公开(公告)号：US20180169307A1

公开(公告)日：2018-06-21

申请号：US15843673

申请日：2017-12-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Mary M. Byron ,  David R. Wulfman ,  Angelo Fruci ,  Adam McGraw ,  Danielle Frankson ,  Gregory J. Sherwood ,  Joseph T. Delaney, JR. ,  Adeniyi O. Aremu

IPC: A61L31/16 ,  A61N1/05 ,  A61L31/14 ,  A61L31/04

Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.

公开(公告)号：US20180169306A1

公开(公告)日：2018-06-21

申请号：US15840815

申请日：2017-12-13

Applicant: Cardiac Pacemakers, Inc.

Inventor： Angelo Fruci ,  Arthur J. Foster ,  Joseph T. Delaney, JR. ,  Danielle Frankson

IPC: A61L31/16 ,  A61N1/05 ,  A61N1/375 ,  A61L31/06

Abstract: An implantable medical electrical lead is connectable to an electrical header of an implantable pulse generator. The lead includes a lead body, at least one electrode, a lead terminal, and a lead boot. The lead body extends from a proximal end to a distal end. The at least one electrode is disposed at the distal end of the lead body. The lead terminal is disposed at the proximal end of the lead body and configured to connect the lead to the electrical header. The lead boot is formed of an elastic polymer infused with at least one antibiotic drug. A portion of the lead boot is configured to be disposed within the electrical header when the lead is connected to the electrical header.

公开(公告)号：US20180043064A1

公开(公告)日：2018-02-15

申请号：US15672674

申请日：2017-08-09

Applicant: Cardiac Pacemakers, Inc.

Inventor： David R. Wulfman ,  Danielle Frankson ,  Adeniyi O. Aremu ,  Angelo Fruci ,  Gregory J. Sherwood ,  Mary M. Byron ,  Joseph T. Delaney, JR. ,  Adam McGraw

IPC: A61L29/16 ,  A61F2/30 ,  A61L27/28

CPC classification number: A61L29/16 ,  A61F2/30767 ,  A61F2002/30677 ,  A61L27/28 ,  A61L31/046 ,  A61L31/06 ,  A61L31/10 ,  A61L2300/606 ,  A61L2400/12 ,  C08L71/02 ,  C08L75/04 ,  C08L27/12

Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

公开(公告)号：US20170361061A1

公开(公告)日：2017-12-21

申请号：US15623003

申请日：2017-06-14

Applicant: Cardiac Pacemakers, Inc.

Inventor： Danielle Frankson ,  Gregory J. Sherwood ,  David R. Wulfman ,  Kenneth Gunter ,  Angelo Fruci ,  Adam McGraw ,  Mary M. Byron

IPC: A61M25/00 ,  A61L2/02

CPC classification number: A61M25/0009 ,  A61L2/02 ,  A61L27/50 ,  A61L29/14 ,  A61L2400/18 ,  A61L2420/02

Abstract: This disclosure is directed to a medical device including a surface that has been roughened to provide a roughened surface that inhibits the adhesion of microorganisms on the roughened surface.

公开(公告)号：US09368925B2

公开(公告)日：2016-06-14

申请号：US14082516

申请日：2013-11-18

Applicant: Cardiac Pacemakers, Inc.

Inventor： Lily Lim ,  Ronald W. Kunkel ,  Joseph C. Walker ,  Peter C. Hall ,  Steven E. Schultz ,  Devon N. Arnholt ,  Angelo Fruci

IPC: H01R24/04 ,  H01R24/58 ,  A61N1/375 ,  H01R43/00

CPC classification number: H01R24/58 ,  A61N1/3752 ,  H01R43/00 ,  Y10T29/49171 ,  Y10T29/49172 ,  Y10T29/49208

Abstract: An IS-4 terminal connector assembly includes three terminal electrodes positioned over an inner tubular member such that they are radially offset from one another. Each of the terminal ring electrodes are configured such that they can withstand both tensile and cyclical bending loads with minimal compromise in their outer geometry. Additionally, each of the terminal electrodes is configured such that they have both an inner and outer geometry that facilitates adequate insulation between a select terminal electrode and an adjacent conductor. Additionally, each of the terminal ring electrodes is configured such that they facilitate an external approach to staking a cable conductor.

公开(公告)号：US20140142670A1

公开(公告)日：2014-05-22

申请号：US14085735

申请日：2013-11-20

Applicant: Cardiac Pacemakers, Inc.

Inventor： Rajesh Radhakrishnan ,  Mary M. Byron ,  Angelo Fruci ,  Brian Vance

IPC: A61N1/05 ,  H01J9/02

CPC classification number: A61N1/05 ,  A61B5/042 ,  A61N1/056 ,  H01J9/02

Abstract: Various embodiments concern an electrode of an implantable medical device for delivering electrical stimulation to tissue. Such an electrode can include a main body formed from a substrate metal comprising one of titanium, stainless steel, a cobalt-chromium alloy, or palladium. The main body may not be radiopaque. The electrode may further include a first coating on at least one side of the main body, the first coating comprising a layer of one of tantalum or iridium metal that is at least about 2 micrometers thick. The first coating can be radiopaque and porous. The porosity of the first coating can increase the electrical performance of the electrode in delivering electrical stimulation to tissue.

Abstract translation: 各种实施例涉及用于将电刺激递送至组织的可植入医疗装置的电极。 这种电极可以包括由包括钛，不锈钢，钴 - 铬合金或钯中的一种的基底金属形成的主体。 主体可能不是不透射线的。 所述电极还可以包括在所述主体的至少一侧的第一涂层，所述第一涂层包含至少约2微米厚的钽或铱金属之一的层。 第一个涂层可以是不透射线和多孔的。 第一涂层的孔隙度可以增加电极在向组织递送电刺激时的电性能。