公开(公告)号：US09649059B2

公开(公告)日：2017-05-16

申请号：US14261043

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US09618391B2

公开(公告)日：2017-04-11

申请号：US14634364

申请日：2015-02-27

Applicant: Spectrasensors, Inc.

Inventor： Alfred Feitisch ,  Xiang Liu ,  Hsu-Hung Huang ,  Wenhai Ji ,  Richard L. Cline

IPC: G01J3/02 ,  G01N21/3504 ,  G01N21/05 ,  G01N21/27 ,  G01J3/42 ,  G01N21/39 ,  G01N21/03

CPC classification number: G01J3/0297 ,  G01J3/42 ,  G01N21/05 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/0314 ,  G01N2021/399 ,  G01N2201/1211 ,  G01N2201/1218 ,  G01N2201/127

Abstract: Validation verification data quantifying an intensity of light reaching a detector of a spectrometer from a light source of the spectrometer after the light passes through a validation gas across a known path length can be collected or received. The validation gas can include an amount of an analyte compound and an undisturbed background composition that is representative of a sample gas background composition of a sample gas to be analyzed using a spectrometer. The sample gas background composition can include one or more background components. The validation verification data can be compared with stored calibration data for the spectrometer to calculate a concentration adjustment factor, and sample measurement data collected with the spectrometer can be modified using this adjustment factor to compensate for collisional broadening of a spectral peak of the analyte compound by the background components. Related methods, articles of manufacture, systems, and the like are described.

公开(公告)号：US09599806B2

公开(公告)日：2017-03-21

申请号：US14734320

申请日：2015-06-09

Applicant: General Electric Company

Inventor： Zhangyi Zhong ,  Chun Zhan ,  Kang Zhang ,  Daniel Curtis Gray

IPC: G02B21/00 ,  G02B21/24 ,  G02B7/28 ,  G01B9/02 ,  G01N21/95 ,  G01N21/88

CPC classification number: G02B21/245 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02063 ,  G01B9/02091 ,  G01N21/8851 ,  G01N21/9501 ,  G01N2201/127 ,  G02B7/28 ,  G02B21/0016 ,  G02B21/0032 ,  G02B21/0056

Abstract: Methods and systems for autofocusing of an imaging system are presented. Provided is an imaging system and an optical interferometry system for generating one or more images corresponding to a target region in a subject. The method provides calibration information that identifies a focal position of the optical interferometry system corresponding to a determined focal position of the imaging system. A subsequent focal position of the imaging system is determined for generating a desired image corresponding to at least one of another target region in the subject and another position of the target region relative to the imaging system based on the calibration information.

公开(公告)号：US20170074856A1

公开(公告)日：2017-03-16

申请号：US15123334

申请日：2015-03-05

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： Igor Gofman

IPC: G01N33/487 ,  G01N21/78 ,  G01N27/327 ,  G01N33/49

CPC classification number: G01N33/48771 ,  G01N21/78 ,  G01N21/8483 ,  G01N27/3272 ,  G01N27/3274 ,  G01N33/49 ,  G01N2021/7759 ,  G01N2021/7786 ,  G01N2201/127

Abstract: A test sensor (100) for determining an analyte concentration in a biological fluid comprises a strip including a fluid receiving area (128) and a port-insertion region (126). A first row of optically transparent (132) and non-transparent positions forms a calibration code pattern (130) disposed within a first area of the port-insertion region (126). A second row of optically transparent (142) and non-transparent positions forms a synchronization code pattern (140) disposed within a second area of the port-insertion region (126). The second area is different from the first area. The synchronization code pattern (140) corresponds to the calibration code pattern (130) such that the synchronization code pattern (140) provides synchronization of the serial calibration code pattern (130) during insertion of the port-insertion region (126) into the receiving port of the analyte meter.

Abstract translation: 用于确定生物流体中的分析物浓度的测试传感器（100）包括包括流体接收区域（128）和端口插入区域（126）的条带。 光学透明（132）和非透明位置的第一行形成设置在端口插入区域（126）的第一区域内的校准码图案（130）。 光学透明（142）和非透明位置的第二行形成设置在端口插入区域（126）的第二区域内的同步码图案（140）。 第二个区域与第一个区域不同。 同步代码模式（140）对应于校准代码模式（130），使得同步代码模式（140）在将端口插入区域（126）插入到接收器中时提供串行校准代码模式（130）的同步 分析仪的端口。

公开(公告)号：US09562851B2

公开(公告)日：2017-02-07

申请号：US14648874

申请日：2013-12-04

Applicant: SP3H

Inventor： Sylvain Oberti ,  Johan Fournel

IPC: G01N21/3577 ,  G01N21/3504 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: The present invention relates to a method for controlling a spectrometer for analyzing a product, the spectrometer including a light source including several light-emitting diodes having respective emission spectra covering in combination an analysis wavelength band, the method including steps of: supplying at least one of the light-emitting diodes with a supply current to switch it on, measuring a light intensity emitted by the light source by measuring a current at a terminal of at least another of the light-emitting diodes maintained off, determining, according to each light intensity measurement, a setpoint value of the supply current of each diode that is on, and regulating the supply current of each diode that is on so that it corresponds to the setpoint value.

