公开(公告)号：US20150008313A1

公开(公告)日：2015-01-08

申请号：US14368686

申请日：2012-12-04

Applicant: DH Technologies Development Pte. Ltd. ,  National Research Council of Canada

Inventor： Alexandre V. Loboda ,  Paul Corkum ,  David Rayner

IPC: H01J49/14 ,  H01J49/00 ,  H01J49/04 ,  H01J49/26

CPC classification number: H01J49/14 ,  H01J49/0031 ,  H01J49/0422 ,  H01J49/164 ,  H01J49/26

Abstract: The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 TW/cm2 to about 1000 TW/cm2) to ionize an analyte an ambient pressure greater than about 10−5 Torr (e.g., an ambient pressure in a range of about 1 atmosphere to about 100 atmospheres).

Abstract translation: 本公开通常提供用于质谱法的电离方法和装置。 在一些实施方案中，电离方法和装置在高强度下使用短激光脉冲（例如，具有约2fs至约1ps范围内的脉冲宽度的脉冲）（例如，在约1TT / cm 2至约1W / cm 2的范围内的强度 约1000TT / cm 2）以使分析物离子化大于约10 -5乇的环境压力（例如，约1大气压至约100大气压的环境压力）。

公开(公告)号：US20140339414A1

公开(公告)日：2014-11-20

申请号：US14369932

申请日：2012-11-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Alexandre V. Loboda

IPC: H01J49/06 ,  H01J49/26

CPC classification number: H01J49/066 ,  H01J49/26

Abstract: Systems and related methods are disclosed herein that generally involve focusing dispersed ions using one or more DC ion funnels. In some embodiments, a DC ion funnel is provided that includes a plurality of ring-shaped electrodes, each having an aperture formed therein such that the funnel defines an interior volume extending between an ion inlet and an ion outlet. A controller applies a DC potential to each of the electrodes without applying an RF potential to any of the electrodes, such that ions entering the funnel are substantially confined within said volume. The interior volume can have any of a variety of shapes, such as cylindrical, frusto-conical, and curved frusto-conical. In addition, any of a variety of DC potentials can be applied to the plurality of electrodes.

Abstract translation: 本文公开的系统和相关方法通常涉及使用一个或多个DC离子漏斗聚焦分散的离子。 在一些实施例中，提供了DC离子漏斗，其包括多个环形电极，每个电极具有形成在其中的孔，使得漏斗限定在离子入口和离子出口之间延伸的内部容积。 控制器将DC电位施加到每个电极，而不对任何电极施加RF电势，使得进入漏斗的离子基本上被限制在所述体积内。 内部容积可以具有各种形状，例如圆柱形，截头圆锥形和弯曲的截头圆锥形。 此外，可以对多个电极施加各种DC电位中的任何一个。