公开(公告)号：US09217170B2

公开(公告)日：2015-12-22

申请号：US13948892

申请日：2013-07-23

Applicant: Blood Cell Storage, Inc.

Inventor： Michael W. Reed ,  Steven J. Geelhood ,  Paul C. Harris ,  Lynn M. Barker ,  Perry Hargrave ,  Oliver Z. Nanassy

IPC: G01N31/16 ,  G01N31/22 ,  C12Q1/22 ,  G01N21/64 ,  G01N21/77 ,  G01N33/49 ,  G01N33/542 ,  G01N33/58 ,  G01N33/84 ,  C12Q1/04 ,  C12Q1/54 ,  G01N21/80

CPC classification number: G01N33/84 ,  C12Q1/04 ,  C12Q1/22 ,  C12Q1/54 ,  G01N21/6428 ,  G01N21/77 ,  G01N21/80 ,  G01N33/492 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  G01N2021/6421 ,  G01N2021/6434 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/0826 ,  G01N2201/084 ,  G01N2400/00

Abstract: System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.

Abstract translation: 用于检测和测量样品中化学扰动的系统和方法。 该系统和方法可用于密封在储存袋中的血液或血液制品的非侵入性pH监测。

公开(公告)号：US09089828B2

公开(公告)日：2015-07-28

申请号：US14019687

申请日：2013-09-06

Applicant: IT-IS International Limited

Inventor： James Richard Howell ,  Benjamin Masterman Webster ,  Mark Quentin Clark ,  Richard Alfred Howell

IPC: B01J19/00 ,  G01N21/25 ,  G01N21/64

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting light emanating from chemical or biochemical reactions occurring in at least one reaction vessel of a plurality of reaction vessels is disclosed. Each reaction vessel has a receptacle portion having an emitting area from which light can emanate. A plurality of light waveguides are arranged to guide light from apertures in a masking element to a light dispersing device for dispersing the light from each waveguide into a dispersed spectrum. A light detecting device detects specific spectra in the dispersed spectra of light substantially simultaneously In one embodiment, the light waveguides have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter.

Abstract translation: 公开了一种用于检测在多个反应容器的至少一个反应容器中发生的化学或生物化学反应产生的光的装置。 每个反应容器具有容纳部分，该容器部分具有能够发出光的发射区域。 多个光波导被布置成将来自掩模元件中的孔的光引导到用于将来自每个波导的光分散到分散光谱中的光分散装置。 光检测装置基本上同时检测光的分散光谱中的特定光谱。在一个实施例中，光波导具有从直径基本上类似于第一端的直径与反应容器顶部的面积逐渐变细的直径， 其直径显着更小。

公开(公告)号：US20150018646A1

公开(公告)日：2015-01-15

申请号：US13941411

申请日：2013-07-12

Applicant: Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

Inventor： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/107

CPC classification number: G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

Abstract: A noninvasive analyzer apparatus and method of use thereof is described using a sample mapping phase to establish one or more analyzer/software parameters used in a subsequent individual and/or group specific data collection phase. For example, in the sample mapping phase distance between incident and collected light is varied as a function of time for collected noninvasive spectra. Spectra collected in the sample mapping phase are analyzed to determine a physiological property of the subject, such as dermal thickness, hydration, collagen density, epidermal thickness, and/or subcutaneous fat depth. Using the physiological property or measure thereof, the analyzer is optically reconfigured for the individual to yield subsequent spectra having enhanced features for noninvasive analyte property determination. Similarly, in the mapping and/or collection phase, the incident light is varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, and/or intensity.

Abstract translation: 使用样本映射阶段来描述非侵入性分析仪装置及其使用方法，以建立在随后的个体和/或组特定数据收集阶段中使用的一个或多个分析器/软件参数。 例如，在样本映射中，入射光和收集光之间的距离随收集的无创光谱的时间而变化。 分析在样品测绘阶段收集的光谱，以确定受试者的生理性质，例如真皮厚度，水合，胶原密度，表皮厚度和/或皮下脂肪深度。 使用生理特性或其测量方式，分析仪对于个体进行光学重新配置，以产生具有用于非侵入性分析物质确定的增强特征的后续光谱。 类似地，在映射和/或收集阶段，入射光在时间上根据以下任一种而变化：样本探针位置，入射光立体角，入射光角，焦深，能量和/或强度。

