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    Methods for collection, dark correction, and reporting of spectra from array detector spectrometers
    11.
    发明授权
    Methods for collection, dark correction, and reporting of spectra from array detector spectrometers 有权

    公开(公告)号：US10048128B2

    公开(公告)日：2018-08-14

    申请号：US14950598

    申请日：2015-11-24

    Applicant: Kaiser Optical Systems Inc.

    Inventor： Patrick Wiegand ,  James M. Tedesco ,  Joseph B. Slater ,  Francis Esmonde-White ,  Darren Schipper

    IPC: G01J3/02 ,  G01J3/44 ,  G01J3/28 ,  G01N21/65

    Abstract: Methods and systems for spectrometer dark correction are described which achieve more stable baselines, especially towards the edges where intensity correction magnifies any non-zero results of dark subtraction, and changes in dark current due to changes in temperature of the camera window frame are typically more pronounced. The resulting induced curvature of the baseline makes quantitation difficult in these regions. Use of the invention may provide metrics for the identification of system failure states such as loss of camera vacuum seal, drift in the temperature stabilization, and light leaks. In system aspects of the invention, a processor receives signals from a light detector in the spectrometer and executes software programs to calculate spectral responses, sum or average results, and perform other operations necessary to carry out the disclosed methods. In most preferred embodiments, the light signals received from a sample are used for Raman analysis.

    COST-EFFECTIVE RAMAN PROBE ASSEMBLY FOR SINGLE-USE BIOREACTOR VESSELS
    12.
    发明申请
    COST-EFFECTIVE RAMAN PROBE ASSEMBLY FOR SINGLE-USE BIOREACTOR VESSELS 审中-公开

    公开(公告)号：US20180188180A1

    公开(公告)日：2018-07-05

    申请号：US15398096

    申请日：2017-01-04

    Applicant: Kaiser Optical Systems Inc.

    Inventor： James M. Tedesco ,  Joseph B. Slater

    IPC: G01N21/65 ,  G01N21/03

    CPC classification number: G01N21/65 ,  C12M23/14 ,  C12M41/00 ,  G01J3/0208 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/0303 ,  G01N21/8507 ,  G01N2021/0321 ,  G01N2021/651

    Abstract: Systems and methods are used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. The fixture includes a window to simulate the window in a barb component, a target with a known spectral signature, and a probe head coupled to a spectral analyzer. The axial position of the lens is adjusted with respect to the spacer component to maximize the spectral signature from a sample target, whereupon the spacer component is bonded to the lens mount.

    SYSTEM AND METHOD FOR IMPROVING CALIBRATION TRANSFER BETWEEN MULTIPLE RAMAN ANALYZER INSTALLATIONS
    13.
    发明申请
    SYSTEM AND METHOD FOR IMPROVING CALIBRATION TRANSFER BETWEEN MULTIPLE RAMAN ANALYZER INSTALLATIONS 有权

    公开(公告)号：US20220018780A1

    公开(公告)日：2022-01-20

    申请号：US16932601

    申请日：2020-07-17

    Applicant: Kaiser Optical Systems Inc.

    Inventor： Timothy Norwood ,  Joseph B. Slater ,  James M. Tedesco

    IPC: G01N21/65 ,  G01N21/64

    Abstract: A method for harmonizing the responses of a plurality of Raman analyzers includes steps of calibrating an intensity axis response of a spectrometer to a reference light source and measuring a laser wavelength of a laser using the spectrometer. The method also includes steps of measuring a fluorescence spectrum induced by the laser at the laser wavelength of a plurality of standard reference material samples using the spectrometer, measuring a temperature of each standard reference material sample while measuring the fluorescence spectrum, and correcting the fluorescence spectrum of each standard reference material sample based on the respective temperature. The method further includes steps of deploying each standard reference material sample in one of a plurality of field calibrator devices and calibrating the intensity axis of one of the Raman analyzers using one of the field calibrator devices and the corrected fluorescence spectrum of the respective standard reference material sample.

    Radiation shield for near-infrared detectors
    14.
    发明授权
    Radiation shield for near-infrared detectors 有权

    公开(公告)号：US10753805B2

    公开(公告)日：2020-08-25

    申请号：US15479681

    申请日：2017-04-05

    Applicant: Kaiser Optical Systems Inc.

    Inventor： Joseph B. Slater ,  James M. Tedesco ,  Alfred Feitisch

    IPC: G01J5/06 ,  G01N21/65 ,  G01J3/44 ,  G01J5/04

    Abstract: A radiation shield for near-infrared detectors of the type used in Raman spectroscopic systems comprises a chamber enclosing the detector and a cooling device in thermal contact with the chamber and the detector to reduce the level of unwanted radiation to which the detector would otherwise be exposed. The chamber may include a window in optical alignment with the detector, and the window may include one or more coatings to pass wavelengths in a range of interest or block radiation at wavelengths outside of this range. The shield may be enclosed in an evacuated dewar having a window which may also include one or more coatings to favor the wavelength range.

    Endoscopic immersion probe end optics for laser spectroscopy
    15.
    发明授权
    Endoscopic immersion probe end optics for laser spectroscopy 有权

    公开(公告)号：US10481385B2

    公开(公告)日：2019-11-19

    申请号：US15592506

    申请日：2017-05-11

    Applicant: Kaiser Optical Systems Inc.

