公开(公告)号：US20070281322A1

公开(公告)日：2007-12-06

申请号：US11805185

申请日：2007-05-21

Applicant: Claudia Jaffe ,  Steven Jaffe ,  Michieal Jones

Inventor： Claudia Jaffe ,  Steven Jaffe ,  Michieal Jones

IPC: G01N33/53 ,  G01J3/427

CPC classification number: G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

Abstract translation: 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。

公开(公告)号：US20070065935A1

公开(公告)日：2007-03-22

申请号：US10556961

申请日：2004-05-18

Applicant: Tomas Lindstrom ,  Ove Ohman

Inventor： Tomas Lindstrom ,  Ove Ohman

IPC: C12M3/00 ,  G01J3/42 ,  G01J3/427

CPC classification number: G01N21/6452 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01L3/508 ,  B01L3/5088 ,  B01L2300/0636 ,  B01L2300/0654 ,  G01N21/648 ,  G01N33/54373

Abstract: The invention comprises a polymeric microarray support (1) for an optical assay arrangement (2) comprising optical means (3, 4, 6) for detection of light emitted from the support. The microarray support is provided with microfeatures comprising a surface enlarging pattern (5), i.e. grooves having a selected depth (8). The depth is selected such that the sum of the depth and of the variations in the thickness (7) of the support substantially corresponds to the depth of focus of the optical means.

Abstract translation: 本发明包括用于光学测定装置（2）的聚合物微阵列支架（1），其包括用于检测从支撑体发出的光的光学装置（3,4,6）。 微阵列支撑件具有包括表面放大图案（5）的微特征，即具有选定深度（8）的凹槽。 深度被选择为使得支撑件的厚度（7）的深度和变化的总和基本上对应于光学装置的焦深。

公开(公告)号：US20050014248A1

公开(公告)日：2005-01-20

申请号：US10485505

申请日：2002-08-02

Applicant: Michel Canton

Inventor： Michel Canton

IPC: G01N15/14 ,  C12M1/34 ,  G01J3/42 ,  G01J3/427

CPC classification number: G01N15/1436 ,  G01N15/1484

Abstract: The invention concerns a device for analysing a sample comprising a sample receptacle (8) and a mirror (38), the mirror (38) comprising a break (40) such that a light beam (42) can pass through the mirror to reach the receptacle (8). The invention also concerns an assembly for analysing a sample comprising a device (2) and an equipment having a removable housing for receiving the device and a light source, the source being adapted to emit a light beam (42) passing through the mirror (38) to reach the receptacle (8) when the device is in the housing.

Abstract translation: 本发明涉及一种用于分析包括样品容器（8）和反射镜（38）的样品的装置，所述反射镜（38）包括破裂（40），使得光束（42）可以穿过反射镜以达到 容器（8）。 本发明还涉及一种用于分析样品的组件，该样品包括装置（2）和具有用于接收该装置的可移除壳体和光源的设备，该源适于发射穿过反射镜（38）的光束（42） ）当设备在壳体中时到达容器（8）。

公开(公告)号：US6124937A

公开(公告)日：2000-09-26

申请号：US308262

申请日：1999-05-14

Applicant: Klaus-Henrik Mittenzwey ,  Gert Sinn

Inventor： Klaus-Henrik Mittenzwey ,  Gert Sinn

IPC: G01N21/03 ,  G01N21/41 ,  G01N21/47 ,  G01N21/59 ,  G01N21/64 ,  G01N21/00 ,  G01J3/42 ,  G01J3/427

CPC classification number: G01N21/645 ,  G01N21/031 ,  G01N21/41 ,  G01N21/47 ,  G01N21/5907 ,  G01N2021/6484 ,  G01N2021/6491 ,  G01N2201/024