公开(公告)号：US08638440B1

公开(公告)日：2014-01-28

申请号：US13927223

申请日：2013-06-26

Applicant: Paul R. Ohodnicki, Jr. ,  Congjun Wang ,  Mark A. Andio

Inventor： Paul R. Ohodnicki, Jr. ,  Congjun Wang ,  Mark A. Andio

IPC: G01N21/00 ,  G01N21/55

CPC classification number: G01N21/783 ,  G01N2201/0826

Abstract: The disclosure relates to a method of detecting a change in a chemical composition by contacting a doped oxide material with a monitored stream, illuminating the doped oxide material with incident light, collecting exiting light, monitoring an optical signal based on a comparison of the incident light and the exiting light, and detecting a shift in the optical signal. The doped metal oxide has a carrier concentration of at least 1018/cm3, a bandgap of at least 2 eV, and an electronic conductivity of at least 101 S/cm, where parameters are specified at a temperature of 25° C. The optical response of the doped oxide materials results from the high carrier concentration of the doped metal oxide, and the resulting impact of changing gas atmospheres on that relatively high carrier concentration. These changes in effective carrier densities of conducting metal oxide nanoparticles are postulated to be responsible for the change in measured optical absorption associated with free carriers. Exemplary doped metal oxides include but are not limited to Al-doped ZnO, Sn-doped In2O3, Nb-doped TiO2, and F-doped SnO2.

Abstract translation: 本公开涉及通过使掺杂的氧化物材料与监测的流接触来检测化学组成的变化的方法，用入射光照射掺杂的氧化物材料，收集离开的光，基于入射光的比较监测光学信号 和出射光，并检测光信号的偏移。 掺杂的金属氧化物具有至少1018 / cm3的载流子浓度，至少2eV的带隙和至少101S / cm的电子导电率，其中在25℃的温度下规定了参数。光学响应 掺杂的氧化物材料由掺杂的金属氧化物的高载流子浓度导致，并且由此改变气体气氛对所述相对高的载流子浓度的影响。 假设导电金属氧化物纳米颗粒的有效载流子密度的这些变化是造成与自由载体相关的测量的光吸收的变化的原因。 示例性的掺杂金属氧化物包括但不限于掺杂Al的ZnO，掺杂Sn的In 2 O 3，掺杂Nb的TiO 2和F掺杂的SnO 2。

公开(公告)号：US20140005078A1

公开(公告)日：2014-01-02

申请号：US14019687

申请日：2013-09-06

Applicant: IT-IS International Limited

Inventor： James Richard Howell ,  Benjamin Masterman Webster ,  Mark Quentin Clark ,  Richard Alfred Howell

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting light emanating from chemical or biochemical reactions occurring in at least one reaction vessel of a plurality of reaction vessels is disclosed. Each reaction vessel has a receptacle portion having an emitting area from which light can emanate. A plurality of light waveguides are arranged to guide light from apertures in a masking element to a light dispersing device for dispersing the light from each waveguide into a dispersed spectrum. A light detecting device detects specific spectra in the dispersed spectra of light substantially simultaneously In one embodiment, the light waveguides have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter.

Abstract translation: 公开了一种用于检测在多个反应容器的至少一个反应容器中发生的化学或生物化学反应产生的光的装置。 每个反应容器具有容纳部分，该容器部分具有能够发出光的发射区域。 多个光波导被布置成将来自掩模元件中的孔的光引导到用于将来自每个波导的光分散到分散光谱中的光分散装置。 光检测装置基本上同时检测光的分散光谱中的特定光谱。在一个实施例中，光波导具有从直径基本上类似于第一端的直径与反应容器顶部的面积逐渐变细的直径， 其直径显着更小。

公开(公告)号：US08543180B2

公开(公告)日：2013-09-24

申请号：US12875983

申请日：2010-09-03

Applicant: Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

Inventor： Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0091 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4312 ,  A61B5/6814 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0233 ,  A61B2562/046 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The present invention pertains to a method and apparatus for total hemoglobin measurement. A modulated optical signal based on a digital code sequence is transmitted to human tissue. A temporal transfer characteristic is derived from the modulated optical signal. Total hemoglobin is determined based on the temporal transfer characteristic.

Abstract translation: 本发明涉及总血红蛋白测量的方法和装置。 基于数字码序列的调制光信号被传送到人体组织。 从调制光信号导出时间传递特性。 基于时间转移特性确定总血红蛋白。

公开(公告)号：US08536516B2

公开(公告)日：2013-09-17

申请号：US13452128

申请日：2012-04-20

Applicant: Jess V. Ford ,  Thomas Blankinship ,  Bryan W. Kasperski ,  Margaret C. Waid ,  Sean M. Christian

Inventor： Jess V. Ford ,  Thomas Blankinship ,  Bryan W. Kasperski ,  Margaret C. Waid ,  Sean M. Christian

IPC: G01V5/04

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/12 ,  G01J3/4338 ,  G01J2003/1226 ,  G01N2201/0612 ,  G01N2201/0625 ,  G01N2201/0627 ,  G01N2201/0691 ,  G01N2201/0826 ,  G02B6/4215 ,  G02B6/4249

Abstract: A multi-channel source assembly for downhole spectroscopy has individual sources that generate optical signals across a spectral range of wavelengths. A combining assembly optically combines the generated signals into a combined signal and a routing assembly that splits the combined signal into a reference channel and a measurement channel. Control circuitry electrically coupled to the sources modulates each of the sources at unique or independent frequencies during operation.

