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    Polymeric Nanopillars and Nanotubes, Their Manufacture and Uses
    181.
    发明申请
    Polymeric Nanopillars and Nanotubes, Their Manufacture and Uses 有权
    聚合物纳米管和纳米管，其制造和用途

    公开(公告)号：US20100108519A1

    公开(公告)日：2010-05-06

    申请号：US12440546

    申请日：2007-09-12

    Applicant: Steven A. Soper ,  Robin L. McCarley ,  Guofang Chen ,  Hamed Shadpour

    Inventor： Steven A. Soper ,  Robin L. McCarley ,  Guofang Chen ,  Hamed Shadpour

    IPC: G01N27/26 ,  B82B3/00 ,  B32B5/16

    CPC classification number: B81C1/00111 ,  B81C2201/034 ,  G01N27/44773 ,  Y10T428/2982

    Abstract: A method is disclosed for fabricating free-standing polymeric nanopillars or nanotubes with remarkably high aspect ratios. The nanopillars and nanotubes may be used, for example, in integrated microfluidic systems for rapid, automated, high-capacity analysis or separation of complex protein mixtures or their enzyme digest products. One embodiment, preferably fabricated entirely from polymer substrates, comprises a cell lysis unit; a solid-phase extraction unit with free-standing, polymeric nanostructures; a multi-dimensional electrophoretic separation unit with high peak capacity; a solid-phase nanoreactor for the proteolytic digestion of isolated proteins; and a chromatographic unit for the separation of peptide fragments from the digestion of proteins. The nanopillars and nanotubes may also be used to increase surface area for reaction with a solid phase, for example, with immobilized enzymes or other catalysts within a microchannel, or as a solid support for capillary electrochromatography-based separations of proteins or peptides.

    Abstract translation: 公开了用于制造具有非常高的纵横比的独立聚合物纳米柱或纳米管的方法。 纳米管和纳米管可用于例如用于快速，自动化，高容量分析或分离复杂蛋白质混合物或其酶消化产物的集成微流体系统。 一个实施方案，优选完全由聚合物底物制造，包括细胞裂解单元; 具有独立的聚合物纳米结构的固相萃取装置; 具有高峰值容量的多维电泳分离单元; 用于分离蛋白质的蛋白水解消化的固相纳米反应器; 以及用于从蛋白质消化中分离肽片段的色谱单元。 纳米柱和纳米管也可用于增加与固相反应的表面积，例如固定化酶或微通道内的其它催化剂，或作为固体支持物，用于基于毛细管电色谱法的蛋白质或肽分离。

    Imprint lithographic method for making a polymeric structure
    182.
    发明授权
    Imprint lithographic method for making a polymeric structure 有权
    用于制造聚合物结构的印记平版印刷方法

    公开(公告)号：US07704432B2

    公开(公告)日：2010-04-27

    申请号：US11436833

    申请日：2006-05-18

    Applicant: Jarrett Dumond ,  Hong Yee Low

    Inventor： Jarrett Dumond ,  Hong Yee Low

    IPC: B28B3/06 ,  A61M25/00 ,  B29C59/02 ,  B28B7/10

    CPC classification number: A61M25/00 ,  B27N3/08 ,  B28B3/06 ,  B81C99/0085 ,  B81C2201/034 ,  B81C2203/032 ,  B81C2203/038 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  Y10T428/24479 ,  Y10T428/254

    Abstract: An imprint lithographic method for making a polymeric structure comprising the steps of: (a) providing a mold having a shape forming a mold pattern; (b) providing a substrate having a higher surface energy relative to said mold; (c) providing a polymer film on said mold, said polymer film having a selected thickness, wherein the selected thickness of the polymer film on the mold pattern is capable of forming at least one frangible region in the polymer film having a thickness that is less than the remainder of the polymer film; (d) pressing the mold and the substrate relatively toward each other to form said frangible region; and (e) releasing at least one of said mold and said substrate from the other, wherein after said releasing, said frangible region remains substantially attached to said mold while the remainder of said polymer film forms the polymeric structure attached to said substrate.