Abstract: The invention relates to the synchronous determination of the absorption, fluorescence, dispersion and refraction of liquids, gases and solids (measurement volumes) with high sensitivity. Radiation of defined wavelength is coupled into a multiple reflection device. The transmitted coupling radiation is measured with a receiver that is located immediately behind a semireflecting mirror. The diffuse reflecting that is directed against the direction of incidence and the radiation which is specularly reflected at the boundary surface with the measurement volume are measured with a receiver that is directed at the measurement volume and located on the coupling mirror. The absorbing power is determined from the reciprocal value of the transmitted coupling radiation. The scattering power and fluorescence power are determined indirectly from the combination of diffuse reflection and transmitted radiation. The refraction is determined from the combination of specularly reflected radiation and transmitted radiation. The invention describes a method and a simple and robust device designed in modular system. Ranges of application are analysis, quality control and inspection in industry, environment and medicine.

Abstract translation: PCT No.PCT / DE97 / 02718 Sec。 371日期1999年5月12日 102（e）日期1999年5月12日PCT 1997年11月14日PCT公布。 第WO98 / 22802号公报 日期1998年5月28日本发明涉及具有高灵敏度的液体，气体和固体（测量体积）的吸收，荧光，分散和折射的同步测定。 限定波长的辐射被耦合到多重反射装置中。 传输的耦合辐射用位于半反射镜后面的接收器测量。 用与测量体积在边界表面镜面反射的入射方向和辐射的漫反射用针对测量体积并位于耦合镜上的接收器测量。 吸收功率由透射的耦合辐射的倒数确定。 从漫反射和透射辐射的组合间接地确定散射光和荧光强度。 折射由镜面反射辐射和透射辐射的组合确定。 本发明描述了一种在模块化系统中设计的方法和简单而鲁棒的设备。 应用范围是行业，环境和医学领域的分析，质量控制和检验。

公开(公告)号：US5600443A

公开(公告)日：1997-02-04

申请号：US504892

申请日：1995-07-20

Applicant: Thomas H. Frey ,  Isaiah Lieberman

Inventor： Thomas H. Frey ,  Isaiah Lieberman

IPC: C09D11/16 ,  G01N21/27 ,  G01N21/31 ,  G01N21/78 ,  G01N21/80 ,  G01J3/427 ,  G01J3/50

CPC classification number: C09D11/16 ,  G01N21/272 ,  G01N21/31 ,  G01N21/80 ,  G01N21/78

Abstract: A method and ink composition are disclosed that utilize two mechanisms for the purpose of indicating the approximate age of an ink that has been deposited on a writing surface. The first mechanism relates to detecting color shifts of pH sensitive compounds in the ink as the result of the evaporation of certain acidic or basic chemicals thereof. The second mechanism relates to the oxidation of compounds in the ink. Spectroscopically generated curves are plotted as the ratio of reactants to products, versus time. The spectral characteristics of the ink are determined in units of percent reflectance of the active compounds in the ink so that the age of the ink can be computed by reference to known reaction rates. A plurality of dyes having differing reaction rates may be added to the ink to enable precise measurements to be made over different time intervals.

Abstract translation: 公开了一种方法和油墨组合物，其利用两种机制来指示已经沉积在书写表面上的油墨的大致年龄。 第一种机制涉及由于其某些酸性或碱性化学品的蒸发而检测墨水中pH敏感化合物的色偏。 第二种机理涉及油墨中化合物的氧化。 将光谱生成的曲线绘制为反应物与产物的比例，相对于时间。 油墨的光谱特性以墨水中活性化合物的反射率百分比为单位来确定，以便可以参照已知的反应速率来计算墨水的寿命。 可以将多种具有不同反应速率的染料加入到油墨中，以便能够在不同的时间间隔内进行精确的测量。

公开(公告)号：US5278402A

公开(公告)日：1994-01-11

申请号：US73953

申请日：1993-06-09

Applicant: Steven J. Wein

Inventor： Steven J. Wein

IPC: G01J3/28 ,  G01J3/427 ,  G01N21/41 ,  G01J1/20 ,  G01J3/50

CPC classification number: G02B27/0031 ,  G01N21/41 ,  G02B26/0883 ,  G01J3/2803 ,  G01J3/427 ,  G01N2021/4106 ,  G01N2021/4113 ,  G02B5/04

