公开(公告)号：US20190153640A1

公开(公告)日：2019-05-23

申请号：US16308536

申请日：2017-06-12

Applicant: Duke University ,  North Carolina State University

Inventor： Howard Levinson ,  James Brian Davis ,  Don Ward ,  Jon Rust

IPC: D04B21/12

Abstract: A warp knitted fabric formed by a warp knitting machine includes a first knitted portion formed using a first knitting sequence in a machine direction, the first knitted portion comprises at least two strips extending in the machine direction, the at least two strips being detached from one another along their lengthwise edges. The second knitted portion has the same width as the first knitted portion, and the first knitted portion and the second knitted portion alternate sequentially in the machine direction and are formed of a single set of continuous textile strands.

公开(公告)号：US09823127B2

公开(公告)日：2017-11-21

申请号：US14683066

申请日：2015-04-09

Applicant: Duke University

Inventor： Adam Wax ,  Howard Levinson ,  William J. Brown ,  Thomas Matthews ,  Manuel Medina

IPC: G01J3/28 ,  G01B9/02 ,  G01J3/453 ,  G01N21/45 ,  G01J3/02 ,  A61B5/00 ,  G01N21/47

CPC classification number: G01J3/2823 ,  A61B5/445 ,  G01B9/02044 ,  G01B9/02091 ,  G01J3/0218 ,  G01J3/453 ,  G01J3/4531 ,  G01N21/45 ,  G01N21/4795

Abstract: Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an illumination beam, an interferometer, and a spectrometer. The interferometer includes a first beam splitter configured to split the illumination beam into an incident beam and a reference beam; an optical lens directs the incident beam onto a biological sample at a predefined offset from corresponding optical axis, and receive a beam scattered from the biological sample. The beams are configured to intersect with each other within a focal zone of the optical lens. Photons of the incident beam undergo multiple forward scattering within the biological sample. A second beam splitter configured to receive and superimpose the scattered and reference beams, to generate an interference beam. The spectrometer uses a spectral domain detection technique to assess tissue properties of the biological sample.

公开(公告)号：US20170290650A1

公开(公告)日：2017-10-12

申请号：US15508545

申请日：2015-09-04

Applicant: Duke University

Inventor： Howard Levinson

IPC: A61F2/00 ,  A61F2/12

CPC classification number: A61F2/0063 ,  A61F2/12 ,  A61F2002/0068 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body. Each mesh extension is configured to permit multiple anchor points with surrounding tissue upon implantation. In one embodiment, a fixation device is at the second end of each mesh extension. Methods of using the implantable mesh are also provided.

公开(公告)号：US11001948B2

公开(公告)日：2021-05-11

申请号：US16308536

申请日：2017-06-12

Applicant: Duke University ,  North Carolina State University

Inventor： Howard Levinson ,  James Brian Davis ,  Don Ward ,  Jon Rust

IPC: D04B21/12

Abstract: A warp knitted fabric formed by a warp knitting machine includes a first knitted portion formed using a first knitting sequence in a machine direction and a formed using a second knitted portion formed using a second knitting sequence in the machine direction, the second knitted portion comprising at least two strips extending in the machine direction, the at least two strips being detached from one another along their lengthwise edges. The second knitted portion has the same width as the first knitted portion, and the first knitted portion and the second knitted portion alternate sequentially in the machine direction and are formed of a single set of continuous textile strands.

公开(公告)号：US20190167260A1

公开(公告)日：2019-06-06

申请号：US16323656

申请日：2017-08-08

Applicant: Duke University

Inventor： Howard Levinson ,  Kenneth A. Gall

IPC: A61B17/04 ,  A61L31/04 ,  A61L31/14

Abstract: A fixation device is disclosed. The fixation device includes a first component and a second component. The first component has a top surface, a base, at least one locking projection, and at least one tapered projection extending from the top surface. The at least one locking projection includes a first locking element. The fixation device further includes a second component having a top surface, a base, at least one locking aperture, and at least one second aperture corresponding to the projections on the first component. The at least one locking apertures includes a second locking element. In some embodiments, the at least one locking projection on the first component is configured to lock together with the at least one locking aperture on the second component to secure together two ends of a surgical mesh suture or tape suture.

公开(公告)号：US20180289924A1

公开(公告)日：2018-10-11

申请号：US15769592

申请日：2016-10-28

Applicant: Duke University

Inventor： Vrad W. Levering ,  Changyong Cao ,  Gabriel P. Lopez ,  Xuanhe Zhao ,  Howard Levinson

IPC: A61M25/00

Abstract: Catheters for debonding fouling agents from an interior surface thereof and related methods are disclosed. According to an aspect, a catheter includes a lumen defining a flexible, interior surface that extends substantially along a length of the lumen for contacting a biological material. The catheter also includes cavities extending along the length and positioned within the lumen adjacent to the surface. The cavities each define a cavity opening. The catheter also includes an inflation hub defining hub openings connected to respective cavity openings. The inflation hub defines a pump port configured to interface with a pump. The inflation hub defines one or more fluid pathways that extend between the hub openings and the pump port for permitting flow of gas between the pump and the cavities.

公开(公告)号：US20170304488A1

公开(公告)日：2017-10-26

申请号：US15526259

申请日：2015-11-11

Applicant: Duke University

Inventor： Howard Levinson ,  Kam W. Leong ,  Elizabeth R. Lorden ,  Kyle J. Miller

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/34 ,  C08L67/04 ,  A61L27/58 ,  A61L27/00

CPC classification number: A61L27/18 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  C08L67/04

Abstract: The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.

公开(公告)号：US20150237837A1

公开(公告)日：2015-08-27

申请号：US14408902

申请日：2013-06-18

Applicant: Duke University

Inventor： Howard Levinson

IPC: A01K67/027

CPC classification number: A01K67/027 ,  A01K2207/30 ,  A01K2207/35 ,  A01K2227/105 ,  A01K2267/03

Abstract: The present disclosure provides a rodent scar contracture model to study scar contractures and methods of using such a model. Such uses may include, but are not limited to, testing mechanisms or action or developing new anti-scar contracture compounds.

Abstract translation: 本公开提供了一种用于研究瘢痕挛缩的啮齿动物瘢痕挛缩模型和使用这种模型的方法。 这些用途可以包括但不限于测试机制或作用或开发新的抗瘢痕挛缩化合物。