    Abstract translation: 一种用于制造聚合物结构的压印光刻方法，包括以下步骤：（a）提供具有形成模具图案的形状的模具; （b）提供相对于所述模具具有更高表面能的基底; （c）在所述模具上提供聚合物膜，所述聚合物膜具有选定的厚度，其中模具图案上的聚合物膜的选定厚度能够在聚合物膜中形成至少一个具有较小厚度的易碎区域 比其余的聚合物膜; （d）相对于彼此挤压模具和基板以形成所述易碎区域; 和（e）将所述模具和所述基材中的至少一个从另一个释放，其中在所述释放之后，所述易碎区保持基本上附着到所述模具，而所述聚合物膜的其余部分形成附着到所述基底的聚合物结构。

    Mold and molding apparatus using the same
    183.
    发明授权
    Mold and molding apparatus using the same 失效
    模具和使用它的成型装置

    公开(公告)号：US07678319B2

    公开(公告)日：2010-03-16

    申请号：US12024354

    申请日：2008-02-01

    Applicant: Junichi Seki ,  Tohru Den

    Inventor： Junichi Seki ,  Tohru Den

    IPC: B29C59/00

    CPC classification number: G03F7/0002 ,  B29C35/02 ,  B29C43/003 ,  B29C43/021 ,  B29C59/002 ,  B29C59/022 ,  B29C2043/025 ,  B29C2043/3634 ,  B29C2059/023 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y10/00 ,  B82Y40/00

    Abstract: A molding apparatus for patterning a workpiece includes a mold having a pattern to be transferred to the workpiece, with the pattern including recesses, a first support member for supporting the mold, and a second support member, arranged opposite to the first support member, for supporting the workpiece. A pressing mechanism brings the first and second support members close to each other and presses the mold and the workpiece together so as to transfer, to the workpiece, the pattern on the mold. Recessed portions are provided on at least one of a surface of the mold on the first support member side, a region of the first support member, and a region of the second support member. The recessed portions correspond to recesses in the pattern of the mold.

    Abstract translation: 用于图案化工件的成型装置包括具有要传送到工件的图案的模具，图案包括凹部，用于支撑模具的第一支撑构件和与第一支撑构件相对设置的第二支撑构件，用于 支撑工件。 按压机构使第一和第二支撑构件彼此靠近，将模具和工件一起压在一起，以将工件上的图案转印到模具上。 在第一支撑构件侧的模具的表面，第一支撑构件的区域和第二支撑构件的区域中的至少一个表面上设置嵌入部分。 凹部对应于模具图案中的凹部。

    Method for manufacturing microstructures having multiple microelements with through-holes
    186.
    发明授权
    Method for manufacturing microstructures having multiple microelements with through-holes 有权
    具有多个具有通孔的微量元素的微结构的制造方法

    公开(公告)号：US07578954B2

    公开(公告)日：2009-08-25

    申请号：US10373251

    申请日：2003-02-24

    Applicant: Vladimir Gartstein ,  Faiz Feisal Sherman

    Inventor： Vladimir Gartstein ,  Faiz Feisal Sherman

    IPC: B29C43/02 ,  B29C1/48

    CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B26F1/24 ,  B26F1/26 ,  B81B2201/055 ,  B81C2201/034 ,  B81C2201/036

    Abstract: A method is provided for manufacturing microstructures of the type which contain a substrate and an array of protruding microelements with through-holes, which are used in penetrating layers of skin. The microelements are embossed or pressed into an initial substrate structure, which in some embodiments is formed from extruded polymeric material, and in some cases from two layers of polymer that are co-extruded. The through-holes are formed from filled through-cylinders of a second material that is removed after the embossing or pressing step; in other instances, the through-holes are left hollow during the embossing or pressing step.

    Abstract translation: 提供了一种用于制造包含基底的微结构的方法和具有通孔的突出微元件阵列，其用于穿透皮肤层。 微元件被压花或压制成初始的基底结构，其在一些实施方案中由挤出的聚合物材料形成，并且在一些情况下由共挤出的两层聚合物形成。 通孔由在压花或压制步骤之后被去除的第二材料的填充的通孔形成; 在其他情况下，在压花或压制步骤期间，通孔留空。

    Aerogel-Bases Mold for MEMS Fabrication and Formation Thereof
    187.
    发明申请
    Aerogel-Bases Mold for MEMS Fabrication and Formation Thereof 有权
    用于MEMS制造和形成的基于气凝胶的模具

