公开(公告)号：US20160041101A1

公开(公告)日：2016-02-11

申请号：US14886227

申请日：2015-10-19

Applicant: Laser-Laboratorium Göttingen e.V. ,  AIRSENSE Analytics GmbH

Inventor： Hainer Wackerbarth ,  Lars Gundrum ,  Bert Ungethuem ,  Wolf Muenchmeyer ,  Andreas Walte

IPC: G01N21/65 ,  G01N21/3504 ,  G01N33/22

CPC classification number: G01N21/658 ,  G01N21/3504 ,  G01N33/227 ,  G01N2021/1734 ,  G01N2021/258 ,  G01N2201/024 ,  G01N2201/06113

Abstract: The invention relates to identifying not easily volatilized substances, in particular hazardous material, in a gas phase. A measurement cell and gas supply installations connected to the measurement cell are heated, and a plasmonic surface arranged in the measurement cell is temperature-controlled such that the plasmonic surface has a lower temperature than the measurement cell and the gas supply installations. The gas phase is guided through the gas supply installations into the measurement cell such that the gas phase reaches the plasmonic surface. Substances adsorbed out of the gas phase on the plasmonic surface are analyzed by an optical process. Surface-enhanced Raman spectroscopy or surface-enhanced infrared spectroscopy may be used. Selectivity can be increased by combining both methods. Selectivity can be additionally increased by using a gas detector, preferably an ion-mobility spectrometer. Thus the false alarm rate is reduced without a loss of time.

Abstract translation: 本发明涉及在气相中识别不容易挥发的物质，特别是危险物质。 连接到测量单元的测量单元和气体供应装置被加热，并且布置在测量单元中的等离子体表面被温度控制，使得等离子体表面具有比测量单元和气体供应装置更低的温度。 气相通过气体供应装置被引导到测量单元中，使得气相到达等离子体激元表面。 通过光学方法分析吸附在等离子体表面上的气相中的物质。 可以使用表面增强拉曼光谱或表面增强红外光谱。 可以通过组合两种方法来提高选择性。 通过使用气体检测器，优选离子迁移谱仪可以增加选择性。 因此，在不损失时间的情况下，减少误报率。

公开(公告)号：US20160033544A1

公开(公告)日：2016-02-04

申请号：US14859064

申请日：2015-09-18

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Paul Patel ,  Semartha Anekal

IPC: G01N35/10 ,  G01N21/25 ,  G01N35/00

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20160025760A1

公开(公告)日：2016-01-28

申请号：US14872919

申请日：2015-10-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes

IPC: G01N35/04 ,  G01N35/02

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US09116158B2

公开(公告)日：2015-08-25

申请号：US13792853

申请日：2013-03-11

Applicant: VUV Analytics, Inc.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh

IPC: G01N21/00 ,  G01N30/74 ,  G01N21/33 ,  G01J3/02 ,  G01N30/02 ,  G01N33/00 ,  G01N21/05

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

Abstract translation: 提供了一种有效的吸收光谱系统。 光谱系统可以被配置为测量固体，液体或气体样品。 可以使用真空紫外线波长。 一些所公开的技术可用于检测痕量浓度的气态物质的存在。 公开了一种优选的气体流通池。 所公开的技术中的一些可以与气相色谱系统一起使用，以便检测和鉴定从柱洗脱的物质。 所公开的技术中的一些可以与电喷雾界面和液相色谱系统结合使用，以便检测和鉴定由溶液产生的大分子的气相离子。 所公开的技术中的一些可以用于表征化学反应。 一些所公开的技术可以与超短路径长度的样品池结合使用以测量液体。