    Inventor： James M. Tedesco

    IPC: G02B23/24 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65 ,  G01N21/85 ,  G01J3/02 ,  A61B1/00

    Abstract: In one aspect of the present disclosure, improved end optics are disclosed that maximize the numerical aperture focused at a sample point while minimizing unwanted artifacts such as vignetting. The configurations also maintain centering of the excitation/collection beam on the objective if the probe tilts or bends. The disclosed configurations are particularly suited to probes wherein the excitation and/or collection paths between the probe and the laser/analyzer are coupled through multimode fibers, such as in Raman and other forms of laser spectroscopy. The disclosure includes the insertion of one or more additional lenses between the probe head and the focusing objective at the probe tip.

    METHODS FOR COLLECTION, DARK CORRECTION, AND REPORTING OF SPECTRA FROM ARRAY DETECTOR SPECTROMETER
    16.
    发明申请
    METHODS FOR COLLECTION, DARK CORRECTION, AND REPORTING OF SPECTRA FROM ARRAY DETECTOR SPECTROMETER 审中-公开

    公开(公告)号：US20170241837A1

    公开(公告)日：2017-08-24

    申请号：US15588005

    申请日：2017-05-05

    Applicant: Kaiser Optical Systems, Inc.

    Inventor： Patrick Wiegand ,  James M. Tedesco ,  Joseph B. Slater ,  Francis Esmonde-White

    IPC: G01J3/02 ,  G01J3/44

    CPC classification number: G01J3/0286 ,  G01J3/027 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/2866

    Abstract: Methods and systems for spectrometer dark correction are described which achieve more stable baselines, especially towards the edges where intensity correction magnifies any non-zero results of dark subtraction, and changes in dark current due to changes in temperature of the camera window frame are typically more pronounced. The resulting induced curvature of the baseline makes quantitation difficult in these regions. Use of the invention may provide metrics for the identification of system failure states such as loss of camera vacuum seal, drift in the temperature stabilization, and light leaks. In system aspects of the invention, a processor receives signals from a light detector in the spectrometer and executes software programs to calculate spectral responses, sum or average results, and perform other operations necessary to carry out the disclosed methods. In most preferred embodiments, the light signals received from a sample are used for Raman analysis.

    METHODS FOR COLLECTION, DARK CORRECTION, AND REPORTING OF SPECTRA FROM ARRAY DETECTOR SPECTROMETERS
    18.
    发明申请
    METHODS FOR COLLECTION, DARK CORRECTION, AND REPORTING OF SPECTRA FROM ARRAY DETECTOR SPECTROMETERS 审中-公开
    收集，深度校正和从阵列检测器光谱仪报告光谱的方法

    公开(公告)号：US20160356646A1

    公开(公告)日：2016-12-08

    申请号：US14728818

    申请日：2015-06-02

    Applicant: Kaiser Optical Systems Inc.

    Inventor： Patrick Wiegand ,  James M. Tedesco ,  Joseph B. Slater ,  Francis Esmonde-White

    IPC: G01J3/02 ,  G01J3/44

    CPC classification number: G01J3/0286 ,  G01J3/027 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/2866

    Abstract: Methods and systems for spectrometer dark correction are described which achieve more stable baselines, especially towards the edges where intensity correction magnifies any non-zero results of dark subtraction, and changes in dark current due to changes in temperature of the camera window frame are typically more pronounced. The resulting induced curvature of the baseline makes quantitation difficult in these regions. Use of the invention may provide metrics for the identification of system failure states such as loss of camera vacuum seal, drift in the temperature stabilization, and light leaks. In system aspects of the invention, a processor receives signals from a light detector in the spectrometer and executes software programs to calculate spectral responses, sum or average results, and perform other operations necessary to carry out the disclosed methods. In most preferred embodiments, the light signals received from a sample are used for Raman analysis.

    Abstract translation: 描述了用于光谱仪暗校正的方法和系统，其实现更稳定的基线，特别是对于强度校正放大任何非零零暗结果的边缘的边缘，以及由于相机窗框的温度变化引起的暗电流变化通常更多 发音。 由此导致的基线曲率使得这些区域难以定量化。 使用本发明可以提供用于识别系统故障状态的度量，例如相机真空密封的损失，温度稳定的漂移和光泄漏。 在本发明的系统方面，处理器从光谱仪中的光检测器接收信号，并执行软件程序以计算光谱响应，总和或平均结果，并执行执行所公开方法所需的其它操作。 在最优选的实施例中，从样品接收的光信号用于拉曼分析。

    Spatially offset Raman probe with coaxial excitation and collection apertures
    19.
    发明授权
    Spatially offset Raman probe with coaxial excitation and collection apertures 有权

    公开(公告)号：US11913834B2

    公开(公告)日：2024-02-27

    申请号：US17402798

    申请日：2021-08-16

    Applicant: Kaiser Optical Systems Inc.

    Inventor： James M. Tedesco ,  Sean J. Gilliam

    IPC: G01J3/02 ,  G01J3/12 ,  G01J3/44 ,  G02B6/04

    CPC classification number: G01J3/0243 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/44 ,  G02B6/04 ,  G01J2003/1213

    Abstract: An optical measurement probe for capturing a spectral response through an intervening material emitting unwanted background radiation includes: a first lens configured to receive light and collimate the light into a collimated excitation beam defining a first aperture; an objective element for focusing the collimated excitation beam to a point or region in a sample through the intervening material, wherein the objective element also receives light scattered by the sample and the intervening material and collimates the scattered light into a collimated collection beam defining a second aperture; and a blocking element within the collimated collection beam for removing the light scattered by the intervening material from the collimated collection beam received from the sample, wherein the second aperture defined by the collimated collection beam is at least two times greater than the first aperture defined by the collimated excitation beam.

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