公开(公告)号：US20220299796A1

公开(公告)日：2022-09-22

申请号：US17834191

申请日：2022-06-07

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Kelly Kayi Tallau ,  Angela Driver-Scott ,  Chung-Yuan Chiang

IPC: G02C7/04 ,  B29D11/00 ,  G02B1/14 ,  C09D133/02 ,  C09D177/06 ,  G02B1/04

Abstract: The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon. This method has a minimized adverse impact on the mechanical properties of silicone hydrogel lens body.

公开(公告)号：US20220281190A1

公开(公告)日：2022-09-08

申请号：US17750518

申请日：2022-05-23

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Sibichen J. Thekveli ,  Robert Carey Tucker ,  Jared Nelson

IPC: B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  C09D177/06

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

公开(公告)号：US20220137263A1

公开(公告)日：2022-05-05

申请号：US17572794

申请日：2022-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B05D5/00 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20210130648A1

公开(公告)日：2021-05-06

申请号：US17146181

申请日：2021-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US20220032564A1

公开(公告)日：2022-02-03

申请号：US17385987

申请日：2021-07-27

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Ciara Dauenhauer ,  Chung-Yuan Chiang ,  Paul William Oyler ,  Robert Carey Tucker

IPC: B29D11/00 ,  G02C7/04 ,  C09D133/10 ,  C09D133/08

Abstract: The invention is related to a coated contact lens, especially a coated silicone hydrogel contact lens, which comprises an anterior surface, an opposite posterior surface, and a layered structural configuration from the anterior surface to the posterior surface. The layered structural configuration comprises an outer anterior surface hydrogel layer, an inner layer, and an outer posterior surface hydrogel layer. The inner layer is a lens bulk material. The coated contact lens has a superior lens surface softness and a good lens surface hydrophilicity while optionally having a desirably-lower polyquaternium-1 uptake.

公开(公告)号：US20210129467A1

公开(公告)日：2021-05-06

申请号：US17142883

申请日：2021-01-06

Applicant: Alcon Inc.

Inventor： John Dallas Pruitt ,  Lynn Cook Winterton ,  Jared Nelson

IPC: B29D11/00 ,  A61K9/00 ,  G02B1/04

Abstract: The invention relates to a soft hydrogel contact lens, especially a silicone hydrogel contact lens, which has a capability of delivering a hydrophobic comfort agent into the eye of a wearer. The hydrophobic comfort agent includes without limitation a monoglyceride, a diglyceride, a triglyceride, a glycolipid, a glyceroglycolipid, a sphingolipid, a sphingo-glycolipid, a phospholipid, a fatty acid, a fatty alcohol, a hydrocarbon having a C12-C28 chain in length, a mineral oil, a silicone oil, or a mixture thereof. It can be released from the soft hydrogel contact lens into the eye of a wearer when being worn so as to strengthen and stabilize the tear film lipid layer and alleviate the dryness of the eye.

公开(公告)号：US11933941B2

公开(公告)日：2024-03-19

申请号：US17572794

申请日：2022-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  B05D5/00 ,  B29D11/00 ,  B29K105/00 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/04 ,  B05D1/18 ,  B05D1/38 ,  B05D3/00 ,  B05D3/02 ,  B05D5/10 ,  B29K83/00

CPC classification number: G02B1/043 ,  B05D5/00 ,  B29D11/00038 ,  B29D11/00125 ,  B29D11/00865 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/049 ,  B05D1/18 ,  B05D1/38 ,  B05D3/002 ,  B05D3/02 ,  B05D5/10 ,  B29K2083/00 ,  B29K2105/0061 ,  C08L2201/10 ,  C08L2201/54 ,  G02B2207/109 ,  G02B1/043 ,  C08L83/04

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US11648583B2

公开(公告)日：2023-05-16

申请号：US16843989

申请日：2020-04-09

Applicant: Alcon Inc.

Inventor： Newton T. Samuel ,  Yongxing Qiu ,  John Dallas Pruitt ,  Matthew McCollum

IPC: B05D1/18 ,  G02B1/18 ,  C09D5/00 ,  C09D133/02 ,  B05D3/02 ,  B05D3/10 ,  G02C7/04

CPC classification number: B05D1/18 ,  B05D3/0209 ,  B05D3/107 ,  C09D5/002 ,  C09D133/02 ,  G02B1/18 ,  B05D2258/00 ,  B05D2401/20 ,  B05D2401/21 ,  B05D2502/00 ,  G02C7/04

Abstract: The invention is generally related to a method for producing, in a consistent manner, contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material having azetidinium groups onto a base coating of a polyanionic polymer on a contact lens at a relatively low temperature (e.g., from about 40° C. to about 60° C.). The coating temperature for forming a durable hydrogel coating on top of the base coating of a contact lens can be significantly lowered by raising, in situ, the pH (to about 9.5 or higher) of a reactive coating solution which contains the hydrophilic polymeric material having azetidinium groups.

公开(公告)号：US11534994B2

公开(公告)日：2022-12-27

申请号：US17146181

申请日：2021-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: B29D11/00 ,  G02B1/18 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  C09D177/06

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US10781340B2

公开(公告)日：2020-09-22

申请号：US16582624

申请日：2019-09-25

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Sibichen J. Thekveli ,  Robert Carey Tucker ,  Jared Nelson

IPC: C09D171/02 ,  C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.