Abstract translation: 本发明涉及一种用于分析产品的光谱仪的控制方法，该光谱仪包括具有多个发光二极管的光源，该发光二极管具有组合分析波长带的各发射光谱，该方法包括以下步骤：将至少一个 的发光二极管与供电电流接通，通过测量至少另一个发光二极管的端子上的电流来测量由光源发射的光强度，根据每个光 强度测量，导通的每个二极管的电源电流的设定值，以及调节导通的每个二极管的电源电流，使其对应于设定值。

公开(公告)号：US20170003261A1

公开(公告)日：2017-01-05

申请号：US15200728

申请日：2016-07-01

Applicant: Ecolab USA Inc.

Inventor： Hui Li ,  Alexandra Knoth ,  Joe Schwartz ,  Christopher Brant Wilson ,  Arthur Kahaian

IPC: G01N33/18 ,  G01N21/64

CPC classification number: G01N33/1853 ,  C09B11/24 ,  C09B67/0083 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/645 ,  G01N33/1813 ,  G01N2201/127

Abstract: Disclosed are methods that can be used to automatically calibrate a fluorescence-measuring instrument capable of continuously measuring the concentration of hardness in process water. The calibration method is used to compensate for drift of instrument and equipment, changes of operational conditions, and contamination of reagents and calibration standards. Calibration of the fluorescence-measuring instrument using the present calibration method improves both accuracy and repeatability for subsequent hardness concentration measurements.

Abstract translation: 公开了可用于自动校准能够连续测量工艺水中硬度浓度的荧光测量仪器的方法。 校准方法用于补偿仪器和设备的漂移，操作条件的变化以及试剂污染和校准标准。 使用本校准方法校准荧光测量仪器可以提高后续硬度浓度测量的精度和重复性。

公开(公告)号：US09527049B2

公开(公告)日：2016-12-27

申请号：US13921455

申请日：2013-06-19

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Amy L. Hiddessen ,  Erin R. Chia

IPC: B01F5/00 ,  B01F9/00 ,  B01F11/00 ,  C12Q1/68 ,  G01N1/38 ,  B01L3/00 ,  B01F5/06 ,  B01F13/00 ,  G01N1/28

CPC classification number: C12Q1/6816 ,  B01F5/0085 ,  B01F5/0647 ,  B01F9/00 ,  B01F11/00 ,  B01F13/0062 ,  B01F13/0072 ,  B01F2215/0037 ,  B01L3/502784 ,  B01L3/52 ,  B01L2200/148 ,  B01L2200/185 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  C12Q1/6806 ,  G01N1/38 ,  G01N21/6428 ,  G01N21/645 ,  G01N2001/2893 ,  G01N2021/6439 ,  G01N2201/127 ,  C12Q2563/159

Abstract: Provided herein, are droplet mixture compositions and systems and methods for forming mixtures of droplets. The system may comprise two or more droplet generation units. Each unit may include at least one first input well, a second input well, and an output well connected to the first and second input wells by channels that form a droplet generator. The combined droplet populations can be mixed, heated, and collected for multiple uses, such as for use as calibration standards for instrument testing and analysis.

Abstract translation: 本文提供了液滴混合物组合物和用于形成液滴混合物的系统和方法。 该系统可以包括两个或更多个液滴产生单元。 每个单元可以包括至少一个第一输入井，第二输入井和通过形成液滴发生器的通道连接到第一和第二输入井的输出井。 组合的液滴种群可以混合，加热和收集用于多种用途，例如用作仪器测试和分析的校准标准。

公开(公告)号：US09513227B2

公开(公告)日：2016-12-06

申请号：US14409956

申请日：2014-04-21

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： Mari Onodera ,  Shin-ichi Imai ,  Hironori Kumagai

IPC: G01N31/00 ,  G01N35/02 ,  G01N21/75 ,  G01N21/78 ,  G01N21/31 ,  G01N31/22

CPC classification number: G01N21/75 ,  G01N21/31 ,  G01N21/78 ,  G01N31/005 ,  G01N31/228 ,  G01N2021/755 ,  G01N2201/061 ,  G01N2201/127

Abstract: The present invention provides a method for quantitative determination of oxidant which method is capable of accurately and rapidly performing quantitative determination of oxidant at low cost, and an apparatus for quantitative determination of oxidant used in the method. The method for quantitative determination of oxidant according to the present invention is a method for quantitative determination of oxidant performing quantitative determination of oxidant in a sample using a redox reaction, the method including: adding one kind of reducing agent to a sample solution containing one or a plurality of kinds of oxidants having different lifetimes; producing an absorbance curve by measuring a time change in absorbance of the post-color-change or post-coloring reducing agent; and performing the quantitative determination of the oxidant while identifying the oxidant in the sample solution based on the obtained absorbance curve.