公开(公告)号：US09103786B2

公开(公告)日：2015-08-11

申请号：US13457199

申请日：2012-04-26

Applicant: George Maltezos ,  Jeremy Witzens ,  Axel Scherer

Inventor： George Maltezos ,  Jeremy Witzens ,  Axel Scherer

IPC: F03B11/00 ,  F15C1/00 ,  G01N21/64 ,  G01N21/03 ,  F04B43/02 ,  B01L3/00 ,  B81C1/00 ,  G01N21/05

CPC classification number: G01N21/6428 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0683 ,  B81C1/00119 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/6456 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/0364 ,  G01N2201/024 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/1714 ,  Y10T137/2202 ,  Y10T137/8811

Abstract: An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence of target molecules in the biological sample. The apparatus further contains a light source to emit light for illumination of the microfluidic chip and an optical filter to allow passage of the light from the dies once activated or deactivated by the presence of the target molecules. A method for pressurizing a microfluidic chip is also disclosed, where a chamber is provided, the chamber is connected with the microfluidic chip and pressure is applied to the chamber.

Abstract translation: 用于分析样品，特别是生物样品的装置。 该装置包含具有管芯的微流体芯片，适于通过生物样品中目标分子的存在而被选择性地活化或失活。 该装置还包含用于发射微流芯片照明的光源和滤光器，以允许通过靶分子的存在激活或去激活来自模具的光的通过。 还公开了一种用于对微流体芯片加压的方法，其中设置有腔室，腔室与微流体芯片连接，并且将压力施加到腔室。

公开(公告)号：US20150203922A1

公开(公告)日：2015-07-23

申请号：US13637303

申请日：2011-03-17

Applicant: Edward J. Cargill ,  Kevin L. Deppermann ,  Brad D. White ,  William A. Grote ,  Elias J. Yannakakis ,  Andrew M. Singleton ,  D. David Grothaus ,  Tiffany L. Stephans ,  Allen T. Christian ,  Donald W. Mittanck ,  Yelena A. Dudin ,  Ramesh Govinthasamy

Inventor： Edward J. Cargill ,  Kevin L. Deppermann ,  Brad D. White ,  William A. Grote ,  Elias J. Yannakakis ,  Andrew M. Singleton ,  D. David Grothaus ,  Tiffany L. Stephans ,  Allen T. Christian ,  Donald W. Mittanck ,  Yelena A. Dudin ,  Ramesh Govinthasamy

IPC: C12Q1/68 ,  G01N21/64

CPC classification number: C12Q1/6895 ,  C12Q1/6844 ,  C12Q2600/13 ,  G01N21/643 ,  G01N21/645 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2201/0221 ,  G01N2201/024 ,  G01N2201/062 ,  G01N2201/0627

Abstract: Portable systems and methods for amplifying nucleotides and for detecting nucleotide sequences in a sample are provided. The portable instruments and methods use RPA techniques for DNA amplification and detect sample fluorescence in response to amplification and/or to the presence of specific DNA sequences.

Abstract translation: 提供了用于扩增核苷酸和检测样品中核苷酸序列的便携式系统和方法。 便携式仪器和方法使用RPA技术进行DNA扩增，并响应于扩增和/或特定DNA序列的存在而检测样品荧光。

公开(公告)号：US09068926B2

公开(公告)日：2015-06-30

申请号：US13501779

申请日：2010-10-07

Applicant: Wolfgang Schade

Inventor： Wolfgang Schade

IPC: G01N21/17 ,  H05K13/00

CPC classification number: G01N21/1702 ,  G01N2021/1704 ,  G01N2201/024 ,  Y10T29/41

Abstract: A photo-acoustic gas sensor and methods for producing same, the gas sensor having a resonance body and a device for detecting a vibration of the resonance body, including a device for optically detecting the location of at least one partial surface of the resonance body, wherein the resonance body and the device for detecting a vibration are disposed on exactly one substrate, the resonance body is formed by at least one first recess of the substrate, and the substrate is a semiconductor material.

