公开(公告)号：US20100307929A1

公开(公告)日：2010-12-09

申请号：US12867964

申请日：2008-11-26

Applicant: Kexin Xu ,  Dachao Li

Inventor： Kexin Xu ,  Dachao Li

IPC: G01F1/64 ,  G01N33/53

CPC classification number: G01N33/66 ,  G01N29/036 ,  G01N33/5438 ,  G01N2291/0256 ,  G01N2291/0427

Abstract: Disclosed is a sensor for measuring the amount of an analyte to be detected in human interstitial fluid, comprising a micro-cantilever sensing unit which includes: a first substrate; a micro-cantilever which is substantially in parallel with the first substrate and one end of which is supported onto the first substrate; a gold film formed onto at least one side of the micro-cantilever; a protein layer formed on the gold film, the protein layer being used to adsorb, at a surface thereof, the analyte to be detected in human interstitial fluid; a driving electrode provided on the first substrate; a micro-cantilever electrode which is provided on the first substrate at a position where the micro-cantilever is supported, and which is cooperated with the driving electrode so as to drive the micro-cantilever to produce resonance in a direction perpendicular to the first substrate; and a detecting electrode which is provided on the first substrate and which is cooperated with the micro-cantilever electrode so as to detect resonance frequency of the micro-cantilever. The present invention also relates to a fluid channel unit, a sensor system, and a method for measuring the amount of an analyte to be detected in human interstitial fluid.

Abstract translation: 公开了一种用于测量人间质液中要检测的分析物的量的传感器，包括微悬臂感测单元，其包括：第一基板; 基本上与第一基板平行的微悬臂，其一端被支撑在第一基板上; 形成在微悬臂梁的至少一侧上的金膜; 形成在金膜上的蛋白质层，所述蛋白质层用于在其表面吸附要在人间质液中检测的分析物; 设置在所述第一基板上的驱动电极; 微悬臂电极，其设置在所述第一基板上的所述微悬臂支撑的位置处，并且与所述驱动电极配合，以便驱动所述微悬臂以在垂直于所述第一基板的方向上产生共振 ; 以及检测电极，其设置在所述第一基板上，并与所述微悬臂电极配合，以检测所述微悬臂的共振频率。 本发明还涉及一种流体通道单元，传感器系统和用于测量在人类间质液中待检测的分析物的量的方法。

公开(公告)号：US20100048671A1

公开(公告)日：2010-02-25

申请号：US11914389

申请日：2006-05-12

Applicant: Yun Qiu ,  Kexin Xu ,  Yingqiu Xie

Inventor： Yun Qiu ,  Kexin Xu ,  Yingqiu Xie

IPC: A61K31/7105 ,  C07H21/02 ,  C12N15/11

CPC classification number: C07K16/40 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/111

Abstract: The present invention relates to a newly discovered 44 kD isoform of Pim-1 kinase made in human cells, and to the gene and messenger RNA for the 44 kilodalton isoform. The invention further describes methods and compounds for treating, especially prostate and hematopoietic cancer, by inhibiting expression of the 44 kD isoform of Pim-1 kinase, or its ability to phosphorylate Etk kinase and breast cancer resistance protein (BCRP).

Abstract translation: 本发明涉及新发现的44kD同种型的人细胞中制备的Pim-1激酶，以及44千道尔顿同种型的基因和信使RNA。 本发明还描述了通过抑制Pim-1激酶的44kD同种型的表达或其使Etk激酶和乳腺癌抗性蛋白（BCRP）磷酸化的能力来治疗特别是前列腺和造血癌的方法和化合物。

公开(公告)号：US20060167347A1

公开(公告)日：2006-07-27

申请号：US10532669

申请日：2003-09-25

Applicant: Kexin Xu ,  Yiwen Ma ,  Renda Wang

Inventor： Kexin Xu ,  Yiwen Ma ,  Renda Wang

IPC: A61B5/00

CPC classification number: A61B5/0059 ,  G01J3/10 ,  G01J3/1256 ,  G01N21/359 ,  G01N2021/3144

Abstract: The present invention discloses a spectral measurement method via continuous light source and discrete light source, and a measurement instrument for non-invasive detection of human body tissue components. Said instrument includes an incident unit, a probe, a receiving unit and a data processing unit. Said composite spectral measurement method improves or strengthens the output light intensity at the wavelength that carries information of the target component within human body. It enables the spectral detection in the whole wavelength range, and thus significantly enhances the SNR of the detecting system. In the non-invasive detection instrument, light from both the continuous light source and discrete light source can be firstly selectively light-split by AOTF, or AOTF conducts light-splitting for the continuous light source, while the discrete light source LD is controlled by a spatial chopper. When data of the spectral curves achieved from said continuous light source and discrete light source are processed, data acquired under different measuring modes can be compared.

