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公开(公告)号：US08889871B2
公开(公告)日：2014-11-18
申请号：US14183247
申请日：2014-02-18
Applicant: Bristol-Myers Squibb Company
Inventor： Alan Xiangdong Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Yan Chen
IPC: C07D217/24 , C07D401/12
CPC classification number: A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
Abstract translation: 公开了具有以下通式的丙型肝炎病毒抑制剂：其中R1，R2，R3，R'，B，Y和X在说明书中描述。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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12.发明授权C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity 有权具有HIV成熟抑制活性的三萜类化合物的C-17二环胺公开(公告)号：US08889854B2
公开(公告)日：2014-11-18
申请号：US13799479
申请日：2013-03-13
Applicant: Bristol-Myers Squibb Company
Inventor： Ny Sin , Zheng Liu , Jacob Swidorski , Sing-Yuen Sit , Jie Chen , Yan Chen , Nicholas A. Meanwell , Alicia Regueiro-Ren
IPC: C07J53/00 , C07D498/08 , C07D495/08 , C07D495/10 , C07D487/10 , C07J63/00 , C07D491/08 , C07D209/52 , C07D487/08
CPC classification number: C07D487/08 , C07D209/52 , C07D487/10 , C07D491/08 , C07D495/08 , C07D495/10 , C07D498/08 , C07J63/008
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 bicyclic amines of triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的三萜类化合物的C-17二环胺作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。
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公开(公告)号：US12157733B2
公开(公告)日：2024-12-03
申请号：US17116016
申请日：2020-12-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US11618753B2
公开(公告)日：2023-04-04
申请号：US16963886
申请日：2019-01-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Carolyn Diane Dzierba , Hua Gong , Jason M. Guernon , Junqing Guo , Amy C. Hart , Guanglin Luo , John E. Macor , William J. Pitts , Jianliang Shi , Brian Lee Venables , Carolyn A. Weigelt , Yong-Jin Wu , Zhizhen Barbara Zheng , Sing-Yuen Sit , Jie Chen
IPC: A61K31/53 , C07D253/08 , C07D487/04
Abstract: The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.
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公开(公告)号：US20220380355A1
公开(公告)日：2022-12-01
申请号：US17762771
申请日：2020-10-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jie Chen , Carolyn Diane Dzierba , Junqing Goo , Amy C. Hart , William J. Pitts , Sing-Yuen Sit
IPC: C07D409/04 , C07D417/04 , C07D403/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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Patent Agency Ranking
16.发明申请COMPOSITIONS HAVING C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY 审中-公开具有HIV成熟抑制活性的C-17和C-3修饰的TRIPRPENOIDS的组合物公开(公告)号：US20140343000A1
公开(公告)日：2014-11-20
申请号：US14339572
申请日：2014-07-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
CPC classification number: A61K31/565 , A61K31/56 , A61K31/58 , A61K31/704 , A61K45/06 , C07J63/008
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-17和C-3修饰的三萜类化合物作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。
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公开(公告)号：US09636375B2
公开(公告)日：2017-05-02
申请号：US14936419
申请日：2015-11-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alan Xiangdong Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Yan Chen
IPC: A61K31/40 , A61K38/06 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/062 , C07K5/083 , C07K5/08 , C07D217/24 , A61K45/06 , A61K38/00
CPC classification number: A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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18.发明申请COMPOSITIONS HAVING C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY 审中-公开具有HIV成熟抑制活性的C-17和C-3修饰的TRIPRPENOIDS的组合物公开(公告)号：US20160151387A1
公开(公告)日：2016-06-02
申请号：US15015741
申请日：2016-02-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
IPC: A61K31/565 , A61K31/58 , A61K31/704 , A61K45/06
CPC classification number: A61K31/565 , A61K31/56 , A61K31/58 , A61K31/704 , A61K45/06 , C07J63/008
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-17和C-3修饰的三萜类化合物作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。
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公开(公告)号：US20140243298A1
公开(公告)日：2014-08-28
申请号：US14186533
申请日：2014-02-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jacob Swidorski , Yan Chen , Sing-Yuen Sit , Nicholas A. Meanwell , Alicia Regueiro-Ren , Jie Chen
IPC: C07J53/00 , A61K31/568 , A61K31/58
CPC classification number: C07J53/002 , A61K31/568 , A61K31/58 , C07J63/008
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:a compound of Formula I a compound of Formula II a compound of Formula III and a compound of Formula IV These compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的烷基和烯基C-3修饰的桦木酸衍生物作为HIV成熟抑制剂提供，如式I，II，III和IV化合物所示：式I化合物式IIa化合物 式III化合物和式IV化合物这些化合物可用于治疗艾滋病毒和艾滋病。
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公开(公告)号：US08710229B2
公开(公告)日：2014-04-29
申请号：US13901637
申请日：2013-05-24
Applicant: Bristol-Myers Squibb Company
Inventor： Alan Xiangdong Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Yan Chen
IPC: C07D215/38
CPC classification number: A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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