Abstract translation: 本发明提供了一种用于定量测定氧化剂的方法，该方法能够以低成本准确且快速地进行氧化剂的定量测定，并且该方法中用于定量测定氧化剂的装置。 本发明的氧化剂的定量测定方法是使用氧化还原反应对样品中的氧化剂进行定量测定的氧化剂的定量测定方法，该方法包括：将一种还原剂加入到含有一种或多种 多种具有不同寿命的氧化剂; 通过测量后变色或后着色还原剂的吸光度的时间变化来产生吸光度曲线; 并且基于所获得的吸光度曲线，在确定样品溶液中的氧化剂的同时进行氧化剂的定量测定。

公开(公告)号：US09494526B2

公开(公告)日：2016-11-15

申请号：US13713595

申请日：2012-12-13

Applicant: Step Ahead Innovations, Inc.

Inventor： James E. Clark

IPC: F21V5/00 ,  G01N21/88 ,  G01N21/77 ,  C02F1/00 ,  G01N33/18 ,  G01N21/85 ,  G01N21/15 ,  F21V8/00 ,  G01N21/78 ,  G01N31/22 ,  A01K63/04 ,  G01N21/64

CPC classification number: G01N21/77 ,  A01K63/04 ,  C02F1/008 ,  C02F2103/42 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/008 ,  C02F2209/06 ,  C02F2209/14 ,  C02F2209/15 ,  C02F2209/18 ,  G01N21/15 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8507 ,  G01N21/88 ,  G01N31/22 ,  G01N33/18 ,  G01N2021/758 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/127 ,  G02B6/0001 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/175383 ,  Y10T436/193333 ,  Y10T436/207497 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Combined illuminator/light collectors (I/LCs) that provide measurement and/or reference light to a target and collect light from the target. One example of a use for a combined I/LC of the present disclosure is for an optic of an optical reader used to read one or more chemical indicators that undergo physical changes that can be optically detected. The combined I/LC includes a spot lensing designed and configured in conjunction with the target to provide spot illumination on the target from one or more light sources. A light collector collects light from the target resulting from the spot illumination. Some embodiments further include dispersive lensing to direct a portion of the light from each light source away from the spot illumination to keep that light from interfering with the spot illumination.

Abstract translation: 组合的照明器/集光器（I / LC），其向目标提供测量和/或参考光并从目标收集光。 用于本公开的组合I / LC的一个示例是用于读取一个或多个经历可被光学检测的物理变化的化学指示剂的光学读取器的光学元件。 组合的I / LC包括与目标结合设计和配置的点透镜，以从一个或多个光源在目标上提供斑点照明。 光收集器从点光照射中收集来自目标的光。 一些实施例还包括色散透镜以将来自每个光源的光的一部分引导离开光点照明，以保持该光不影响光点照明。

公开(公告)号：US20160320361A1

公开(公告)日：2016-11-03

申请号：US15105454

申请日：2014-12-12

Applicant: SIMTRONICS AS

Inventor： Ib-Rune JOHANSEN ,  Preben STORÅS ,  Matthieu LACOLLE ,  Dag Thorstein WANG ,  Arne KARLSSON ,  Jon Olav GREPSTAD ,  Arvid BJERKESTRAND

IPC: G01N33/00 ,  G01N21/64 ,  G01N21/17

CPC classification number: G01N33/0013 ,  G01N21/1702 ,  G01N21/3504 ,  G01N21/643 ,  G01N21/783 ,  G01N33/0006 ,  G01N33/0037 ,  G01N33/0042 ,  G01N33/0044 ,  G01N2021/1704 ,  G01N2201/0638 ,  G01N2201/0696 ,  G01N2201/127 ,  Y02A50/245

Abstract: The present invention relates to a gas detector cell and cell unit for optical detection of a predetermined gas, the cell being provided with optical means for investigating a gas sample present in the cell. The cell is constituted by a volume enclosed in a container, at least part of the container wall being constituted by a membrane, the membrane being provided with openings allowing diffusion of gas therethrough, and the membrane openings being provided with a catalyst for converting the gas diffusing therethrough to said predetermined gas.

Abstract translation: 本发明涉及用于光学检测预定气体的气体检测器单元和单元单元，该单元设置有用于调查存在于单元中的气体样品的光学装置。 电池由容纳在容器中的体积构成，容器壁的至少一部分由膜构成，膜具有允许气体扩散通过的开口，膜开口设置有用于转换气体的催化剂 扩散到所述预定气体。