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    Spectroscopic systems and methods for classifying and pharmaceutically treating cells
    173.
    发明申请
    Spectroscopic systems and methods for classifying and pharmaceutically treating cells 有权
    用于分类和药物治疗细胞的光谱系统和方法

    公开(公告)号：US20100093015A1

    公开(公告)日：2010-04-15

    申请号：US12462350

    申请日：2009-08-03

    Applicant: Janice L. Panza ,  John Maier ,  Jason Neiss

    Inventor： Janice L. Panza ,  John Maier ,  Jason Neiss

    IPC: C12Q1/02 ,  C12M1/34

    CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J3/36 ,  G01N15/1475 ,  G01N21/6458 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1488 ,  G02B21/0096

    Abstract: A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent.

    Abstract translation: 将正常细胞与经历生物化学变化的细胞区分开的系统和方法。 选择预定向量空间，其中矢量空间数学地描述正常小区的第一多个参考频谱数据集，以及已经历生化变化的小区的第二多个参考频谱数据集。 照射样品以基于样品吸收，反射，发射或散射的光子产生目标光谱数据集。 将目标光谱数据集转换为预定向量空间。 在预定向量空间中分析变换数据的分布。 基于该分析，将样品分类为含有正常细胞，经历生物化学变化的细胞及其组合。 该方法包括在照射样品之前用药剂处理样品并使用分类来评估药剂的效率。

    Multispectral Filter For An Image Detection Device, Improved Image Detection Device For A Multispectral Imager and Multispectral Imager Comprising This Filter
    174.
    发明申请
    Multispectral Filter For An Image Detection Device, Improved Image Detection Device For A Multispectral Imager and Multispectral Imager Comprising This Filter 有权
    用于图像检测装置的多光谱滤波器，用于包含该滤波器的多光谱成像器和多光谱成像器的改进的图像检测装置

    公开(公告)号：US20100065725A1

    公开(公告)日：2010-03-18

    申请号：US12548047

    申请日：2009-08-26

    Applicant: Jean-François Blanc ,  Stéphane Garin

    Inventor： Jean-François Blanc ,  Stéphane Garin

    IPC: G01J3/50 ,  G02B5/04

    CPC classification number: G02B23/00 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0213 ,  G01J3/0262 ,  G01J3/2823 ,  G01J3/36 ,  G02B5/285 ,  H01L27/14621

    Abstract: The multispectral filter for an image detection device comprises a prismatic plate (85) comprising a first internal face (86) and a second external face (87), the first and the second faces (86, 87) being inclined with respect to one another by an angle β, and comprises at least two different spectral bands (91, 92, 93, 94) deposited either on the first or the second face (86, 87) of the prismatic plate (85), the various spectral bands (91, 92, 93, 94) being spaced a predetermined distance (D) apart.Application to multispectral imagers, in particular to Off Axis imagers.This filter allows the suppression of the ghost images (or spurious echoes) generated at the focal plane of a multispectral imager.

    Abstract translation: 用于图像检测装置的多光谱滤光器包括棱镜板（85），其包括第一内表面（86）和第二外表面（87），第一和第二面（86,87）相对于彼此倾斜 并且包括沉积在棱镜板（85）的第一面或第二面（86,87）上的至少两个不同光谱带（91,92,93,94），各种光谱带（ 91,92,93,94）间隔开预定距离（D）。 应用于多光谱成像仪，特别是Off Axis成像仪。 该滤光器允许抑制在多光谱成像器的焦平面处产生的重影图像（或杂散回波）。

    Optical imaging device for splitting an initial image into at least two images
    175.
    发明授权
    Optical imaging device for splitting an initial image into at least two images 有权
    用于将初始图像分割成至少两个图像的光学成像装置

    公开(公告)号：US07667761B2

    公开(公告)日：2010-02-23

    申请号：US11167442

    申请日：2005-06-27

    Applicant: Martin Thomas

    Inventor： Martin Thomas

    IPC: G02B13/16

    CPC classification number: G02B27/144 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0291 ,  G01J3/36 ,  G02B27/1006 ,  G02B27/14 ,  G02B27/141

    Abstract: There is provided an optical imaging device (18) for splitting an initial image into at least two images with different optical characteristics. The device comprises a dichroic mirror (32) to create first and second optical pathways respectively incident on first and second mirrors (41, 41′) carried on a centrally pivoted rotatable arm, characterised in that the first and second reflective means are moveable along the arm (42) whilst held in fixed relationship to each other, thereby to adjust separation of the first and second optical pathways. A third mirror (46) in fixed relationship to the beam splitter (32) is positioned adjacent where the first and second optical pathways intersect, or just before the intersection of the first and second optical pathways, or just after the point of intersection.