Abstract translation: 本发明公开了一种通过连续光源和离散光源的光谱测量方法，以及用于非侵入式检测人体组织成分的测量仪器。 所述仪器包括入射单元，探测器，接收单元和数据处理单元。 所述复合光谱测量方法改善或加强了携带人体内目标成分信息的波长处的输出光强度。 它能够在整个波长范围内进行光谱检测，从而显着提高检测系统的信噪比。 在非侵入式检测仪器中，来自连续光源和离散光源的光可以首先被AOTF选择性地光分裂，或者AOTF对连续光源进行光分裂，而离散光源LD由 空中砍刀 当从所述连续光源和离散光源获得的光谱曲线的数据被处理时，可以比较在不同测量模式下获得的数据。

公开(公告)号：US5757002A

公开(公告)日：1998-05-26

申请号：US704987

申请日：1996-08-29

Applicant: Yutaka Yamasaki ,  Hisashi Okuda ,  Koji Matsuoka ,  Kexin Xu

Inventor： Yutaka Yamasaki ,  Hisashi Okuda ,  Koji Matsuoka ,  Kexin Xu

IPC: A61B5/00 ,  G01N21/35 ,  G01N21/47

CPC classification number: G01N21/359 ,  A61B5/1455 ,  G01N21/4795 ,  G01N2201/1293

Abstract: A light source pa light of a plurality of wavelengths of a near infrared region, and a spectroscopic part selects a wavelength subjected to absorption by lactic acid as a measuring wavelength from measuring light of a plurality of wavelengths emitted from the light source part. A probe comes into contact with an organism measuring portion and irradiates the organism measuring portion with the measuring light of the wavelength selected by the spectroscopic part, while a photoreceiving part detects transmitted/scattered light of the measuring light incident upon the organism measuring portion. A light signal detected by the photoreceiving part is converted to absorbance in a signal processing part, so that the concentration of lactic acid is calculated by a host computer serving as an arithmetic-control part and displayed on a display part. No reagent is required, while difference between lactic acid concentrations varied with measuring portions can also be noninvasively measured.

Abstract translation: 近红外区域的多个波长的光源pa光，并且分光部从测量从光源部发射的多个波长的光中选择被乳酸吸收的波长作为测量波长。 探测器与有机体测量部分接触，并且利用由分光部分选择的波长的测量光照射生物体测量部分，而光接收部分检测入射到生物体测量部分上的测量光的透射/散射光。 由光接收部分检测到的光信号在信号处理部分被转换为吸光度，从而通过用作运算控制部分的主计算机计算出乳酸浓度，并显示在显示部分上。 不需要试剂，乳酸浓度随测量部分变化的差异也可以非侵入性地测量。

公开(公告)号：US5615009A

公开(公告)日：1997-03-25

申请号：US630974

申请日：1996-04-12

Applicant: Takeshi Sakura ,  Yutaka Yamasaki ,  Hiroko Kubo ,  Kexin Xu ,  Motonobu Shiomi

Inventor： Takeshi Sakura ,  Yutaka Yamasaki ,  Hiroko Kubo ,  Kexin Xu ,  Motonobu Shiomi

IPC: G01J3/28 ,  G01N21/27 ,  G01J3/42

CPC classification number: G01N21/274

Abstract: A method of quantitative analysis of a specific component of an object to be measured comprises steps of measuring an energy spectrum of light transmitted through or reflected from the object, dividing the energy spectrum into a plurality of wavelength domains, thereby obtaining a plurality of partial energy spectra, normalizing the plurality of partial energy spectra within each wavelength domain using an energy measured at a predetermined wavelength contained in each wavelength domain, and performing the quantative analysis by multivariate analysis using the plurality of partial energy spectra having been normalized.

