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公开(公告)号：US20180169307A1
公开(公告)日：2018-06-21
申请号：US15843673
申请日：2017-12-15
Applicant: Cardiac Pacemakers, Inc.
Inventor： Mary M. Byron , David R. Wulfman , Angelo Fruci , Adam McGraw , Danielle Frankson , Gregory J. Sherwood , Joseph T. Delaney, JR. , Adeniyi O. Aremu
Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.
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公开(公告)号：US20180043064A1
公开(公告)日：2018-02-15
申请号：US15672674
申请日：2017-08-09
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Danielle Frankson , Adeniyi O. Aremu , Angelo Fruci , Gregory J. Sherwood , Mary M. Byron , Joseph T. Delaney, JR. , Adam McGraw
CPC classification number: A61L29/16 , A61F2/30767 , A61F2002/30677 , A61L27/28 , A61L31/046 , A61L31/06 , A61L31/10 , A61L2300/606 , A61L2400/12 , C08L71/02 , C08L75/04 , C08L27/12
Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.
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公开(公告)号：US20170361061A1
公开(公告)日：2017-12-21
申请号：US15623003
申请日：2017-06-14
Applicant: Cardiac Pacemakers, Inc.
Inventor： Danielle Frankson , Gregory J. Sherwood , David R. Wulfman , Kenneth Gunter , Angelo Fruci , Adam McGraw , Mary M. Byron
CPC classification number: A61M25/0009 , A61L2/02 , A61L27/50 , A61L29/14 , A61L2400/18 , A61L2420/02
Abstract: This disclosure is directed to a medical device including a surface that has been roughened to provide a roughened surface that inhibits the adhesion of microorganisms on the roughened surface.
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公开(公告)号：US20220211919A1
公开(公告)日：2022-07-07
申请号：US17701421
申请日：2022-03-22
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Danielle Frankson , Adeniyi O. Aremu , Angelo Fruci , Gregory J. Sherwood , Mary M. Byron , Joseph T. Delaney, JR. , Adam McGraw
Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.
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公开(公告)号：US11324860B2
公开(公告)日：2022-05-10
申请号：US15672674
申请日：2017-08-09
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Danielle Frankson , Adeniyi O. Aremu , Angelo Fruci , Gregory J. Sherwood , Mary M. Byron , Joseph T. Delaney, Jr. , Adam McGraw
Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.
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Patent Agency Ranking
公开(公告)号：US10335513B2
公开(公告)日：2019-07-02
申请号：US15624102
申请日：2017-06-15
Applicant: Cardiac Pacemakers, Inc.
Inventor： Danielle Frankson , Joseph T. Delaney, Jr. , Mary M. Byron , Adam McGraw , David R. Wulfman , Kylee M. Lersch
Abstract: A coating for a roughened metal surface of an implantable medical device includes a poly(ethylene glycol) disposed on at least a portion of the roughened metal surface, wherein the poly(ethylene glycol) is covalently bonded directly to the roughened metal surface.
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公开(公告)号：US11660379B2
公开(公告)日：2023-05-30
申请号：US17701421
申请日：2022-03-22
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Danielle Frankson , Adeniyi O. Aremu , Angelo Fruci , Gregory J. Sherwood , Mary M. Byron , Joseph T. Delaney, Jr. , Adam McGraw
IPC: A61L24/00 , B05D3/00 , A61L29/16 , A61L31/06 , A61L31/04 , A61L31/10 , B05D3/06 , B05D3/10 , A61F2/30 , A61L27/28 , B05D3/02
CPC classification number: A61L29/16 , A61F2/30767 , A61L27/28 , A61L31/046 , A61L31/06 , A61L31/10 , B05D3/007 , B05D3/061 , B05D3/108 , A61F2002/30677 , A61L2300/606 , A61L2400/12 , A61L2420/02 , A61M2207/00 , B05D3/0254 , B05D2518/00 , A61L31/10 , C08L71/02 , A61L31/06 , C08L75/04 , A61L31/046 , C08L27/12
Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.
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公开(公告)号：US10518004B2
公开(公告)日：2019-12-31
申请号：US15843673
申请日：2017-12-15
Applicant: Cardiac Pacemakers, Inc.
Inventor： Mary M. Byron , David R. Wulfman , Angelo Fruci , Adam McGraw , Danielle Frankson , Gregory J. Sherwood , Joseph T. Delaney, Jr. , Adeniyi O. Aremu
Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.
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公开(公告)号：US20180043056A1
公开(公告)日：2018-02-15
申请号：US15673274
申请日：2017-08-09
Applicant: Cardiac Pacemakers, Inc.
Inventor： Danielle Frankson , Joseph T. Delaney, JR. , David R. Wulfman , Adam McGraw , Sarah M. Gruba
CPC classification number: A61L27/12 , A61F2/86 , A61L27/04 , A61L27/047 , A61L27/06 , A61L27/34 , A61L27/54 , A61L2300/102 , A61L2300/214 , A61L2300/404 , A61L2300/412 , C08L71/02
Abstract: A coating for a metal surface, the coating including poly(ethylene glycol) disposed on and covalently bonded directly to at least a portion of the metal surface, and a functional group grafted to at least a portion of the poly(ethylene glycol). The functional group is one of a bioactive functional group and an antimicrobial functional group.
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公开(公告)号：US20170360987A1
公开(公告)日：2017-12-21
申请号：US15624102
申请日：2017-06-15
Applicant: Cardiac Pacemakers, Inc.
Inventor： Danielle Frankson , Joseph T. Delaney, JR. , Mary M. Byron , Adam McGraw , David R. Wulfman , Kylee M. Lersch
IPC: A61L27/34 , C09D5/16 , C09D123/06
CPC classification number: A61L27/34 , A61L27/04 , A61L27/06 , A61L31/022 , A61L31/10 , A61L2400/18 , A61L2420/02 , C09D5/1681 , C09D123/06 , C08L71/02
Abstract: A coating for a roughened metal surface of an implantable medical device includes a poly(ethylene glycol) disposed on at least a portion of the roughened metal surface, wherein the poly(ethylene glycol) is covalently bonded directly to the roughened metal surface.
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