    Abstract translation: 提供了一种用于将初始图像分解成具有不同光学特性的至少两个图像的光学成像装置（18）。 该装置包括分色镜（32），以产生分别入射在承载在中心枢转的可旋转臂上的第一和第二反射镜（41,41'）上的第一和第二光学通路，其特征在于，第一和第二反射装置可沿着 臂（42），同时保持彼此固定的关系，从而调节第一和第二光学路径的分离。 与分束器（32）固定关系的第三反射镜（46）位于第一和第二光学路径相交处或邻近于第一和第二光学路径的相交处之前，或恰好在交点之后。

    Multiplexed raman detection with filter set
    176.
    发明授权
    Multiplexed raman detection with filter set 有权
    多路复用拉曼检测与滤波器组

    公开(公告)号：US07656523B2

    公开(公告)日：2010-02-02

    申请号：US11477379

    申请日：2006-06-30

    Applicant: Lei Sun ,  Tae-Woong Koo ,  Liming Wang

    Inventor： Lei Sun ,  Tae-Woong Koo ,  Liming Wang

    IPC: G01J3/44

    CPC classification number: G01N21/658 ,  G01J3/36 ,  G01J3/44

    Abstract: A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.

    Abstract translation: 利用多个光电倍增管（PMT）或与一组滤波器耦合的光电二极管以从样品收集拉曼信号的装置（以及使用和制造该装置的方法）。 检测拉曼信号的方法还包括利用多个光电倍增管（PMT）或光电二极管从样品接收拉曼信号，其中至少一个PMT或光电二极管提供与至少一个其它PMT或光电二极管不同的拉曼信号。

    OPTICAL SYSTEM, METHOD, AND COMPUTER READABLE MEDIUM
    179.
    发明申请
    OPTICAL SYSTEM, METHOD, AND COMPUTER READABLE MEDIUM 失效
    光学系统，方法和计算机可读介质

    公开(公告)号：US20090244537A1

    公开(公告)日：2009-10-01

    申请号：US12415284

    申请日：2009-03-31

    Applicant: Takashi Murooka ,  Hideyasu Ishibashi

    Inventor： Takashi Murooka ,  Hideyasu Ishibashi

    IPC: G01B11/06 ,  G01J4/00

    CPC classification number: G01B11/0625 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/018 ,  A61B1/042 ,  A61B5/0084 ,  A61B5/1076 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/36

    Abstract: An optical system includes a light sending section that sends light to an object having a scattering medium and a lower medium positioned below the scattering medium, where the scattering medium scatters light and the lower medium feeds back polarized light in response to light incident thereon, a light receiving section that receives (i) light that is sent from the light sending section and then scattered by the scattering medium and (ii) light from the lower medium, and a thickness calculating section that calculates a thickness of the scattering medium, by referring to at least one of a non-polarization component and a polarization component of the light received by the light receiving section.

    Abstract translation: 光学系统包括发光部分，其向具有散射介质的物体和位于散射介质下方的下介质发射光，其中散射介质散射光，并且下介质响应于入射到其上的光反馈偏振光， 光接收部，其接收（i）从所述发光部发送的光然后被所述散射介质散射的光和（ii）来自所述下介质的光;以及厚度计算部，其通过引用来计算所述散射介质的厚度 涉及由光接收部接收的光的非偏振分量和偏振分量中的至少一个。

    Multi-band focal plane array
    180.
    发明授权
    Multi-band focal plane array 有权
    多波段焦平面阵列

    公开(公告)号：US07592593B2

    公开(公告)日：2009-09-22

    申请号：US11493121

    申请日：2006-07-26

    Applicant: Christopher Lee Kauffman ,  Gerald Pray Griffith ,  Ronald B. Jones ,  Sung-Shik Yoo ,  Michael A. Davis

    Inventor： Christopher Lee Kauffman ,  Gerald Pray Griffith ,  Ronald B. Jones ,  Sung-Shik Yoo ,  Michael A. Davis

    IPC: H01L25/00

    CPC classification number: H01L27/14649 ,  G01J3/36

    Abstract: A multi-band focal plane array architecture operative to detect multiple spectral image. The multi-band focal plane array architecture has an integrated readout circuit, a plurality of first detectors integrated in the readout circuit and a plurality of second detectors deposited on the readout circuit. Preferably, the first detectors are operative to detect visible signals and the second detectors are operative to detect infrared signals. The first and second detectors are arranged in a checkerboard pattern, in alternate rows or columns, or at least partially overlapped with each other to realize simultaneous detection in two different wavelength bands. The architecture may also have an additional integrated readout circuit flip-chip bonded to the integrated readout circuit. By forming a plurality of third detectors on the additional integrated readout circuit, a tri-band focal plane array may be realized. In one embodiment, a dual-band focal plane array architecture by forming two arrays of detectors on two individual integrated readout circuit and flip-chip bonding these two readout circuits.

    Abstract translation: 一种可以检测多个光谱图像的多波段焦平面阵列结构。 多频带焦平面阵列结构具有集成读出电路，集成在读出电路中的多个第一检测器和沉积在读出电路上的多个第二检测器。 优选地，第一检测器可操作以检测可见信号，并且第二检测器可操作以检测红外信号。 第一和第二检测器被布置成棋盘图案，以交替行或列排列，或至少部分地彼此重叠，以实现两个不同波长带中的同时检测。 该架构还可以具有结合到集成读出电路的额外的集成读出电路倒装芯片。 通过在附加集成读出电路上形成多个第三检测器，可以实现三波段焦平面阵列。 在一个实施例中，双波段焦平面阵列架构通过在两个单独的集成读出电路上形成两个检测器阵列并将这两个读出电路进行倒装芯片接合。

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