Abstract translation: 一种光声气体传感器及其制造方法，所述气体传感器具有共振体和用于检测所述共振体的振动的装置，所述装置包括用于光学地检测所述共振体的至少一个部分表面的位置的装置， 其中所述共振体和用于检测振动的装置设置在恰好一个基板上，所述谐振体由所述基板的至少一个第一凹部形成，并且所述基板是半导体材料。

公开(公告)号：US08968658B2

公开(公告)日：2015-03-03

申请号：US13311164

申请日：2011-12-05

Applicant: Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

Inventor： Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

IPC: G01N21/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/427 ,  G01J3/44 ,  G01N21/76 ,  G01N21/64 ,  G01N21/17

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support of the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges may be a luminescence cartridge that includes an integrated detector that is movable toward and away from a sample carrier of the apparatus, and thus toward and away from a sample located at the sample carrier.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 该系统具有用于多模仪器的不同应用的多个盒。 墨盒以“插入”格式与装置的墨盒支架可拆卸地接合，使得一个墨盒可以从设备中取出，另一墨盒可以容易地安装。 盒支架包括同时接收盒的多个盒位置。 其中一个盒可以是发光盒，其包括集成检测器，该检测器可朝向和远离装置的样品载体移动，并且因此朝向和离开位于样品载体处的样品。

公开(公告)号：US20140379610A1

公开(公告)日：2014-12-25

申请号：US14309741

申请日：2014-06-19

Applicant: Thomas K. Lindeman

Inventor： Thomas K. Lindeman

IPC: G06Q30/02 ,  A61K36/185

CPC classification number: G06Q30/0282 ,  A61K36/185 ,  G01N21/03 ,  G01N21/643 ,  G01N21/77 ,  G01N21/78 ,  G01N2021/7786 ,  G01N2021/7796 ,  G01N2201/024

Abstract: A cannabis product updated user feedback system and method that informs users of the anticipated psychological and physiological effects of a cannabis product. The system includes the creation of an effects graph associated with the cannabis product that may be distributed with the cannabis product or presented on a website. The effects graph includes one or more line graphs depicting the effects and interactions experienced by all reporting users of the product. The system includes a website in which the feedback information regarding a particular cannabis product is collected. The administrator of the website then reviews the feedback information and provides updated line graph data. Each line graph shows the intensity of user-reported effects graded from 0 to an upper limit on the y axis over a time presented on the x axis. The effects graph may include icons that visually portray what a user consumed and how they felt. By viewing the line graph, a user can anticipated the effects, the intensity, when they occur and the duration.

Abstract translation: 大麻产品更新用户反馈系统和方法，向用户通报大麻产品的预期心理和生理影响。 该系统包括创建与大麻产品相关的效果图，可以与大麻产品一起分发或呈现在网站上。 效果图包括一条或多条描绘产品所有报告用户所经历的影响和相互作用的线形图。 该系统包括一个网站，其中收集有关特定大麻产品的反馈信息。 网站的管理员然后审查反馈信息并提供更新的线图数据。 每个线图显示在x轴上显示的时间内，用户报告的效果从0到Y轴上限的强度。 效果图可以包括在视觉上描绘用户消费以及感觉如何的图标。 通过查看线图，用户可以预期效果，强度，发生时间和持续时间。

公开(公告)号：US20140192343A1

公开(公告)日：2014-07-10

申请号：US13792853

申请日：2013-03-11

Applicant: VUV ANALYTICS, INC.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh

IPC: G01J3/02 ,  G01N30/02

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

Abstract translation: 提供了一种有效的吸收光谱系统。 光谱系统可以被配置为测量固体，液体或气体样品。 可以使用真空紫外线波长。 一些所公开的技术可用于检测痕量浓度的气态物质的存在。 公开了一种优选的气体流通池。 所公开的技术中的一些可以与气相色谱系统一起使用，以便检测和鉴定从柱洗脱的物质。 所公开的技术中的一些可以与电喷雾界面和液相色谱系统结合使用，以便检测和鉴定由溶液产生的大分子的气相离子。 所公开的技术中的一些可以用于表征化学反应。 一些所公开的技术可以与超短路径长度的样品池结合使用以测量液体。