Abstract: An optical dispersion sensor for sensing optical dispersion introduced by the atmosphere in near real-time and an optical system using the dispersion sensor to compensate for atmospheric dispersion are described. The input signal to the dispersion sensor is the image of the scene being viewed by a scanning optical system. The image of the scene is passed through an aperture near the image plane of the optical system and then onto at least two individual light detecting systems. One of the detecting systems is adapted to detect light of a first wavelength band. The other detecting system detects light of a second wavelength band. The sensor computes the relative time delay between the signals derived from the two detecting systems. The time delay indicates the spectral dispersion introduced by the atmosphere. In an optical system, a control circuit adjusts a variable dispersive element contained within the optical system to compensate for the atmospheric dispersion by driving the relative time delay between signals towards zero.

Abstract translation: 描述了用于感测近乎实时的大气引入的光学色散的光学色散传感器和使用该色散传感器补偿大气分散的光学系统。 到色散传感器的输入信号是由扫描光学系统观看的场景的图像。 场景的图像通过光学系统的图像平面附近的孔，然后通过至少两个单独的光检测系统。 检测系统之一适于检测第一波长带的光。 另一检测系统检测第二波长带的光。 传感器计算从两个检测系统得到的信号之间的相对时间延迟。 时间延迟表示由大气引入的光谱色散。 在光学系统中，控制电路调节光学系统中包含的可变色散元件，以通过将信号之间的相对时间延迟驱动到零来补偿大气分散。

公开(公告)号：US5263776A

公开(公告)日：1993-11-23

申请号：US951280

申请日：1992-09-25

Applicant: David W. Abraham ,  William M. Holber ,  Joseph S. Logan ,  Hemantha K. Wickramasinghe

Inventor： David W. Abraham ,  William M. Holber ,  Joseph S. Logan ,  Hemantha K. Wickramasinghe

IPC: G01K11/00 ,  G01J3/427 ,  G01J3/45

CPC classification number: G01K11/00

Abstract: Multi-wavelength optical thermometry provides for non-contact measurement of the temperature of a sample where the front surface and the back surface of the sample are used in a interferometer to measure changes in optical path length. Laser beams at two different wavelengths are used and the beam phase of the two resultant interference signals is used to unambiguously measure the path length change over a broad temperature range.

Abstract translation: 多波长光学温度测量提供样品的温度的非接触式测量，其中样品的前表面和背面用于干涉仪中以测量光程长度的变化。 使用两个不同波长的激光束，并且使用两个合成的干涉信号的光束相位来明确地测量在宽的温度范围内的路径长度变化。

公开(公告)号：US5094958A

公开(公告)日：1992-03-10

申请号：US575165

申请日：1990-08-30

Applicant: Stanley M. Klainer ,  Kisholoy Goswami

Inventor： Stanley M. Klainer ,  Kisholoy Goswami

IPC: G01N21/27 ,  G01J3/427 ,  G01N21/64 ,  G01N21/77

CPC classification number: G01N21/7703 ,  G01N21/648 ,  G01J3/427 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6434 ,  G01N2021/6441 ,  G01N2021/7786

Abstract: A chemical sensor, such as a fiber optic chemical sensor, is self-calibrated by measuring two output values which behave differently in response to an analyte, and forming a ratio between the two measured output values to cancel out effects of variations in external factors such as temperature variations, differences between coatings, light (illuminator) variations, fouling, bleaching, leaching or the like. An indicator material may be used which produces both fluorescence and phosphorescence, both monomer and aggregate emission or absorption bands, emission or absorption bands with or without an isosbestic point, emission peaks at one wavelength at two different excitation bands, or emission peaks at two wavelengths for excitation at two wavelengths.

