibration that contains a peak wavelength other than the peak wavelength proximate to the command wavelength; an image sensor for capturing an image of the object under observation formed of the light for imaging; a detector for detecting, from the light for calibration, the peak wavelength other than the peak wavelength proximate to the command wavelength; and a control unit including, an operation processing section that calculates the peak wavelength that is proximate to the command wavelength and is contained in the light for imaging, from the peak wavelength that is other than the peak wavelength proximate to the command wavelength, is contained in the light for calibration and is detected by the detector, calculates an amount of shift between the peak wavelength proximate to the command wavelength as calculated and the command wavelength, and determines an amount of adjustment of the variation period on a basis of the amount of shift, and a drive processing section that drives the spectral transmittance variable element for changing the variation period.

Abstract translation: 一种光谱成像装置包括：具有分光透射率特性的光谱透射率可变元件，使得透射率周期性地随波长变化并且能够改变变化周期，用于将来自被观察物体的光转换成具有多个峰值波长的光; 一种光提取装置，用于从具有多个峰值波长的光中提取含有接近用户指定的预定指令波长的峰值波长的成像用光和用于校准的光，其包含峰值波长以外的峰值波长 指令波长; 用于捕获由用于成像的光形成的观察对象的图像的图像传感器; 用于从用于校准的光检测除了接近命令波长的峰值波长之外的峰值波长的检测器; 以及控制单元，包括：操作处理部，其从除了与命令波长相邻的峰值波长以外的峰值波长包含计算接近指令波长并且被包含在用于成像的光中的峰值波长的运算处理部， 在用于校准的光并由检测器检测的光中，计算接近所计算的命令波长的峰值波长与指令波长之间的偏移量，并且基于指示波长的量来确定变化周期的调整量 以及驱动处理部分，其驱动用于改变变化周期的光谱透射率可变元件。

公开(公告)号：US20120281899A1

公开(公告)日：2012-11-08

申请号：US13494303

申请日：2012-06-12

Applicant: Aydogan Ozcan ,  Michel J.F. Digonnet ,  Gordon S. Kino

Inventor： Aydogan Ozcan ,  Michel J.F. Digonnet ,  Gordon S. Kino

IPC: G01J3/45 ,  G06K9/36

CPC classification number: A61B5/0066 ,  A61B5/0073 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02083 ,  G01B9/02091 ,  G01N21/4795

Abstract: An apparatus and method process optical coherence tomography (OCT) imaging data from a sample. The method includes using a magnitude spectrum and an estimated phase term of a complex spatial Fourier transform of a complex intermediate function to generate an estimated complex spatial Fourier transform. The method further includes calculating an inverse Fourier transform of the estimated complex spatial Fourier transform and calculating an estimated intermediate function by applying at least one constraint to the inverse Fourier transform. The apparatus includes a partially reflective element configured to reflect a first portion of light and to allow a second portion of light to propagate through the partially reflective element and to reflect from the sample. The apparatus further includes a detector that measures the OCT power spectrum in response to the first and second portions of light.

Abstract translation: 来自样品的装置和方法处理光学相干断层扫描（OCT）成像数据。 该方法包括使用复数中间函数的复数空间傅里叶变换的幅度谱和估计相位项来生成估计的复数空间傅里叶变换。 该方法还包括通过对傅立叶逆变换应用至少一个约束来计算所估计的复数空间傅里叶变换的逆傅立叶变换并计算估计的中间函数。 该装置包括部分反射元件，其被配置为反射第一部分光并且允许光的第二部分传播通过部分反射元件并从样品反射。 该装置还包括响应于第一和第二部分光量测量OCT功率谱的检测器。