Abstract translation: 用于井下光谱的多通道源组件具有在波长的光谱范围上产生光信号的各个源。 组合组合将所生成的信号光学地组合成组合信号和将组合信号分离成参考通道和测量通道的路由组件。 电耦合到源的控制电路在操作期间以独特或独立的频率调制每个源。

公开(公告)号：US20130228675A1

公开(公告)日：2013-09-05

申请号：US13782950

申请日：2013-03-01

Applicant: LAXCO, INC.

Inventor： Cong Liang Chen ,  Kevin Cassady

IPC: G01N21/01 ,  G02B6/04 ,  G01N21/17

CPC classification number: G01N21/0303 ,  G01N21/01 ,  G01N21/17 ,  G01N21/253 ,  G01N21/27 ,  G01N21/6452 ,  G01N2201/0639 ,  G01N2201/08 ,  G01N2201/0826 ,  G02B6/006 ,  G02B6/04 ,  G02B6/29388 ,  G02B6/32

Abstract: An analytical instrument may have multiple distinct channels. Such may include one or more illumination sources and sensors. Illumination may be delivered to specific locations of a specimen holder, and returned illumination may be delivered to specific locations of a sensor array. Illumination may first pass a specimen, and a mirror or reflector may then return the illumination past the specimen. Optical splitters may be employed to couple pairs of fiber optics proximate a specimen holder. Such channels may further include a plurality of illumination sources positioned on one side of a specimen holder and a plurality of sensors on the other side. The plurality of sensor may capture image of a specimen and a spectrophotometer may concurrently scan the specimen. A plurality of specimens may be imaged and scanned in a single pass of a plurality of passes. Spherical or ball lenses may be placed in an optical path of the illumination to achieve a desired illumination pattern.

Abstract translation: 分析仪器可能具有多个不同的通道。 这样可以包括一个或多个照明源和传感器。 照明可以被传送到样本保持器的特定位置，并且返回的照明可以被传送到传感器阵列的特定位置。 照明可以首先通过样本，然后镜子或反射器可以使照射通过样本。 可以使用光分路器将靠近样本保持器的成对的光纤耦合。 这样的通道还可以包括位于样品架一侧的多个照明源和另一侧的多个传感器。 多个传感器可以捕获样本的图像，并且分光光度计可以同时扫描样本。 可以在多次通过的单次通过中对多个样本进行成像和扫描。 球形或球形透镜可以放置在照明的光路中以实现期望的照明图案。

公开(公告)号：US08497134B2

公开(公告)日：2013-07-30

申请号：US11789431

申请日：2007-04-23

Applicant: Michael W. Reed ,  Steven J. Geelhood ,  Paul C. Harris ,  Lynn M. Barker ,  Perry Hargrave ,  Oliver Nanassy

Inventor： Michael W. Reed ,  Steven J. Geelhood ,  Paul C. Harris ,  Lynn M. Barker ,  Perry Hargrave ,  Oliver Nanassy

IPC: G01N31/16 ,  G01N31/22

CPC classification number: G01N33/84 ,  C12Q1/04 ,  C12Q1/22 ,  C12Q1/54 ,  G01N21/6428 ,  G01N21/77 ,  G01N21/80 ,  G01N33/492 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  G01N2021/6421 ,  G01N2021/6434 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/0826 ,  G01N2201/084 ,  G01N2400/00

Abstract: System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.

公开(公告)号：US08455844B2

公开(公告)日：2013-06-04

申请号：US12722446

申请日：2010-03-11

Applicant: Kevin L. Lear ,  Sean B. Pieper

Inventor： Kevin L. Lear ,  Sean B. Pieper

IPC: G01N21/64

CPC classification number: G01N21/7703 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/80 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A measurement system for use with fluorescent chemosensors has multiple stimulus light sources each coupled to at least one sensor. Multiple sensors each receiving light from a different light source connect to each of one or more photodetectors. A processing device drives the light sources in a time-division multiplexed manner, and reads the photodetector at an appropriate time for each sensor. The processing device calibrates the sensor readings and provides them in a way that is identified to the associated sensor.

Abstract translation: 用于荧光化学传感器的测量系统具有多个激励光源，每个激光光源耦合到至少一个传感器。 各自接收来自不同光源的光的多个传感器连接到一个或多个光电检测器中的每一个。 处理装置以时分复用的方式驱动光源，并且在每个传感器的适当时间读取光电检测器。 处理装置校准传感器读数并以对相关传感器识别的方式提供它们。