Abstract translation: 化学传感器，如光纤化学传感器，通过测量响应于分析物的不同行为的两个输出值进行自校准，并形成两个测量输出值之间的比值，以消除外部因素变化的影响，如 作为温度变化，涂层之间的差异，光（照射器）变化，结垢，漂白，浸出等。 可以使用指示剂材料，其产生荧光和磷光，单体和聚集体发射或吸收带，具有或不具有等腰点的发射或吸收带，两个不同激发带处的一个波长的发射峰或两个波长处的发射峰 用于在两个波长的激发。

公开(公告)号：US4972331A

公开(公告)日：1990-11-20

申请号：US307066

申请日：1989-02-06

Applicant: Britton Chance

Inventor： Britton Chance

IPC: G01J3/42 ,  A61B5/00 ,  G01J3/427 ,  G01J9/04 ,  G01N21/27 ,  G01N21/49

CPC classification number: G01N21/49 ,  A61B5/1455 ,  A61B5/14553 ,  G01J9/04 ,  G01N2021/1791 ,  G01N2201/06113

Abstract: The present invention to provides methods and apparatus for studying photon migration using signal modulation techniques such as time, frequency and phase modulation. The photon migration data may then be converted, using the principles of time-resolved spectroscopy, to determine the concentration of an absorptive constituent in a scattering medium, such as the concentration of hemoglobin in a brain of other tissue. The methods and apparatus of the present invention provide as a specific embodiment, a dual wavelength phase modulation system which allows the clinical application of time resolved spectroscopy in a commerically feasible embodiment.

Abstract translation: 本发明提供了使用诸如时间，频率和相位调制之类的信号调制技术研究光子迁移的方法和装置。 然后可以使用时间分辨光谱学的原理转换光子迁移数据，以确定散射介质中的吸收成分的浓度，例如其他组织脑中血红蛋白的浓度。 本发明的方法和装置提供了一种双波长相位调制系统作为具体实施例，其允许在商业上可行的实施例中临时应用时间分辨光谱。

公开(公告)号：US4795256A

公开(公告)日：1989-01-03

申请号：US23567

申请日：1987-03-09

Applicant: Andrew W. Krause ,  Charles G. Marianik ,  Ronald J. Kovach

Inventor： Andrew W. Krause ,  Charles G. Marianik ,  Ronald J. Kovach

IPC: G01J3/427 ,  G01J3/44 ,  G01J3/08 ,  G01N21/64

CPC classification number: G01J3/427 ,  G01J3/4406

Abstract: A dual wavelength spectrophotometer produces a relatively small, high power, high duty cycle light spot from a single relatively low power multi-chromatic light source. A Xenon arc lamp light source is focused by an ellipsoidal mirror onto a rotating partially reflective optical chopper. The chopper comprises a wheel having mirrored segments alternately separated by transparent segments. Light reflected by the mirrored segments passes through a first monochromator which produces a first monochromatic light beam. Light transmitted through the transparent segments passes through a second monochromator and emerges as a second monochromatic light beam having a wavelength different from the wavelength of said first monochromatic light beam. The first and second monochromatic light beams are recombined into a single dual wavelength light beam that is reflected through a sample to be analyzed. Reflective front surfaces are employed throughout the system in order to minimize power loss.

Abstract translation: 双波长分光光度计从单个相对低功率的多色光源产生相对较小的高功率，高占空比的光斑。 氙弧灯光源通过椭圆面镜聚焦到旋转的部分反射的光斩波器上。 斩波器包括具有由透明段交替分开的镜像段的车轮。 由镜像段反射的光穿过产生第一单色光束的第一单色仪。 透过透明区段的光通过第二单色仪，并作为具有不同于所述第一单色光束的波长的波长的第二单色光束而出射。 第一和第二单色光束被复合成单个双波长光束，其被反射通过要分析的样品。 在整个系统中采用反射前表面，以最大限度地减少功率损耗。