    公开(公告)号：US20090184088A1

    公开(公告)日：2009-07-23

    申请号：US12017944

    申请日：2008-01-22

    Applicant: Robert J. Carlson

    Inventor： Robert J. Carlson

    IPC: B29C33/56 ,  B29C41/00

    CPC classification number: B29C33/3842 ,  B29C41/00 ,  B29C59/14 ,  B29C59/16 ,  B29K2909/00 ,  B29K2995/0037 ,  B81B7/00 ,  B81B2201/05 ,  B81B2201/058 ,  B81B2203/0127 ,  B81C99/009 ,  B81C2201/0132 ,  B81C2201/0143 ,  B81C2201/034 ,  C23F1/02 ,  H01L21/30604 ,  Y10T428/24496

    Abstract: The invention is directed to a patterned aerogel-based layer that serves as a mold for at least part of a microelectromechanical feature. The density of an aerogel is less than that of typical materials used in MEMS fabrication, such as poly-silicon, silicon oxide, single-crystal silicon, metals, metal alloys, and the like. Therefore, one may form structural features in an aerogel-based layer at rates significantly higher than the rates at which structural features can be formed in denser materials. The invention further includes a method of patterning an aerogel-based layer to produce such an aerogel-based mold. The invention further includes a method of fabricating a microelectromechanical feature using an aerogel-based mold. This method includes depositing a dense material layer directly onto the outline of at least part of a microelectromechanical feature that has been formed in the aerogel-based layer.

    Abstract translation: 本发明涉及用作至少部分微机电特征的模具的图案化气凝胶基层。 气凝胶的密度小于MEMS制造中使用的典型材料的密度，例如多晶硅，氧化硅，单晶硅，金属，金属合金等。 因此，可以以明显高于在较致密的材料中形成结构特征的速率的速率在气凝胶层中形成结构特征。 本发明还包括一种图案化气凝胶层以产生这种基于气凝胶的模具的方法。 本发明还包括使用基于气凝胶的模具制造微机电特征的方法。 该方法包括将致密材料层直接沉积在已经形成在气凝胶层中的微机电特征的至少一部分的轮廓上。

    Micro-mechanical thermo structure and method for manufacturing such micro-mechanical structure
    188.
    发明授权
    Micro-mechanical thermo structure and method for manufacturing such micro-mechanical structure 失效
    微机械热结构及其制造方法

    公开(公告)号：US07538930B2

    公开(公告)日：2009-05-26

    申请号：US10539388

    申请日：2003-11-20

    Applicant: Dirk Jan Broer ,  Grietje Neeltje Mol ,  Christiane Maria Rosette De Witz

    Inventor： Dirk Jan Broer ,  Grietje Neeltje Mol ,  Christiane Maria Rosette De Witz

    IPC: G02F1/01 ,  G02B26/08

    CPC classification number: B29C37/0053 ,  B29C33/42 ,  B29C43/021 ,  B29C2035/0827 ,  B29L2011/0016 ,  B29L2031/756 ,  B81B3/0035 ,  B81B2201/047 ,  B81C2201/034

    Abstract: The invention relates to a micro-mechanical thermal structure for modulating a light beam and a method for manufacturing such a structure. The micro-mechanical structure comprises two layers of material with different thermal expansion coefficients in a first direction and a second direction respectively, in which the first direction is transverse to the second direction and the two layers comprise an oriented polymer and the director of the molecules of the oriented polymer of the first layer is transverse to the director of the molecules of the oriented polymer of the second layer. An array of such micro-mechanical structures may form a thermo-optical modulator for modulating light. The method comprises a step of providing a mold with an orientation-inducing layer to obtain a molecular orientation in a mono-meric state of liquid crystalline monomers and a step of fixing the molecular orientation by photo-polymerization.

    Abstract translation: 本发明涉及用于调制光束的微机械热结构及其制造方法。 微机械结构包括在第一方向和第二方向上分别具有不同热膨胀系数的两层材料，其中第一方向横向于第二方向，并且两层包括取向聚合物和分子的导向体 的第一层的取向聚合物横向于第二层的取向聚合物的分子的导向体。 这种微机械结构的阵列可以形成用于调制光的热光调制器。 该方法包括提供具有取向诱导层以获得液晶单体的单体状态的分子取向的模具和通过光聚合固定分子取向的步骤的步骤。

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