Abstract translation: 对被测量物体的特定成分进行定量分析的方法包括以下步骤：测量透过物体或通过物体反射的光的能谱，将能谱分成多个波长域，从而获得多个部分能量 光谱，使用在每个波长域中包含的预定波长测量的能量对每个波长域内的多个部分能谱进行标准化，以及使用已经被归一化的多个部分能谱通过多变量分析进行定量分析。

公开(公告)号：US5602647A

公开(公告)日：1997-02-11

申请号：US562785

申请日：1995-11-27

Applicant: Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

Inventor： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

IPC: G01N21/27 ,  G01J3/42 ,  G01N21/03 ,  G01N21/31 ,  G01N21/39 ,  G01N21/59 ,  G01N21/00

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01J3/42 ,  G01N2021/3129 ,  G01N21/39 ,  G01N21/59 ,  G01N2201/066 ,  G01N2201/0668

Abstract: An apparatus and method for optically measuring concentrations of components allow enhancement in measurement accuracy of concentration. The apparatus includes a cell, a light irradiator, a photodetector, and an arithmetic unit. The cell presents different optical path lengths at different locations and is to contain a sample therein. The light irradiator, which includes a variable-wavelength laser generator and a measuring system composed of convex lenses, outputs a collimated, enlarged laser beam, and makes the laser beam incident upon the cell. The photodetector comprises a multiplicity of photodetectors arranged in parallel to the surface of the cell, so that it can detect intensity of rays of transmitted light that have traveled over different optical path lengths at positions of an equal distance from the cell. The arithmetic unit, receiving a signal from the individual photodetectors, calculates concentrations of components in the sample based on optimum optical path lengths for different wavelengths and values of transmitted light at positions of the optimum optical path lengths, and further outputs calculation results.

Abstract translation: 用于光学测量组分浓度的装置和方法允许增强浓度的测量精度。 该装置包括单元，光照射器，光电检测器和运算单元。 细胞在不同位置呈现不同的光程长度，并且其中包含样品。 包括可变波长激光发生器和由凸透镜组成的测量系统的光照射器输出准直的，放大的激光束，并使激光束入射到电池上。 光电检测器包括与电池表面平行设置的多个光电检测器，使得其可以检测在距离电池相等距离的位置处已经在不同光程长度上行进的透射光的光强。 运算单元接收来自各个光电检测器的信号，根据最佳光程长度的不同波长的最佳光路长度和最佳光路长度位置处的透射光值，计算样品中的成分浓度，并进一步输出计算结果。

公开(公告)号：US08996338B2

公开(公告)日：2015-03-31

申请号：US12996089

申请日：2009-06-03

Applicant: Kexin Xu ,  Wenliang Chen

Inventor： Kexin Xu ,  Wenliang Chen

IPC: G06F17/10 ,  G01N15/02 ,  G01N21/359 ,  A61B5/145

CPC classification number: G01N21/359 ,  A61B5/14532

Abstract: A method of detecting a concentration of a target component by using a reference wavelength includes: defining a wavelength at which a light intensity is insensitive to the variation of the target component concentration as a reference wavelength for the target component; detecting spectra at both the reference wavelength and a further measuring wavelength; processing the spectrum detected at the further measuring wavelength, with the spectrum detected at the reference wavelength as an inner reference, to obtain a characteristic spectrum including specific information of the target component; building a calibration model between the characteristic spectrum and the concentration of the target component; and determining the concentration of the target component based on the calibration model.

Abstract translation: 通过使用参考波长检测目标成分的浓度的方法包括：确定光强度对目标成分的作为参考波长的目标成分浓度的变化不敏感的波长; 在参考波长和另外的测量波长处检测光谱; 处理在另一测量波长处检测到的光谱，以在参考波长处检测的光谱作为内部参考，以获得包括目标分量的特定信息的特征谱; 在特征谱与目标成分浓度之间建立校准模型; 以及基于所述校准模型确定所述目标成分的浓度。

公开(公告)号：US20110131021A1

公开(公告)日：2011-06-02

申请号：US12996089

申请日：2009-06-03

Applicant: Kexin Xu ,  Wenliang Chen

Inventor： Kexin Xu ,  Wenliang Chen

IPC: G06F17/10

CPC classification number: G01N21/359 ,  A61B5/14532

Abstract: A method of detecting a concentration of a target component by using a reference wavelength comprises: defining a wavelength at which a light intensity is insensitive to the variation of the target component concentration as a reference wavelength for the target component; detecting spectra at both the reference wavelength and a further measuring wavelength; processing the spectrum detected at the further measuring wavelength, with the spectrum detected at the reference wavelength as an inner reference, to obtain a characteristic spectrum including specific information of the target component; building a calibration model between the characteristic spectrum and the concentration of the target component; and determining the concentration of the target component based on the calibration model.

Abstract translation: 通过使用参考波长检测目标成分的浓度的方法包括：定义光强对目标成分的基准波长的目标成分浓度的变化不敏感的波长; 在参考波长和另外的测量波长处检测光谱; 处理在另一测量波长处检测到的光谱，以在参考波长处检测的光谱作为内部参考，以获得包括目标分量的特定信息的特征谱; 在特征谱与目标成分浓度之间建立校准模型; 以及基于所述校准模型确定所述目标成分的浓度。

公开(公告)号：US20060092418A1

公开(公告)日：2006-05-04

申请号：US10528522

申请日：2003-09-24

Applicant: Kexin Xu ,  Qingjun Qiu ,  Yixiong Su

Inventor： Kexin Xu ,  Qingjun Qiu ,  Yixiong Su

IPC: G01N21/47 ,  A61B5/00 ,  G01J4/00

CPC classification number: A61B5/0059 ,  A61B2562/0242 ,  G01N21/49

Abstract: This invention relates to an optical detection method for non-contact measuring an object and separating the surface and deep information of a medium in an object. A light beam that irradiates on the object from an incident unit is received by a receiving unit and detected by a detector. The separation of the surface and deep information of the medium can be achieved by a measuring system, wherein the optical probes don't contact the object. In the present invention, the incident unit and receiving unit can be configured according to polarization method, optical baffle method, space imaging method and Brewster angle method etc.

Abstract translation: 本发明涉及一种用于非接触测量物体并分离物体中的介质的表面和深度信息的光学检测方法。 从入射单元照射在物体上的光束被接收单元接收并由检测器检测。 介质的表面和深度信息的分离可以通过测量系统来实现，其中光学探针不接触物体。 在本发明中，入射单元和接收单元可以根据偏振方法，光学挡板法，空间成像法和布鲁斯特方法等进行配置。

公开(公告)号：US6147749A

公开(公告)日：2000-11-14

申请号：US817085

申请日：1997-04-29

Applicant: Hiroko Kubo ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

Inventor： Hiroko Kubo ,  Yoshio Mitsumura ,  Harumi Uenoyama ,  Kexin Xu

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N33/48 ,  G01N21/00

CPC classification number: G01N21/27 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6825 ,  A61B5/6842 ,  A61B5/6843

Abstract: To project measuring light with good reproducibility onto the measuring part of a measured object so that measurement conditions can always be constant. An optical measuring apparatus is equipped with a spectroscopic analyzer that detects the spectral intensity of the reflected light of measuring light projected onto a human hand. Spectroscopic analyzer moves in the direction" of the X-axis, Y axis, and Z axis, and around the Z axis by a moving mechanism. During the registration of the measuring part of the human hand, a CCD camera takes a picture of the human hand, and the operator selects a part having a feature from the pattern of the taken image. During the spectrometry, the CCD camera again takes a picture of the human hand. The optical measuring apparatus then detects the registered feature part on the currently taken image, moves spectroscopic analyzer by moving mechanism, and projects measuring light onto the registered feature part.

Abstract translation: PCT No.PCT / JP96 / 02223 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT 1996年8月7日PCT PCT。 出版物WO97 / 06423 日期1997年2月20日将测量对象的重复性重新测量投影到测量对象的测量部位，以便测量条件始终保持不变。 光学测量装置配备有光谱分析仪，其检测投射到人手上的测量光的反射光的光谱强度。 光谱分析仪通过移动机构沿X轴，Y轴和Z轴方向移动，Z轴周围移动，在人体测量部位的配准期间，CCD摄像机拍摄 人手，操作员从拍摄图像的图案中选择具有特征的部分，在光谱测定期间，CCD照相机再次拍摄人手的照片，然后光学测量装置检测当前拍摄的注册特征部分 图像，通过移动机构移动光谱分析仪，并将测量光投射到注册的特征部分上。